MAP2K5 and ASRGL1

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		MAP2K5	ASRGL1
Name		mitogen-activated protein kinase kinase 5	asparaginase and isoaspartyl peptidase 1
Structure
GO Annotations	Cellular Component	Spindle	Photoreceptor Inner Segment Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	N4-(beta-N-acetylglucosaminyl)-L-asparaginase Activity Asparaginase Activity Peptidase Activity Beta-aspartyl-peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Signal Transduction Heart Development Positive Regulation Of Cell Growth Negative Regulation Of Interleukin-8 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Proteolysis L-asparagine Catabolic Process Via L-aspartate
Pathways		Signalling to ERK5	Phenylalanine metabolism
Drugs		Fostamatinib Pimasertib	Aspartic acid Asparagine
GWAS		Adult body size ( 32376654 ) Asthma ( 31959851 ) Bipolar disorder or body mass index ( 31754094 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) Body mass index ( 20935630 22344219 24861553 28892062 28552196 28448500 25673413 26961502 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Body size at age 10 ( 32376654 ) Dental caries (decayed and filled deciduous teeth) ( 31533690 ) Menarche (age at onset) ( 25231870 ) Motion sickness ( 25628336 ) Obesity ( 23563607 ) Proportion of activated microglia (midfrontal cortex) ( 30679421 ) Restless legs syndrome ( 33239738 17637780 21779176 29029846 ) Smoking status (ever vs never smokers) ( 30643258 ) Triglyceride levels ( 32154731 ) Type 2 diabetes ( 30297969 32499647 ) Verbal declarative memory ( 25648963 ) Waist circumference ( 25673412 ) Weight ( 28552196 )	Body fat mass ( 28552196 ) Chronic obstructive pulmonary disease-related biomarkers ( 23144326 ) Heel bone mineral density ( 30598549 ) Serum metabolite levels ( 33031748 ) Trunk fat mass ( 28552196 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		56 interacting genes: AKT1 ARAF ARNT ASRGL1 BAD BECN1 C3orf36 CCND2 CD44 CDC42BPB CDK4 CDK6 CDKN2A CDKN2B CDKN2C DUSP21 EPHA2 ERBB2 ESRRA FGFR4 FZR1 GLIS2 GRM1 GUCD1 HGF HIF1A LATS2 LNX2 MAP2K3 MAP2K6 MAP3K2 MAP3K3 MAPK7 MDM4 MET MYC NF2 PARD6A PDGFRA PFDN5 PRKCI PRKCZ RAF1 RPL28 SQSTM1 STAMBP STK11 TEAD2 TERT TP53 TSC1 UBC XRCC6 YWHAZ ZNF426 ZNF620	5 interacting genes: ERBB2 GSK3B MAP2K5 MAPK8IP2 TAB1
Entrez ID		5607	80150
HPRD ID		03951	07006
Ensembl ID		ENSG00000137764	ENSG00000162174
Uniprot IDs		Q13163	A0A024R573 Q7L266
PDB IDs		2NPT 2O2V 4IC7	3TKJ 4ET0 4O0C 4O0D 4O0E 4O0F 4O0G 4O0H 4OSX 4OSY 4PVP 4PVQ 4PVR 4PVS 4ZM9
GO Terms Enriched among Interactors		Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Signal Transduction Protein Serine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Cell Population Proliferation MAPK Cascade Animal Organ Development Cellular Response To Stress Cytosol Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Decreased Oxygen Levels Protein Phosphorylation Cell Differentiation ATP Binding Negative Regulation Of Signal Transduction Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen Levels Regulation Of MAPK Cascade Phosphorylation Cellular Developmental Process Regulation Of Cell Cycle Positive Regulation Of Protein Localization Regulation Of Catalytic Activity Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial Cell Proliferation Nucleus Regulation Of Protein Localization To Nucleus Cytoplasm Regulation Of Apoptotic Signaling Pathway Developmental Process Regulation Of Developmental Process Response To Decreased Oxygen Levels Transferase Activity Nucleotide Binding	Intracellular Signaling Cassette Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Growth Regulation Of Apoptotic Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Positive Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Protein Kinase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication ERBB3:ERBB2 Complex Regulation Of Growth Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Signaling Protein Tyrosine Kinase Activity Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity ERK5 Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of Translation RNA Polymerase I Core Binding Positive Regulation Of Cell Growth Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Adhesion Signal Transduction Positive Regulation Of Protein Metabolic Process Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Immature T Cell Proliferation In Thymus ErbB-3 Class Receptor Binding Positive Regulation Of Epithelial Cell Proliferation