MAP2K5 and RPL28

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		MAP2K5	RPL28
Name		mitogen-activated protein kinase kinase 5	ribosomal protein L28
Structure
GO Annotations	Cellular Component	Spindle	Cytoplasm Cytosol Ribosome Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Dendrite Cytoplasmic Ribonucleoprotein Granule Cell Body Synapse Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Signal Transduction Heart Development Positive Regulation Of Cell Growth Negative Regulation Of Interleukin-8 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Cytoplasmic Translation Translation
Pathways		Signalling to ERK5	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		Fostamatinib Pimasertib	None
GWAS		Adult body size ( 32376654 ) Asthma ( 31959851 ) Bipolar disorder or body mass index ( 31754094 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) Body mass index ( 20935630 22344219 24861553 28892062 28552196 28448500 25673413 26961502 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Body size at age 10 ( 32376654 ) Dental caries (decayed and filled deciduous teeth) ( 31533690 ) Menarche (age at onset) ( 25231870 ) Motion sickness ( 25628336 ) Obesity ( 23563607 ) Proportion of activated microglia (midfrontal cortex) ( 30679421 ) Restless legs syndrome ( 33239738 17637780 21779176 29029846 ) Smoking status (ever vs never smokers) ( 30643258 ) Triglyceride levels ( 32154731 ) Type 2 diabetes ( 30297969 32499647 ) Verbal declarative memory ( 25648963 ) Waist circumference ( 25673412 ) Weight ( 28552196 )	Retinitis pigmentosa ( 33514863 )
Interacting Genes		56 interacting genes: AKT1 ARAF ARNT ASRGL1 BAD BECN1 C3orf36 CCND2 CD44 CDC42BPB CDK4 CDK6 CDKN2A CDKN2B CDKN2C DUSP21 EPHA2 ERBB2 ESRRA FGFR4 FZR1 GLIS2 GRM1 GUCD1 HGF HIF1A LATS2 LNX2 MAP2K3 MAP2K6 MAP3K2 MAP3K3 MAPK7 MDM4 MET MYC NF2 PARD6A PDGFRA PFDN5 PRKCI PRKCZ RAF1 RPL28 SQSTM1 STAMBP STK11 TEAD2 TERT TP53 TSC1 UBC XRCC6 YWHAZ ZNF426 ZNF620	9 interacting genes: CCNDBP1 FNDC3B FOXP1 MAP2K5 PTEN SGO1 SMAD4 STAU1 TMEM230
Entrez ID		5607	6158
HPRD ID		03951	04702
Ensembl ID		ENSG00000137764	ENSG00000108107
Uniprot IDs		Q13163	H0YKD8 P46779
PDB IDs		2NPT 2O2V 4IC7	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKQ 8FKS 8FKU 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FPZ 9FQ0 9G8M 9GMO
GO Terms Enriched among Interactors		Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Signal Transduction Protein Serine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Cell Population Proliferation MAPK Cascade Animal Organ Development Cellular Response To Stress Cytosol Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Decreased Oxygen Levels Protein Phosphorylation Cell Differentiation ATP Binding Negative Regulation Of Signal Transduction Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen Levels Regulation Of MAPK Cascade Phosphorylation Cellular Developmental Process Regulation Of Cell Cycle Positive Regulation Of Protein Localization Regulation Of Catalytic Activity Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial Cell Proliferation Nucleus Regulation Of Protein Localization To Nucleus Cytoplasm Regulation Of Apoptotic Signaling Pathway Developmental Process Regulation Of Developmental Process Response To Decreased Oxygen Levels Transferase Activity Nucleotide Binding	Endothelial Cell Activation Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Growth Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Growth Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Organ Growth Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Intracellular Signal Transduction Gonad Morphogenesis Negative Regulation Of Cardiac Myofibril Assembly Nephrogenic Mesenchyme Morphogenesis Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Growth Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis ERK5 Cascade Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Regulation Of Organ Growth Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Axo-dendritic Transport Positive Regulation Of Interleukin-21 Production Negative Regulation Of Developmental Growth Regulation Of Chemokine Production Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Metanephric Mesenchyme Morphogenesis Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Mitotic Sister Chromatid Cohesion, Centromeric Osteoblast Differentiation Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation By Virus Of Viral Protein Levels In Host Cell Regulation Of System Process Sulfate Binding Endocardial Cell Differentiation Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Regulation Of Smooth Muscle Cell Proliferation