Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
MAP2K5 and MAP3K2
Number of citations of the paper that reports this interaction (PMID
11073940
)
24
Data Source:
BioGRID
(pull down)
HPRD
(two hybrid)
MAP2K5
MAP3K2
Gene Name
mitogen-activated protein kinase kinase 5
mitogen-activated protein kinase kinase kinase 2
Image
Gene Ontology Annotations
Cellular Component
Intracellular
Nucleus
Spindle
Cytosol
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Activation Of MAPK Activity
Signal Transduction
Heart Development
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Growth
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Heterotypic Cell-cell Adhesion
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Interleukin-8 Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Response To Cytokine Stimulus
ERK5 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Activation Of MAPKK Activity
Activation Of MAPK Activity
Protein Phosphorylation
Activation Of JUN Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Cellular Response To Mechanical Stimulus
Pathways
Signalling to ERK5
Signalling by NGF
NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS
Body mass index (
22344219
20935630
)
Obesity (
23563607
)
Restless legs syndrome (
17637780
21779176
)
Protein-Protein Interactions
15 interactors:
ASRGL1
BAD
CDC42BPB
ESRRA
MAP3K2
MAP3K3
MAPK7
PARD6A
PRKCI
PRKCZ
RPL28
SQSTM1
STAMBP
XRCC6
YWHAZ
25 interactors:
BIRC2
IKBKG
MAP2K3
MAP2K4
MAP2K5
MAP2K7
MAP3K3
MAP3K5
MAPK8
NEDD4
NEDD4L
NFKBIA
PIBF1
PKN2
SH2D2A
SMURF1
STAMBP
STUB1
UBC
USP2
WNK1
XIAP
YWHAE
YWHAG
YWHAZ
Entrez ID
5607
10746
HPRD ID
03951
10068
Ensembl ID
ENSG00000137764
ENSG00000169967
Uniprot IDs
A6NK28
Q13163
Q9Y2U5
PDB IDs
2NPT
2O2V
4IC7
2CU1
2NPT
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cell Death
Response To Growth Factor
Signal Transduction
Cellular Response To Stimulus
Phosphorylation
Protein Phosphorylation
Signaling
Neurotrophin TRK Receptor Signaling Pathway
Cell Communication
Neurotrophin Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Apoptotic Process
Phosphate-containing Compound Metabolic Process
Regulation Of Cell Death
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Establishment Of Protein Localization
Regulation Of Intracellular Signal Transduction
Response To Stimulus
Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Cellular Response To Organic Substance
Regulation Of Protein Localization
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Signal Transduction
Membrane Organization
Positive Regulation Of Phosphorylation
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Establishment Or Maintenance Of Cell Polarity
Positive Regulation Of Membrane Potential
Positive Regulation Of Kinase Activity
Intracellular Transport
Cellular Response To Transforming Growth Factor Beta Stimulus
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Signaling
Regulation Of Endothelial Cell Apoptotic Process
Response To Transforming Growth Factor Beta
Positive Regulation Of Autophagy
Positive Regulation Of Glucose Import
Cellular Protein Modification Process
Regulation Of Cellular Localization
Positive Regulation Of Glucose Transport
Viral Process
Positive Regulation Of Transferase Activity
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Protein Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Signal Transduction
Intracellular Signal Transduction
Apoptotic Process
Toll-like Receptor 5 Signaling Pathway
Programmed Cell Death
Toll-like Receptor 10 Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Signaling
Toll-like Receptor Signaling Pathway
Cell Death
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Death
Cell Communication
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
MyD88-dependent Toll-like Receptor Signaling Pathway
MAPK Cascade
Activation Of MAPK Activity
Activation Of Innate Immune Response
Positive Regulation Of Protein Metabolic Process
Regulation Of Innate Immune Response
Cellular Response To Stimulus
Signal Transduction By Phosphorylation
Positive Regulation Of Innate Immune Response
Response To Stimulus
Regulation Of Apoptotic Process
Cellular Protein Modification Process
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Regulation Of Cell Death
Positive Regulation Of MAP Kinase Activity
Activation Of Protein Kinase Activity
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
JNK Cascade
Regulation Of MAP Kinase Activity
Positive Regulation Of Protein Modification Process
Cellular Response To Stress
Regulation Of Catalytic Activity
Tagcloud
?
amico
atm
dissect
entered
erg
formalin
fusions
hiseq
illumina
maximise
mek5
men1
nbpf10
ncor2
needle
ngs
opening
pik3cb
qiagen
read
routinely
screen
sections
spop
technologies
templates
tmprrs2
unstained
yielded
Tagcloud (Difference)
?
amico
atm
dissect
entered
erg
formalin
fusions
hiseq
illumina
maximise
mek5
men1
nbpf10
ncor2
needle
ngs
opening
pik3cb
qiagen
read
routinely
screen
sections
spop
technologies
templates
tmprrs2
unstained
yielded
Tagcloud (Intersection)
?