MAPK8 and HSF1

Number of citations of the paper that reports this interaction (PMID 10747973)
18

Data Source:
HPRD (in vitro, in vivo)

		MAPK8	HSF1
Gene Name		mitogen-activated protein kinase 8	heat shock transcription factor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol	Nucleoplasm Cytoplasm Cytosol Protein Complex Pronucleus
	Molecular Function	Protein Serine/threonine Kinase Activity JUN Kinase Activity Protein Binding ATP Binding Enzyme Binding Histone Deacetylase Regulator Activity Histone Deacetylase Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Ossification Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Apoptotic Process Response To Stress JNK Cascade JUN Phosphorylation Response To UV Positive Regulation Of Gene Expression Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Histone Deacetylation Negative Regulation Of Protein Binding Regulation Of Protein Localization Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Response To Cadmium Ion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Deacetylase Activity Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Placenta Development Transcription, DNA-templated Protein Phosphorylation Defense Response Female Meiotic Division Spermatogenesis Negative Regulation Of Cell Proliferation Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Heat Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Process Involved In Female Pregnancy Regulation Of Spindle Checkpoint Regulation Of Cellular Response To Heat
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence Activation of BH3-only proteins FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activation of BMF and translocation to mitochondria Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Programmed Cell Death MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Intrinsic Pathway for Apoptosis JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade DSCAM interactions NRIF signals cell death from the nucleus Oxidative Stress Induced Senescence Activation of BIM and translocation to mitochondria Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade NRAGE signals death through JNK Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases	HSF1 activation HSF1-dependent transactivation Attenuation phase Cellular response to heat stress Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS
Protein-Protein Interactions		134 interactors: AIMP1 APLP2 APP ATF2 BAD BCL2 BCL2L1 BCL2L11 BMF BMPR2 C11orf57 CAMP CASP3 CBL CCDC88C CDKN1A CDKN2A CDKN2C CEBPA COPS2 CRK CTNNB1 DUSP1 DUSP10 DUSP16 DUSP22 DUSP4 DUSP7 DUSP8 EEF2K ELK1 ELK3 ELK4 EP300 ETV1 FAM193B FZR1 GANAB GARS GEMIN5 GFPT1 GORASP2 GSTP1 GUCY1A3 HDAC9 HIVEP1 HRAS HSD17B4 HSF1 HSF4 HSPA8 ID2 IKBKAP IL27RA IRAK1 IRF3 IRS1 ITCH JDP2 JKAMP JUN JUNB JUND KRT8 MAP1B MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K1 MAP3K2 MAP3K4 MAP3K7 MAPK1 MAPK14 MAPK3 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAP1 MAPKBP1 MAPT MKNK2 MYC NCOA3 NFATC3 NFATC4 NFE2 NR3C1 NR4A1 PAX2 PDPK1 PIAS2 PIK3R1 PKMYT1 PNRC1 PPARG PRKD1 PRKDC PXN RAD18 RAF1 RASSF1 RBM15 REL RET RPLP2 RPS6KB1 SCAND1 SCOC SERPINB3 SERPINB4 SH3BP5 SHC1 SIRT1 SMAD2 SMAD3 SNCG SP1 SPAG9 SPI1 SPIB SSU72 STAT3 TFCP2 TNFSF11 TP53 TP73 TRAF6 WDR62 WWOX XRCC6 YWHAZ ZNF219	47 interactors: CAMK2A CDC20 CDK6 CEBPB CHST10 CREBBP CSNK2A1 DAXX DNAJB1 ENO2 FILIP1 FKBP4 FKBP5 GSK3A GTF2A2 GTF2B HSBP1 HSF2 HSPA1A HSPA8 MAPK1 MAPK3 MAPK8 MAPK9 MAPKAPK2 NCOA6 PLK1 PPID PRKDC PTGES3 RALBP1 REPS1 SMARCA4 STAT1 STUB1 SUB1 SUMO1 SUMO3 SYMPK TAF1 TAF7 TAF9 TBP UBE2I XRCC5 XRCC6 YWHAE
Entrez ID		5599	3297
HPRD ID		03100	00778
Ensembl ID		ENSG00000107643	ENSG00000185122
Uniprot IDs		A1L4K2 P45983 Q308M2	Q00613
PDB IDs		1UKH 1UKI 2G01 2GMX 2H96 2NO3 2XRW 2XS0 3ELJ 3O17 3O2M 3PZE 3V3V 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4AWI 4E73 4G1W 4L7F	2LDU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Phosphorylation Response To Stress Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Response To Organic Substance Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Kinase Activity Response To Growth Factor Apoptotic Process Cellular Response To Stimulus Programmed Cell Death Cellular Response To Stress Signaling Signal Transduction Cell Death Death MAPK Cascade Cell Communication Positive Regulation Of Cellular Biosynthetic Process Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Signal Transduction By Phosphorylation Negative Regulation Of Cellular Metabolic Process Defense Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signaling Positive Regulation Of Gene Expression Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Cellular Process Response To Abiotic Stimulus Immune System Process Regulation Of Nitrogen Compound Metabolic Process Developmental Process	Regulation Of Cellular Response To Heat Cellular Response To Heat Cellular Response To Stress Positive Regulation Of Metabolic Process Response To Heat Viral Process Response To Temperature Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Abiotic Stimulus Regulation Of Gene Expression Positive Regulation Of Gene Expression Peptidyl-amino Acid Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Chaperone-mediated Protein Folding Positive Regulation Of Transcription, DNA-templated Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Component Organization Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Negative Regulation Of Transcription, DNA-templated Cellular Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Gene Expression Innate Immune Response Cellular Protein Modification Process Regulation Of Cellular Process Peptidyl-serine Phosphorylation Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process
Tagcloud ?		abeta1 autophagic autophagosomes autophagy bcl2 beclin becn1 buildup digested elevation favor favoring flux hamper incompletely jnk1 jnk2 lc3 lysosomal mapk9 modifying monomers neuroblastoma oligomers phosphorylating profound sk turn vacuoles	atg cloned codon composed consensus contiguous derivatives dnaj element ends extension footprinting gaan heat homologue hse hses hsp40 intron minimal mobility motifs primer race sequences shock supershift transcripts upstream
Tagcloud (Difference) ?		abeta1 autophagic autophagosomes autophagy bcl2 beclin becn1 buildup digested elevation favor favoring flux hamper incompletely jnk1 jnk2 lc3 lysosomal mapk9 modifying monomers neuroblastoma oligomers phosphorylating profound sk turn vacuoles	atg cloned codon composed consensus contiguous derivatives dnaj element ends extension footprinting gaan heat homologue hse hses hsp40 intron minimal mobility motifs primer race sequences shock supershift transcripts upstream
Tagcloud (Intersection) ?