MAP2K5 and CDC42BPB

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		MAP2K5	CDC42BPB
Description		mitogen-activated protein kinase kinase 5	CDC42 binding protein kinase beta
Image
GO Annotations	Cellular Component	Spindle	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Membrane Lamellipodium Cell Leading Edge Actomyosin Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Protein-containing Complex Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Signal Transduction Heart Development Positive Regulation Of Cell Growth Negative Regulation Of Interleukin-8 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Phosphorylation Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Migration Actin Cytoskeleton Organization Actomyosin Structure Organization
Pathways		Signalling to ERK5	CDC42 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle
Drugs		Fostamatinib Pimasertib
Diseases
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 20935630 22344219 24861553 28892062 28552196 28448500 25673413 26961502) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Dental caries (decayed and filled deciduous teeth) ( 31533690) Menarche (age at onset) ( 25231870) Motion sickness ( 25628336) Obesity ( 23563607) Proportion of activated microglia (midfrontal cortex) ( 30679421) Restless legs syndrome ( 33239738 17637780 21779176 29029846) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969 32499647) Verbal declarative memory ( 25648963) Waist circumference ( 25673412) Weight ( 28552196)	A body shape index ( 34021172) Body mass index ( 26426971) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		56 interacting genes: AKT1 ARAF ARNT ASRGL1 BAD BECN1 C3orf36 CCND2 CD44 CDC42BPB CDK4 CDK6 CDKN2A CDKN2B CDKN2C DUSP21 EPHA2 ERBB2 ESRRA FGFR4 FZR1 GLIS2 GRM1 GUCD1 HGF HIF1A LATS2 LNX2 MAP2K3 MAP2K6 MAP3K2 MAP3K3 MAPK7 MDM4 MET MYC NF2 PARD6A PDGFRA PFDN5 PRKCI PRKCZ RAF1 RPL28 SQSTM1 STAMBP STK11 TEAD2 TERT TP53 TSC1 UBC XRCC6 YWHAZ ZNF426 ZNF620	7 interacting genes: CDC42 MAP2K5 PPM1A PPP2CA PYGM RIPK1 WDR4
Entrez ID		5607	9578
HPRD ID		03951	08516
Ensembl ID		ENSG00000137764	ENSG00000198752
Uniprot IDs		Q13163	H0YLY0 Q86XZ8 Q9Y5S2
PDB IDs		2NPT 2O2V 4IC7	3QFV 3TKU 4UAK 4UAL 5OTE 5OTF
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Signal Transduction Protein Serine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Cell Population Proliferation MAPK Cascade Animal Organ Development Cellular Response To Stress Cytosol Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Decreased Oxygen Levels Protein Phosphorylation Cell Differentiation ATP Binding Negative Regulation Of Signal Transduction Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen Levels Regulation Of MAPK Cascade Phosphorylation Cellular Developmental Process Regulation Of Cell Cycle Positive Regulation Of Protein Localization Regulation Of Catalytic Activity Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial Cell Proliferation Nucleus Regulation Of Protein Localization To Nucleus Cytoplasm Regulation Of Apoptotic Signaling Pathway Developmental Process Regulation Of Developmental Process Response To Decreased Oxygen Levels Transferase Activity Nucleotide Binding	Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Hippo Signaling Cellular Response To Fluid Shear Stress Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intracellular Signal Transduction Regulation Of Hippo Signaling Tau Protein Binding Response To Fluid Shear Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apical Part Of Cell GBD Domain Binding Storage Vacuole Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine Kinase Activity Cellular Response To Growth Factor Stimulus Protein Dephosphorylation Response To Growth Factor Protein Serine/threonine Phosphatase Activity Regulation Of Canonical NF-kappaB Signal Transduction RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Regulation Of Interleukin-8 Production ERK5 Cascade Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex Protein Serine/threonine Kinase Activity Nucleotide Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Glycogen Phosphorylase Activity Positive Regulation Of Interleukin-6-mediated Signaling Pathway Death Domain Binding TRNA (guanine-N7)-methylation Apolipoprotein A-I Receptor Binding Intracellular Signal Transduction Neuropilin Signaling Pathway Regulation Of Cell Cycle Cytosol N-terminal Protein Myristoylation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Mitotic Cell Cycle Protein Kinase Activity
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