MAP2K5 and MAP2K3

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MAP2K5	MAP2K3
Description		mitogen-activated protein kinase kinase 5	mitogen-activated protein kinase kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Spindle	Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Signal Transduction Heart Development Positive Regulation Of Cell Growth Negative Regulation Of Interleukin-8 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	MAPK Cascade Regulation Of Cytokine Production Response To Ischemia Inflammatory Response Signal Transduction Heart Development Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Hippo Signaling Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA-templated Transcription Protein Maturation Cardiac Muscle Contraction Pyroptotic Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To UV-B Cellular Response To Sorbitol Cellular Senescence Regulation Of Intracellular Signal Transduction NLRP1 Inflammasome Complex Assembly
Pathways		Signalling to ERK5	Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation
Drugs		Fostamatinib Pimasertib	Fostamatinib Pimasertib
Diseases
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 20935630 22344219 24861553 28892062 28552196 28448500 25673413 26961502) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Dental caries (decayed and filled deciduous teeth) ( 31533690) Menarche (age at onset) ( 25231870) Motion sickness ( 25628336) Obesity ( 23563607) Proportion of activated microglia (midfrontal cortex) ( 30679421) Restless legs syndrome ( 33239738 17637780 21779176 29029846) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969 32499647) Verbal declarative memory ( 25648963) Waist circumference ( 25673412) Weight ( 28552196)	Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062)
Interacting Genes		56 interacting genes: AKT1 ARAF ARNT ASRGL1 BAD BECN1 C3orf36 CCND2 CD44 CDC42BPB CDK4 CDK6 CDKN2A CDKN2B CDKN2C DUSP21 EPHA2 ERBB2 ESRRA FGFR4 FZR1 GLIS2 GRM1 GUCD1 HGF HIF1A LATS2 LNX2 MAP2K3 MAP2K6 MAP3K2 MAP3K3 MAPK7 MDM4 MET MYC NF2 PARD6A PDGFRA PFDN5 PRKCI PRKCZ RAF1 RPL28 SQSTM1 STAMBP STK11 TEAD2 TERT TP53 TSC1 UBC XRCC6 YWHAZ ZNF426 ZNF620	53 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53
Entrez ID		5607	5606
HPRD ID		03951	03816
Ensembl ID		ENSG00000137764	ENSG00000034152
Uniprot IDs		Q13163	P46734 Q6FI23
PDB IDs		2NPT 2O2V 4IC7
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Signal Transduction Protein Serine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Cell Population Proliferation MAPK Cascade Animal Organ Development Cellular Response To Stress Cytosol Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Decreased Oxygen Levels Protein Phosphorylation Cell Differentiation ATP Binding Negative Regulation Of Signal Transduction Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen Levels Regulation Of MAPK Cascade Phosphorylation Cellular Developmental Process Regulation Of Cell Cycle Positive Regulation Of Protein Localization Regulation Of Catalytic Activity Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial Cell Proliferation Nucleus Regulation Of Protein Localization To Nucleus Cytoplasm Regulation Of Apoptotic Signaling Pathway Developmental Process Regulation Of Developmental Process Response To Decreased Oxygen Levels Transferase Activity Nucleotide Binding	Protein Serine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Kinase Activity Regulation Of Cell Cycle MAP Kinase Kinase Kinase Activity Regulation Of Intracellular Signal Transduction Animal Organ Development Developmental Process Regulation Of Cell Population Proliferation Regulation Of Cellular Component Organization Signal Transduction Regulation Of Cell Cycle Process Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Signaling Regulation Of Cell Communication Transferase Activity Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Cellular Developmental Process Response To Growth Factor Cell Differentiation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition ATP Binding Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Component Organization Cytosol Positive Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Metabolic Process Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Differentiation Regulation Of Growth Regulation Of Apoptotic Process
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