MAP2K5 and CDC42BPB

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		MAP2K5	CDC42BPB
Gene Name		mitogen-activated protein kinase kinase 5	CDC42 binding protein kinase beta (DMPK-like)
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Spindle Cytosol	Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Cell Leading Edge Actomyosin Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity ATP Binding Rho GTPase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Signal Transduction Heart Development Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Phosphorylation Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Migration Actomyosin Structure Organization Actin Cytoskeleton Reorganization Intracellular Signal Transduction Regulation Of Catalytic Activity
Pathways		Signalling to ERK5 Signalling by NGF NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS		Body mass index ( 22344219 20935630) Obesity ( 23563607) Restless legs syndrome ( 17637780 21779176)	Large B-cell lymphoma ( 21471979)
Protein-Protein Interactions		15 interactors: ASRGL1 BAD CDC42BPB ESRRA MAP3K2 MAP3K3 MAPK7 PARD6A PRKCI PRKCZ RPL28 SQSTM1 STAMBP XRCC6 YWHAZ	3 interactors: CDC42 MAP2K5 RIPK1
Entrez ID		5607	9578
HPRD ID		03951	08516
Ensembl ID		ENSG00000137764	ENSG00000198752
Uniprot IDs		A6NK28 Q13163	Q86XZ8 Q9Y5S2
PDB IDs		2NPT 2O2V 4IC7	3QFV 3TKU
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Response To Growth Factor Signal Transduction Cellular Response To Stimulus Phosphorylation Protein Phosphorylation Signaling Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Phosphate-containing Compound Metabolic Process Regulation Of Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Signal Transduction Response To Stimulus Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Membrane Organization Positive Regulation Of Phosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Membrane Potential Positive Regulation Of Kinase Activity Intracellular Transport Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signaling Regulation Of Endothelial Cell Apoptotic Process Response To Transforming Growth Factor Beta Positive Regulation Of Autophagy Positive Regulation Of Glucose Import Cellular Protein Modification Process Regulation Of Cellular Localization Positive Regulation Of Glucose Transport Viral Process Positive Regulation Of Transferase Activity	Positive Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of MAPK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of JNK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Signal Transduction Activation Of MAPK Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of ATP:ADP Antiporter Activity Negative Regulation Of Signaling Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Stress-activated MAPK Cascade Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production ERK5 Cascade Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Necroptotic Process Positive Regulation Of MAP Kinase Activity Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process MAPK Cascade Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway Actin Filament Branching Amyloid Fibril Formation Submandibular Salivary Gland Formation Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation
Tagcloud ?		amico atm dissect entered erg formalin fusions hiseq illumina maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded	associating automated bace1 cation csnk2a1 disturbance disturbances enables gsk3 hallmark hela library linker localization m6pr mannose microtubule notably perturbation precise prkaca prkacg spatially states systematically throughput tracking trafficking visual
Tagcloud (Difference) ?		amico atm dissect entered erg formalin fusions hiseq illumina maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded	associating automated bace1 cation csnk2a1 disturbance disturbances enables gsk3 hallmark hela library linker localization m6pr mannose microtubule notably perturbation precise prkaca prkacg spatially states systematically throughput tracking trafficking visual
Tagcloud (Intersection) ?