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MAPK8 and GANAB
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
MAPK8
GANAB
Gene Name
mitogen-activated protein kinase 8
glucosidase, alpha; neutral AB
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Mitochondrion
Cytosol
Endoplasmic Reticulum Lumen
Golgi Apparatus
Membrane
Glucosidase II Complex
Melanosome
Extracellular Vesicular Exosome
Molecular Function
Protein Serine/threonine Kinase Activity
JUN Kinase Activity
Protein Binding
ATP Binding
Enzyme Binding
Histone Deacetylase Regulator Activity
Histone Deacetylase Binding
Carbohydrate Binding
Glucan 1,3-alpha-glucosidase Activity
Poly(A) RNA Binding
Biological Process
Ossification
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Apoptotic Process
Response To Stress
JNK Cascade
JUN Phosphorylation
Response To UV
Positive Regulation Of Gene Expression
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Histone Deacetylation
Negative Regulation Of Protein Binding
Regulation Of Protein Localization
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Response To Cadmium Ion
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Stress-activated MAPK Cascade
Cellular Response To Hydrogen Peroxide
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Nitric Oxide
Positive Regulation Of Deacetylase Activity
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Programmed Necrotic Cell Death
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Determination Of Dorsal Identity
Protein Folding
Protein N-linked Glycosylation Via Asparagine
Post-translational Protein Modification
Cellular Protein Metabolic Process
Pathways
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
Activation of BH3-only proteins
FCERI mediated MAPK activation
Toll Like Receptor TLR6:TLR2 Cascade
Activation of BMF and translocation to mitochondria
Activated TLR4 signalling
Toll Like Receptor TLR1:TLR2 Cascade
Activation of the AP-1 family of transcription factors
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
Programmed Cell Death
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor 9 (TLR9) Cascade
Intrinsic Pathway for Apoptosis
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Innate Immune System
Signalling by NGF
Cell death signalling via NRAGE, NRIF and NADE
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
p75 NTR receptor-mediated signalling
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
DSCAM interactions
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
Activation of BIM and translocation to mitochondria
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
NRAGE signals death through JNK
Fc epsilon receptor (FCERI) signaling
MAPK targets/ Nuclear events mediated by MAP kinases
Defective ALG2 causes ALG2-CDG (CDG-1i)
Diseases of glycosylation
Defective ALG3 causes ALG3-CDG (CDG-1d)
Post-translational protein modification
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Defective ALG1 causes ALG1-CDG (CDG-1k)
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective ALG6 causes ALG6-CDG (CDG-1c)
Defective MOGS causes MOGS-CDG (CDG-2b)
Defective RFT1 causes RFT1-CDG (CDG-1n)
Asparagine N-linked glycosylation
Defective ALG8 causes ALG8-CDG (CDG-1h)
Defective ALG9 causes ALG9-CDG (CDG-1l)
Defective MAN1B1 causes MRT15
Defective MPDU1 causes MPDU1-CDG (CDG-1f)
Defective ALG12 causes ALG12-CDG (CDG-1g)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Defective ALG11 causes ALG11-CDG (CDG-1p)
Diseases associated with N-glycosylation of proteins
Calnexin/calreticulin cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions
134 interactors:
AIMP1
APLP2
APP
ATF2
BAD
BCL2
BCL2L1
BCL2L11
BMF
BMPR2
C11orf57
CAMP
CASP3
CBL
CCDC88C
CDKN1A
CDKN2A
CDKN2C
CEBPA
COPS2
CRK
CTNNB1
DUSP1
DUSP10
DUSP16
DUSP22
DUSP4
DUSP7
DUSP8
EEF2K
ELK1
ELK3
ELK4
EP300
ETV1
FAM193B
FZR1
GANAB
GARS
GEMIN5
GFPT1
GORASP2
GSTP1
GUCY1A3
HDAC9
HIVEP1
HRAS
HSD17B4
HSF1
HSF4
HSPA8
ID2
IKBKAP
IL27RA
IRAK1
IRF3
IRS1
ITCH
JDP2
JKAMP
JUN
JUNB
JUND
KRT8
MAP1B
MAP2K1
MAP2K2
MAP2K4
MAP2K7
MAP3K1
MAP3K2
MAP3K4
MAP3K7
MAPK1
MAPK14
MAPK3
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAP1
MAPKBP1
MAPT
MKNK2
MYC
NCOA3
NFATC3
NFATC4
NFE2
NR3C1
NR4A1
PAX2
PDPK1
PIAS2
PIK3R1
PKMYT1
PNRC1
PPARG
PRKD1
PRKDC
PXN
RAD18
RAF1
RASSF1
RBM15
REL
RET
RPLP2
RPS6KB1
SCAND1
SCOC
SERPINB3
SERPINB4
SH3BP5
SHC1
SIRT1
SMAD2
SMAD3
SNCG
SP1
SPAG9
SPI1
SPIB
SSU72
STAT3
TFCP2
TNFSF11
TP53
TP73
TRAF6
WDR62
WWOX
XRCC6
YWHAZ
ZNF219
7 interactors:
CCNH
CREB3L4
MAPK8
PRKCSH
PRRC2A
PTPRC
RAP1A
Entrez ID
5599
23193
HPRD ID
03100
03516
Ensembl ID
ENSG00000107643
ENSG00000089597
Uniprot IDs
A1L4K2
P45983
Q308M2
B4DIW2
B4DSM6
B4DZ53
E9PKU7
F5H6X6
Q14697
PDB IDs
1UKH
1UKI
2G01
2GMX
2H96
2NO3
2XRW
2XS0
3ELJ
3O17
3O2M
3PZE
3V3V
3VUD
3VUG
3VUH
3VUI
3VUK
3VUL
3VUM
4AWI
4E73
4G1W
4L7F
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Phosphorylation
Response To Stress
Regulation Of Phosphorus Metabolic Process
Intracellular Signal Transduction
Regulation Of Protein Phosphorylation
Positive Regulation Of Metabolic Process
Regulation Of Kinase Activity
Response To Organic Substance
Cellular Response To Organic Substance
Cellular Response To Growth Factor Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Protein Kinase Activity
Response To Growth Factor
Apoptotic Process
Cellular Response To Stimulus
Programmed Cell Death
Cellular Response To Stress
Signaling
Signal Transduction
Cell Death
Death
MAPK Cascade
Cell Communication
Positive Regulation Of Cellular Biosynthetic Process
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Signal Transduction By Phosphorylation
Negative Regulation Of Cellular Metabolic Process
Defense Response
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Stress-activated MAPK Cascade
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Signaling
Positive Regulation Of Gene Expression
Regulation Of MAP Kinase Activity
Innate Immune Response
Positive Regulation Of Signal Transduction
Response To Stimulus
Regulation Of Cellular Process
Response To Abiotic Stimulus
Immune System Process
Regulation Of Nitrogen Compound Metabolic Process
Developmental Process
Response To Stress
Positive Regulation Of Metabolic Process
Cellular Response To Stimulus
Immunoglobulin Biosynthetic Process
Positive Regulation Of Hematopoietic Stem Cell Migration
Regulation Of Protein Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Regulation Of Kinase Activity
Regulation Of Protein Metabolic Process
Positive Regulation Of Apoptotic Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
JUN Phosphorylation
Neurotrophin Signaling Pathway
Regulation Of Catalytic Activity
Positive Regulation Of Deacetylase Activity
Negative Regulation Of T Cell Mediated Cytotoxicity
Regulation Of Protein Phosphorylation
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Positive Regulation Of Isotype Switching To IgG Isotypes
Bone Marrow Development
Response To Stimulus
Positive Regulation Of Cellular Metabolic Process
Cell Cycle Phase Transition
Positive Regulation Of Determination Of Dorsal Identity
Activation Of Protein Kinase Activity
Positive Regulation Of Gamma-delta T Cell Differentiation
N-glycan Processing
Rap Protein Signal Transduction
Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration
Regulation Of Isotype Switching To IgG Isotypes
Positive Thymic T Cell Selection
Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Gamma-delta T Cell Activation
Regulation Of Phosphorylation
Negative Regulation Of Protein Autophosphorylation
Positive Regulation Of Vasculogenesis
Defense Response
Cellular Response To Nitric Oxide
Nerve Growth Factor Signaling Pathway
Regulation Of Gamma-delta T Cell Differentiation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Negative Regulation Of T Cell Mediated Immunity
Negative Thymic T Cell Selection
Signaling
Regulation Of Neuron Projection Development
Negative Regulation Of Synaptic Vesicle Exocytosis
Negative T Cell Selection
Response To Nitric Oxide
Positive Regulation Of Alpha-beta T Cell Proliferation
Tagcloud
?
abeta1
autophagic
autophagosomes
autophagy
bcl2
beclin
becn1
buildup
digested
elevation
favor
favoring
flux
hamper
incompletely
jnk1
jnk2
lc3
lysosomal
mapk9
modifying
monomers
neuroblastoma
oligomers
phosphorylating
profound
sk
turn
vacuoles
Tagcloud (Difference)
?
abeta1
autophagic
autophagosomes
autophagy
bcl2
beclin
becn1
buildup
digested
elevation
favor
favoring
flux
hamper
incompletely
jnk1
jnk2
lc3
lysosomal
mapk9
modifying
monomers
neuroblastoma
oligomers
phosphorylating
profound
sk
turn
vacuoles
Tagcloud (Intersection)
?