MAPK8 and BAD

Number of citations of the paper that reports this interaction (PMID 14967141)
48

Data Source:
HPRD (in vitro)

		MAPK8	BAD
Gene Name		mitogen-activated protein kinase 8	BCL2-associated agonist of cell death
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol	Mitochondrion Mitochondrial Outer Membrane Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity JUN Kinase Activity Protein Binding ATP Binding Enzyme Binding Histone Deacetylase Regulator Activity Histone Deacetylase Binding	Protein Binding Phospholipid Binding Lipid Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Kinase Binding Protein Phosphatase 2B Binding Protein Kinase B Binding Protein Heterodimerization Activity
	Biological Process	Ossification Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Apoptotic Process Response To Stress JNK Cascade JUN Phosphorylation Response To UV Positive Regulation Of Gene Expression Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Histone Deacetylation Negative Regulation Of Protein Binding Regulation Of Protein Localization Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Response To Cadmium Ion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Deacetylase Activity Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity	Release Of Cytochrome C From Mitochondria Glucose Catabolic Process Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Glucose Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Potential Suppression By Virus Of Host Apoptotic Process Cytokine-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Response To Estradiol Response To Progesterone Positive Regulation Of Glucokinase Activity Response To Testosterone Response To Oleic Acid Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Fc-epsilon Receptor Signaling Pathway Response To Drug Response To Hydrogen Peroxide Glucose Homeostasis Positive Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Type B Pancreatic Cell Proliferation Innate Immune Response Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Proteolysis ADP Metabolic Process ATP Metabolic Process Regulation Of Mitochondrial Membrane Permeability Pore Complex Assembly Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Epithelial Cell Proliferation Response To Glucocorticoid Response To Calcium Ion Positive Regulation Of Apoptotic Process By Virus Cellular Process Regulating Host Cell Cycle In Response To Virus Cellular Response To Chromate Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Lipid Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Positive Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence Activation of BH3-only proteins FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activation of BMF and translocation to mitochondria Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Programmed Cell Death MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Intrinsic Pathway for Apoptosis JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade DSCAM interactions NRIF signals cell death from the nucleus Oxidative Stress Induced Senescence Activation of BIM and translocation to mitochondria Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade NRAGE signals death through JNK Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Activation of BH3-only proteins Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Programmed Cell Death Innate Immune System Intrinsic Pathway for Apoptosis Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Cell death signalling via NRAGE, NRIF and NADE Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR NRAGE signals death through JNK Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Mean platelet volume ( 22423221) Sarcoidosis ( 22837380)
Protein-Protein Interactions		134 interactors: AIMP1 APLP2 APP ATF2 BAD BCL2 BCL2L1 BCL2L11 BMF BMPR2 C11orf57 CAMP CASP3 CBL CCDC88C CDKN1A CDKN2A CDKN2C CEBPA COPS2 CRK CTNNB1 DUSP1 DUSP10 DUSP16 DUSP22 DUSP4 DUSP7 DUSP8 EEF2K ELK1 ELK3 ELK4 EP300 ETV1 FAM193B FZR1 GANAB GARS GEMIN5 GFPT1 GORASP2 GSTP1 GUCY1A3 HDAC9 HIVEP1 HRAS HSD17B4 HSF1 HSF4 HSPA8 ID2 IKBKAP IL27RA IRAK1 IRF3 IRS1 ITCH JDP2 JKAMP JUN JUNB JUND KRT8 MAP1B MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K1 MAP3K2 MAP3K4 MAP3K7 MAPK1 MAPK14 MAPK3 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAP1 MAPKBP1 MAPT MKNK2 MYC NCOA3 NFATC3 NFATC4 NFE2 NR3C1 NR4A1 PAX2 PDPK1 PIAS2 PIK3R1 PKMYT1 PNRC1 PPARG PRKD1 PRKDC PXN RAD18 RAF1 RASSF1 RBM15 REL RET RPLP2 RPS6KB1 SCAND1 SCOC SERPINB3 SERPINB4 SH3BP5 SHC1 SIRT1 SMAD2 SMAD3 SNCG SP1 SPAG9 SPI1 SPIB SSU72 STAT3 TFCP2 TNFSF11 TP53 TP73 TRAF6 WDR62 WWOX XRCC6 YWHAZ ZNF219	43 interactors: AKT1 ARAF BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BRAF CDKN1A CREB3L3 EWSR1 HRK KEAP1 MAP2K5 MAPK8 MCL1 PAK1 PAK7 PIM1 PIM2 PIM3 PPP1CA PPP3CA PRDX2 PRKACA PRKCI RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A10 SFN SNCA STEAP3 SUMO2 WASF1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		5599	572
HPRD ID		03100	04409
Ensembl ID		ENSG00000107643	ENSG00000002330
Uniprot IDs		A1L4K2 P45983 Q308M2	Q92934
PDB IDs		1UKH 1UKI 2G01 2GMX 2H96 2NO3 2XRW 2XS0 3ELJ 3O17 3O2M 3PZE 3V3V 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4AWI 4E73 4G1W 4L7F	1G5J
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Phosphorylation Response To Stress Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Response To Organic Substance Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Kinase Activity Response To Growth Factor Apoptotic Process Cellular Response To Stimulus Programmed Cell Death Cellular Response To Stress Signaling Signal Transduction Cell Death Death MAPK Cascade Cell Communication Positive Regulation Of Cellular Biosynthetic Process Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Signal Transduction By Phosphorylation Negative Regulation Of Cellular Metabolic Process Defense Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signaling Positive Regulation Of Gene Expression Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Cellular Process Response To Abiotic Stimulus Immune System Process Regulation Of Nitrogen Compound Metabolic Process Developmental Process	Regulation Of Apoptotic Process Regulation Of Cell Death Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Intracellular Signal Transduction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signaling Neurotrophin Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Organic Substance Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Transport Regulation Of Cellular Localization Phosphorylation Regulation Of Cellular Process Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Protein Localization Cellular Response To Stress Regulation Of Cellular Protein Metabolic Process Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Signal Transduction Cellular Response To Stimulus Cell Communication Phosphate-containing Compound Metabolic Process
Tagcloud ?		abeta1 autophagic autophagosomes autophagy bcl2 beclin becn1 buildup digested elevation favor favoring flux hamper incompletely jnk1 jnk2 lc3 lysosomal mapk9 modifying monomers neuroblastoma oligomers phosphorylating profound sk turn vacuoles	androgen bak bax colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl
Tagcloud (Difference) ?		abeta1 autophagic autophagosomes autophagy bcl2 beclin becn1 buildup digested elevation favor favoring flux hamper incompletely jnk1 jnk2 lc3 lysosomal mapk9 modifying monomers neuroblastoma oligomers phosphorylating profound sk turn vacuoles	androgen bak bax colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl
Tagcloud (Intersection) ?