MAP2K5 and RPL28

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MAP2K5	RPL28
Gene Name		mitogen-activated protein kinase kinase 5	ribosomal protein L28
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Spindle Cytosol	Cytoplasm Cytosol Membrane Cytosolic Large Ribosomal Subunit Dendrite Cytoplasmic Ribonucleoprotein Granule Cell Body Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Signal Transduction Heart Development Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways		Signalling to ERK5 Signalling by NGF NGF signalling via TRKA from the plasma membrane	Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Body mass index ( 22344219 20935630) Obesity ( 23563607) Restless legs syndrome ( 17637780 21779176)
Protein-Protein Interactions		15 interactors: ASRGL1 BAD CDC42BPB ESRRA MAP3K2 MAP3K3 MAPK7 PARD6A PRKCI PRKCZ RPL28 SQSTM1 STAMBP XRCC6 YWHAZ	6 interactors: CCNDBP1 MAP2K5 SGOL1 SMAD4 STAU1 TMEM230
Entrez ID		5607	6158
HPRD ID		03951	04702
Ensembl ID		ENSG00000137764	ENSG00000108107
Uniprot IDs		A6NK28 Q13163	H0YKD8 P46779
PDB IDs		2NPT 2O2V 4IC7	3J3B
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Response To Growth Factor Signal Transduction Cellular Response To Stimulus Phosphorylation Protein Phosphorylation Signaling Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Phosphate-containing Compound Metabolic Process Regulation Of Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Signal Transduction Response To Stimulus Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Membrane Organization Positive Regulation Of Phosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Membrane Potential Positive Regulation Of Kinase Activity Intracellular Transport Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signaling Regulation Of Endothelial Cell Apoptotic Process Response To Transforming Growth Factor Beta Positive Regulation Of Autophagy Positive Regulation Of Glucose Import Cellular Protein Modification Process Regulation Of Cellular Localization Positive Regulation Of Glucose Transport Viral Process Positive Regulation Of Transferase Activity	Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production ERK5 Cascade Nephrogenic Mesenchyme Morphogenesis Positive Regulation By Virus Of Viral Protein Levels In Host Cell Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Negative Regulation Of Interleukin-8 Biosynthetic Process Endocardial Cell Differentiation Centriole-centriole Cohesion Negative Regulation Of Heterotypic Cell-cell Adhesion Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Formation Of Anatomical Boundary Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Endothelial Cell Activation Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Cell Growth Positive Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Valve Formation Sebaceous Gland Development Intracellular MRNA Localization Regulation Of Interleukin-8 Biosynthetic Process Attachment Of Spindle Microtubules To Kinetochore Somite Rostral/caudal Axis Specification Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Brainstem Development SMAD Protein Complex Assembly Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Canal Development Negative Regulation Of Interleukin-8 Production Regulation Of Hair Follicle Development Heart Valve Formation Metanephric Mesenchyme Development Endocardial Cushion Formation Endocardium Development Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cellular Response To Fluid Shear Stress Atrioventricular Valve Morphogenesis Response To Laminar Fluid Shear Stress Regulation Of Sprouting Angiogenesis Regulation Of Hair Cycle Negative Regulation Of Blood Vessel Endothelial Cell Migration Endocardial Cushion Morphogenesis Atrioventricular Valve Development Heart Development Positive Regulation Of Viral Genome Replication Cardiac Epithelial To Mesenchymal Transition Regulation Of Cytokine Production Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		amico atm dissect entered erg formalin fusions hiseq illumina maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Difference) ?		amico atm dissect entered erg formalin fusions hiseq illumina maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Intersection) ?