MAP2K5 and ASRGL1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MAP2K5	ASRGL1
Gene Name		mitogen-activated protein kinase kinase 5	asparaginase like 1
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Spindle Cytosol	Nucleus Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	N4-(beta-N-acetylglucosaminyl)-L-asparaginase Activity Asparaginase Activity Beta-aspartyl-peptidase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Signal Transduction Heart Development Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Proteolysis Asparagine Catabolic Process Via L-aspartate
Pathways		Signalling to ERK5 Signalling by NGF NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS		Body mass index ( 22344219 20935630) Obesity ( 23563607) Restless legs syndrome ( 17637780 21779176)	Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Protein-Protein Interactions		15 interactors: ASRGL1 BAD CDC42BPB ESRRA MAP3K2 MAP3K3 MAPK7 PARD6A PRKCI PRKCZ RPL28 SQSTM1 STAMBP XRCC6 YWHAZ	4 interactors: GSK3B MAP2K5 MAPK8IP2 TAB1
Entrez ID		5607	80150
HPRD ID		03951	07006
Ensembl ID		ENSG00000137764	ENSG00000162174
Uniprot IDs		A6NK28 Q13163	Q7L266
PDB IDs		2NPT 2O2V 4IC7	3TKJ 4ET0 4GDT 4GDU 4GDV 4GDW 4HLO 4HLP
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Response To Growth Factor Signal Transduction Cellular Response To Stimulus Phosphorylation Protein Phosphorylation Signaling Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Phosphate-containing Compound Metabolic Process Regulation Of Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Signal Transduction Response To Stimulus Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Membrane Organization Positive Regulation Of Phosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Membrane Potential Positive Regulation Of Kinase Activity Intracellular Transport Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signaling Regulation Of Endothelial Cell Apoptotic Process Response To Transforming Growth Factor Beta Positive Regulation Of Autophagy Positive Regulation Of Glucose Import Cellular Protein Modification Process Regulation Of Cellular Localization Positive Regulation Of Glucose Transport Viral Process Positive Regulation Of Transferase Activity	Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process MAPK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction By Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Phosphorylation Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Protein Metabolic Process JNK Cascade Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Stress-activated MAPK Cascade Positive Regulation Of Cell Growth Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Activation Of MAPK Activity Enzyme Linked Receptor Protein Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Signaling Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production ERK5 Cascade Superior Temporal Gyrus Development Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of MAP Kinase Activity Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		amico atm dissect entered erg formalin fusions hiseq illumina maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Difference) ?		amico atm dissect entered erg formalin fusions hiseq illumina maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Intersection) ?