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MAPK8 and SMAD2
Number of citations of the paper that reports this interaction (PubMedID
15326485
)
0
Data Source:
HPRD
(in vitro, in vivo)
MAPK8
SMAD2
Description
mitogen-activated protein kinase 8
SMAD family member 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Axon
Synapse
Basal Dendrite
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Activin Responsive Factor Complex
Protein-containing Complex
SMAD Protein Complex
Homomeric SMAD Protein Complex
Heteromeric SMAD Protein Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Phosphatase Binding
Histone Deacetylase Regulator Activity
Histone Deacetylase Binding
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Phosphatase Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Identical Protein Binding
SMAD Binding
Metal Ion Binding
Tau Protein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Co-SMAD Binding
I-SMAD Binding
R-SMAD Binding
Disordered Domain Specific Binding
DNA-binding Transcription Factor Binding
Biological Process
MAPK Cascade
Double-strand Break Repair
Protein Phosphorylation
Response To Oxidative Stress
JNK Cascade
JUN Phosphorylation
Response To UV
Response To Mechanical Stimulus
Positive Regulation Of Gene Expression
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Positive Regulation Of Cyclase Activity
Positive Regulation Of Cell Killing
Negative Regulation Of Protein Binding
Regulation Of Protein Localization
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Fc-epsilon Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of MRNA Stability
NLRP3 Inflammasome Complex Assembly
Rhythmic Process
Positive Regulation Of Protein Metabolic Process
Stress-activated MAPK Cascade
MRNA Destabilization
Protein Poly-ADP-ribosylation
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Senescence
Energy Homeostasis
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Establishment Of Protein Localization To Mitochondrion
Protein Localization To Site Of Double-strand Break
Ureteric Bud Development
In Utero Embryonic Development
Endoderm Formation
Mesoderm Formation
Regionalization
Determination Of Left/right Asymmetry In Lateral Mesoderm
Aortic Valve Morphogenesis
Pulmonary Valve Morphogenesis
Endocardial Cushion Morphogenesis
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Transforming Growth Factor Beta Receptor Signaling Pathway
Zygotic Specification Of Dorsal/ventral Axis
Gastrulation
Pattern Specification Process
Endoderm Development
Mesoderm Development
Heart Development
Cell Population Proliferation
Anatomical Structure Morphogenesis
Response To Glucose
Post-embryonic Development
Embryonic Pattern Specification
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Insulin Secretion
Cell Differentiation
Negative Regulation Of Ossification
Lung Development
Positive Regulation Of BMP Signaling Pathway
Pancreas Development
Primary MiRNA Processing
Activin Receptor Signaling Pathway
Organ Growth
Intracellular Signal Transduction
Nodal Signaling Pathway
Cell Fate Commitment
Negative Regulation Of Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Morphogenesis
Developmental Growth
Embryonic Foregut Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Regulation Of Multicellular Organismal Process
Pericardium Development
SMAD Protein Signal Transduction
Mesenchyme Development
Trophoblast Cell Migration
Secondary Palate Development
Response To Cholesterol
Response To Transforming Growth Factor Beta
Odontoblast Differentiation
Pathways
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
NRAGE signals death through JNK
NRAGE signals death through JNK
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Interleukin-38 signaling
WNT5:FZD7-mediated leishmania damping
Signaling by ALK fusions and activated point mutants
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Germ layer formation at gastrulation
Formation of axial mesoderm
Formation of definitive endoderm
Formation of definitive endoderm
Drugs
Tamoxifen
Minocycline
Pyrazolanthrone
6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE
2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE
N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE
5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE
2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
Halicin
Dexfosfoserine
Diseases
Colorectal cancer
GWAS
Blood protein levels in cardiovascular risk (
28369058
)
Daytime sleep phenotypes (
27126917
)
Opioid dependence (time to event) (
34124712
)
Refractive error (
32231278
)
Coronary artery disease in type 1 diabetes (
29695241
)
Daytime nap (
33568662
)
Lung cancer in ever smokers (
28604730
)
Menarche (age at onset) (
27182965
)
Interacting Genes
140 interacting genes:
AIMP1
AKT1
APBB2
APLP2
APP
ATF2
ATM
BAD
BCL2
BCL2L1
BCL2L11
BMF
BMPR2
CAMP
CASP3
CBL
CCDC88C
CDKN1A
CDKN2A
CDKN2C
CEBPA
COPS2
CRK
CTNNB1
DUSP1
DUSP10
DUSP16
DUSP22
DUSP4
DUSP7
EEF2K
EGFR
ELK1
ELK3
ELK4
ELP1
EP300
ETV1
FAM193B
FZR1
GANAB
GARS1
GEMIN5
GFPT1
GORASP2
GSTP1
GUCY1A1
H2AX
HDAC9
HIVEP1
HRAS
HSD17B4
HSF1
HSF4
HSPA8
ID2
IL27RA
IRAK1
IRF3
IRS1
ITCH
JDP2
JKAMP
JUN
JUNB
JUND
KRT8
MAP1B
MAP2K1
MAP2K2
MAP2K4
MAP2K7
MAP3K2
MAP3K7
MAPK1
MAPK14
MAPK3
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAP1
MAPKBP1
MAPT
MBP
METTL3
MKNK2
MYC
NCOA3
NFATC3
NFATC4
NFE2
NFE2L2
NKAPD1
NR3C1
NR4A1
PAX2
PDPK1
PIAS2
PIK3R1
PKMYT1
PNRC1
PPARG
PRKD1
PRKDC
PXN
RAD18
RAF1
RASSF1
RBM15
REL
RET
RPLP2
RPS6KB1
SCAND1
SCOC
SERPINB3
SH3BP5
SHC1
SIRT1
SMAD2
SMAD3
SNCA
SNCG
SP1
SPAG9
SPI1
SPIB
SSU72
STAT3
TFCP2
TNFSF11
TP53
TP73
TRAF6
WDR62
WWOX
XRCC6
YWHAZ
ZNF219
ZNF605
220 interacting genes:
ABTB1
ACVR1B
AFDN
AKT1
ANAPC10
ANAPC2
ANK3
ANP32B
ANP32E
ANTXR2
AP1B1
ARFGAP3
ARHGEF6
ARL4D
ATP5ME
AXIN1
BAZ1A
BECN1
BPTF
BRCA1
BTBD2
C22orf46P
CAMK2A
CAMK2G
CDC16
CDC27
CDC40
CDK2
CDK4
CDK8
CDK9
CISH
COPS5
CORO2A
CREBBP
CSH1
CSH2
CSNK1D
CTNNB1
CUL5
CYLC2
CYP11A1
DAB2
DCAF6
DCUN1D1
DENND2B
DNAJB5
DNAJC7
DOCK8
DVL1
DYNC1H1
DYRK1A
E2F4
EEF1A1
EID2
EIF3L
ELAC2
EP300
ERBIN
ESR1
ESR2
FAM161B
FBN2
FBP2
FHL2
FHL3
FOXG1
FOXH1
FOXO3
GATAD2B
GFER
GLI3
GRIPAP1
GSC
GTF2I
HDAC1
HDAC2
HGS
HIPK2
HNF4A
HOXA13
HOXA9
HOXD13
HSD17B3
HUWE1
HYAL2
INSR
IRAK2
ITCH
JUN
KAT2B
KHDRBS1
KPNB1
LAMA5
LATS2
LCK
LEF1
LEMD3
LHX9
LITAF
LMO2
MAP2K1
MAPK1
MAPK3
MAPK8
MAPK9
MECOM
MED15
MED6
MEF2A
MEF2C
MYC
MYOCD
NAGK
NCOA6
NEDD4L
NEDD9
NEFM
NFIA
NFYC
NOTCH4
NUAK2
NUP153
NUP214
OS9
OTUB1
PAK1
PAPOLA
PAPPA
PARD3
PAXIP1
PEX19
PIAS3
PIAS4
PIK3CA
PLIN3
POU2AF1
PPM1A
PPP2R1A
PRKAR1A
PSAP
PSG9
PSMD11
PSMD8
PTMS
RAB34
RAB38
RAN
RANBP6
RANBP9
RARB
RASA1
RASD2
RASL12
RBL1
RHEBL1
RHOA
RHOD
RHOJ
RIT1
RNF123
RNPC3
ROCK1
RPS14
RPS27A
RUNX2
RXRA
SKI
SKIL
SKOR2
SMAD1
SMAD3
SMAD4
SMAD7
SMAD9
SMURF1
SMURF2
SNAPIN
SNIP1
SNRNP70
SNW1
SOD1
SP1
SQSTM1
SRI
ST13
STAG1
STAMBP
STAMBPL1
STRAP
STUB1
SYT1
TBC1D1
TGFBR1
TGFBRAP1
TGIF1
TGM2
TNNT1
TOB1
TP53
TP73
TRIM62
TRMO
TSC2
TUBA1B
UBA52
UBR5
UCHL5
USP9X
WASHC4
XPA
YY1
ZEB1
ZEB2
ZFYVE9
ZMYND11
ZNF41
ZNF510
ZNF8
ZNHIT6
Entrez ID
5599
4087
HPRD ID
03100
03221
Ensembl ID
ENSG00000107643
ENSG00000175387
Uniprot IDs
A1L4K2
P45983
B7Z5N5
Q15796
Q53XR6
PDB IDs
1UKH
1UKI
2G01
2GMX
2H96
2NO3
2XRW
2XS0
3ELJ
3O17
3O2M
3PZE
3V3V
3VUD
3VUG
3VUH
3VUI
3VUK
3VUL
3VUM
4AWI
4E73
4G1W
4HYS
4HYU
4IZY
4L7F
4QTD
4UX9
4YR8
5LW1
6F5E
6ZR5
8PT8
8PT9
8PTA
8R5E
8X5M
9FT9
1DEV
1KHX
1U7V
2LB3
5XOD
5ZOJ
6H3R
6M64
6YIA
6ZVQ
7CO1
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Intracellular Signaling Cassette
Regulation Of Intracellular Signal Transduction
Signal Transduction
MAPK Cascade
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Response To Stress
Regulation Of Primary Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Cellular Response To Stress
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Regulation Of Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
Cellular Developmental Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Response To Growth Factor
Regulation Of Signaling
Cellular Response To Oxygen-containing Compound
Regulation Of Cell Communication
Regulation Of DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Regulation Of MAPK Cascade
Regulation Of Transcription By RNA Polymerase II
Response To Lipid
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Nucleus
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Multicellular Organismal Process
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Signal Transduction
Response To Hormone
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Cell Surface Receptor Signaling Pathway
Programmed Cell Death
Cell Death
Regulation Of Cell Differentiation
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Nucleoplasm
SMAD Binding
Regulation Of Signal Transduction
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Transcription Regulator Complex
Regulation Of Primary Metabolic Process
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Nucleus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell Communication
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Signaling
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Developmental Process
Positive Regulation Of Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Intracellular Signal Transduction
Chromatin
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Enzyme-linked Receptor Protein Signaling Pathway
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
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