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MAPK8 and MAPK8IP2
Number of citations of the paper that reports this interaction (PMID
10490659
)
99
Data Source:
HPRD
(in vivo, in vitro)
MAPK8
MAPK8IP2
Gene Name
mitogen-activated protein kinase 8
mitogen-activated protein kinase 8 interacting protein 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Mitochondrion
Cytosol
Cytoplasm
Neuronal Cell Body
Protein Complex
Neuronal Postsynaptic Density
Molecular Function
Protein Serine/threonine Kinase Activity
JUN Kinase Activity
Protein Binding
ATP Binding
Enzyme Binding
Histone Deacetylase Regulator Activity
Histone Deacetylase Binding
Beta-amyloid Binding
MAP-kinase Scaffold Activity
Structural Molecule Activity
Protein Binding
Kinesin Binding
Protein Kinase Binding
Protein Kinase Activator Activity
Protein Complex Binding
Biological Process
Ossification
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Apoptotic Process
Response To Stress
JNK Cascade
JUN Phosphorylation
Response To UV
Positive Regulation Of Gene Expression
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Histone Deacetylation
Negative Regulation Of Protein Binding
Regulation Of Protein Localization
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Response To Cadmium Ion
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Stress-activated MAPK Cascade
Cellular Response To Hydrogen Peroxide
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Nitric Oxide
Positive Regulation Of Deacetylase Activity
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Programmed Necrotic Cell Death
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Determination Of Dorsal Identity
MAPK Cascade
Behavioral Fear Response
Signal Complex Assembly
JNK Cascade
Mating Behavior
Regulation Of Receptor Activity
Positive Regulation Of Stress-activated MAPK Cascade
Social Behavior
Positive Regulation Of Protein Kinase Activity
Regulation Of JNK Cascade
Nonassociative Learning
Dendrite Morphogenesis
Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Excitatory Postsynaptic Membrane Potential
Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity
Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
Activation of BH3-only proteins
FCERI mediated MAPK activation
Toll Like Receptor TLR6:TLR2 Cascade
Activation of BMF and translocation to mitochondria
Activated TLR4 signalling
Toll Like Receptor TLR1:TLR2 Cascade
Activation of the AP-1 family of transcription factors
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
Programmed Cell Death
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor 9 (TLR9) Cascade
Intrinsic Pathway for Apoptosis
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Innate Immune System
Signalling by NGF
Cell death signalling via NRAGE, NRIF and NADE
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
p75 NTR receptor-mediated signalling
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
DSCAM interactions
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
Activation of BIM and translocation to mitochondria
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
NRAGE signals death through JNK
Fc epsilon receptor (FCERI) signaling
MAPK targets/ Nuclear events mediated by MAP kinases
Drugs
Diseases
GWAS
Protein-Protein Interactions
134 interactors:
AIMP1
APLP2
APP
ATF2
BAD
BCL2
BCL2L1
BCL2L11
BMF
BMPR2
C11orf57
CAMP
CASP3
CBL
CCDC88C
CDKN1A
CDKN2A
CDKN2C
CEBPA
COPS2
CRK
CTNNB1
DUSP1
DUSP10
DUSP16
DUSP22
DUSP4
DUSP7
DUSP8
EEF2K
ELK1
ELK3
ELK4
EP300
ETV1
FAM193B
FZR1
GANAB
GARS
GEMIN5
GFPT1
GORASP2
GSTP1
GUCY1A3
HDAC9
HIVEP1
HRAS
HSD17B4
HSF1
HSF4
HSPA8
ID2
IKBKAP
IL27RA
IRAK1
IRF3
IRS1
ITCH
JDP2
JKAMP
JUN
JUNB
JUND
KRT8
MAP1B
MAP2K1
MAP2K2
MAP2K4
MAP2K7
MAP3K1
MAP3K2
MAP3K4
MAP3K7
MAPK1
MAPK14
MAPK3
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAP1
MAPKBP1
MAPT
MKNK2
MYC
NCOA3
NFATC3
NFATC4
NFE2
NR3C1
NR4A1
PAX2
PDPK1
PIAS2
PIK3R1
PKMYT1
PNRC1
PPARG
PRKD1
PRKDC
PXN
RAD18
RAF1
RASSF1
RBM15
REL
RET
RPLP2
RPS6KB1
SCAND1
SCOC
SERPINB3
SERPINB4
SH3BP5
SHC1
SIRT1
SMAD2
SMAD3
SNCG
SP1
SPAG9
SPI1
SPIB
SSU72
STAT3
TFCP2
TNFSF11
TP53
TP73
TRAF6
WDR62
WWOX
XRCC6
YWHAZ
ZNF219
52 interactors:
ADRB2
AFG3L2
APP
ASRGL1
BBS10
C14orf1
CFL1
CHN1
CRMP1
DUSP16
EGFR
ERBB2
EZH2
FGF12
FSCN1
GBP2
ITSN1
KIFC2
KLC1
LRP1
LRP2
LRP8
MAGED4B
MAP2K3
MAP2K7
MAP3K10
MAP3K11
MAP3K12
MAPK10
MAPK8
MAPK8IP1
MAPK8IP3
MAPK9
MASP1
NDUFS6
PLXNA3
PRSS23
RAI1
RBX1
RPS6KB2
SMARCB1
SMS
SYNE2
TIAM1
TP53BP2
UNC119
VCP
VPS33B
VRK2
YY1AP1
ZNF593
ZNF784
Entrez ID
5599
23542
HPRD ID
03100
09674
Ensembl ID
ENSG00000107643
ENSG00000008735
Uniprot IDs
A1L4K2
P45983
Q308M2
Q13387
PDB IDs
1UKH
1UKI
2G01
2GMX
2H96
2NO3
2XRW
2XS0
3ELJ
3O17
3O2M
3PZE
3V3V
3VUD
3VUG
3VUH
3VUI
3VUK
3VUL
3VUM
4AWI
4E73
4G1W
4L7F
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Phosphorylation
Response To Stress
Regulation Of Phosphorus Metabolic Process
Intracellular Signal Transduction
Regulation Of Protein Phosphorylation
Positive Regulation Of Metabolic Process
Regulation Of Kinase Activity
Response To Organic Substance
Cellular Response To Organic Substance
Cellular Response To Growth Factor Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Protein Kinase Activity
Response To Growth Factor
Apoptotic Process
Cellular Response To Stimulus
Programmed Cell Death
Cellular Response To Stress
Signaling
Signal Transduction
Cell Death
Death
MAPK Cascade
Cell Communication
Positive Regulation Of Cellular Biosynthetic Process
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Signal Transduction By Phosphorylation
Negative Regulation Of Cellular Metabolic Process
Defense Response
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Stress-activated MAPK Cascade
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Signaling
Positive Regulation Of Gene Expression
Regulation Of MAP Kinase Activity
Innate Immune Response
Positive Regulation Of Signal Transduction
Response To Stimulus
Regulation Of Cellular Process
Response To Abiotic Stimulus
Immune System Process
Regulation Of Nitrogen Compound Metabolic Process
Developmental Process
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
JNK Cascade
Signal Transduction By Phosphorylation
MAPK Cascade
Regulation Of Protein Kinase Activity
Regulation Of MAPK Cascade
Regulation Of Kinase Activity
Regulation Of Phosphorylation
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Kinase Activity
JUN Phosphorylation
Regulation Of MAP Kinase Activity
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Transferase Activity
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Positive Regulation Of Signal Transduction
Positive Regulation Of MAP Kinase Activity
Response To Stress
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of MAPK Cascade
Regulation Of Signal Transduction
Response To Light Stimulus
Response To External Stimulus
Response To Radiation
Regulation Of Signaling
Intracellular Signal Transduction
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Axon Guidance
Regulation Of Intracellular Signal Transduction
Signal Transduction
Axonogenesis
Phosphorylation
Cell Part Morphogenesis
Axon Development
Response To Stimulus
Cell Morphogenesis Involved In Neuron Differentiation
Response To Abiotic Stimulus
Protein Phosphorylation
Cellular Response To Stress
Signaling
Tagcloud
?
abeta1
autophagic
autophagosomes
autophagy
bcl2
beclin
becn1
buildup
digested
elevation
favor
favoring
flux
hamper
incompletely
jnk1
jnk2
lc3
lysosomal
mapk9
modifying
monomers
neuroblastoma
oligomers
phosphorylating
profound
sk
turn
vacuoles
Tagcloud (Difference)
?
abeta1
autophagic
autophagosomes
autophagy
bcl2
beclin
becn1
buildup
digested
elevation
favor
favoring
flux
hamper
incompletely
jnk1
jnk2
lc3
lysosomal
mapk9
modifying
monomers
neuroblastoma
oligomers
phosphorylating
profound
sk
turn
vacuoles
Tagcloud (Intersection)
?