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MAPK8 and PRKD1
Number of citations of the paper that reports this interaction (PubMedID
11948398
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
MAPK8
PRKD1
Description
mitogen-activated protein kinase 8
protein kinase D1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Axon
Synapse
Basal Dendrite
Autophagosome Membrane
Nucleus
Cytoplasm
Golgi Apparatus
Trans-Golgi Network
Cytosol
Plasma Membrane
Cell-cell Junction
Cell Cortex
Membrane
Z Disc
Perinuclear Region Of Cytoplasm
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Phosphatase Binding
Histone Deacetylase Regulator Activity
Histone Deacetylase Binding
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Heat Shock Protein Binding
Identical Protein Binding
Metal Ion Binding
Protein Serine Kinase Activity
Phosphatidylinositol 3-kinase Activator Activity
Biological Process
MAPK Cascade
Double-strand Break Repair
Protein Phosphorylation
Response To Oxidative Stress
JNK Cascade
JUN Phosphorylation
Response To UV
Response To Mechanical Stimulus
Positive Regulation Of Gene Expression
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Positive Regulation Of Cyclase Activity
Positive Regulation Of Cell Killing
Negative Regulation Of Protein Binding
Regulation Of Protein Localization
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Fc-epsilon Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of MRNA Stability
NLRP3 Inflammasome Complex Assembly
Rhythmic Process
Positive Regulation Of Protein Metabolic Process
Stress-activated MAPK Cascade
MRNA Destabilization
Protein Poly-ADP-ribosylation
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Senescence
Energy Homeostasis
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Establishment Of Protein Localization To Mitochondrion
Protein Localization To Site Of Double-strand Break
Angiogenesis
Positive Regulation Of Endothelial Cell Proliferation
Immune System Process
Apoptotic Process
Inflammatory Response
Golgi Organization
Signal Transduction
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Nervous System Development
Positive Regulation Of Autophagy
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Regulation Of Keratinocyte Proliferation
Positive Regulation Of Neuron Projection Development
Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril
Sphingolipid Biosynthetic Process
Cell Differentiation
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
Intracellular Signal Transduction
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Cell-cell Adhesion Mediated By Cadherin
Innate Immune Response
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Cell Size
Negative Regulation Of Endocytosis
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
Positive Regulation Of Protein Export From Nucleus
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Golgi Vesicle Transport
Defense Response To Gram-negative Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Sarcomere Organization
Transepithelial Transport
Cellular Response To Hydroperoxide
Response To Norepinephrine
Cellular Response To Norepinephrine Stimulus
Positive Regulation Of Peptide Hormone Secretion
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Cellular Response To Angiotensin
Cellular Response To Phorbol 13-acetate 12-myristate
Cellular Response To Endothelin
Positive Regulation Of Endothelial Cell Chemotaxis
Regulation Of Integrin-mediated Signaling Pathway
Pathways
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
NRAGE signals death through JNK
NRAGE signals death through JNK
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Interleukin-38 signaling
WNT5:FZD7-mediated leishmania damping
Signaling by ALK fusions and activated point mutants
Sphingolipid de novo biosynthesis
Drugs
Tamoxifen
Minocycline
Pyrazolanthrone
6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE
2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE
N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE
5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE
2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
Halicin
Bryostatin 1
Fostamatinib
Diseases
GWAS
Blood protein levels in cardiovascular risk (
28369058
)
Daytime sleep phenotypes (
27126917
)
Opioid dependence (time to event) (
34124712
)
Refractive error (
32231278
)
Academic attainment (English) (
33594131
)
Adult body size (
32376654
)
BMI (adjusted for smoking behaviour) (
28443625
)
Body mass index (
20935630
23669352
25673413
28552196
28448500
)
Body mass index (joint analysis main effects and physical activity interaction) (
28448500
)
Body mass index (joint analysis main effects and smoking interaction) (
28443625
)
Body mass index in physically active individuals (
28448500
)
Body size at age 10 (
32376654
)
California verbal learning test score (
31596458
)
Carotid plaque burden (
28282560
)
Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) (
26252872
)
Childhood body mass index (
26604143
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Daytime nap (
33568662
)
General cognitive ability (
29844566
)
General risk tolerance (MTAG) (
30643258
)
Hip circumference (
28552196
)
Household income (MTAG) (
31844048
)
IgM levels (
28628107
)
Intelligence (MTAG) (
29326435
)
Neurociticism (
29500382
)
Obesity-related traits (
23251661
)
Schizophrenia (
30285260
29483656
25056061
34099189
)
Spatial processing (
31596458
)
Systolic blood pressure (
30224653
)
Type 2 diabetes (
30130595
)
Urinary sodium excretion (
31409800
)
Waist circumference (
28552196
25673412
)
Weight (
28552196
)
Interacting Genes
140 interacting genes:
AIMP1
AKT1
APBB2
APLP2
APP
ATF2
ATM
BAD
BCL2
BCL2L1
BCL2L11
BMF
BMPR2
CAMP
CASP3
CBL
CCDC88C
CDKN1A
CDKN2A
CDKN2C
CEBPA
COPS2
CRK
CTNNB1
DUSP1
DUSP10
DUSP16
DUSP22
DUSP4
DUSP7
EEF2K
EGFR
ELK1
ELK3
ELK4
ELP1
EP300
ETV1
FAM193B
FZR1
GANAB
GARS1
GEMIN5
GFPT1
GORASP2
GSTP1
GUCY1A1
H2AX
HDAC9
HIVEP1
HRAS
HSD17B4
HSF1
HSF4
HSPA8
ID2
IL27RA
IRAK1
IRF3
IRS1
ITCH
JDP2
JKAMP
JUN
JUNB
JUND
KRT8
MAP1B
MAP2K1
MAP2K2
MAP2K4
MAP2K7
MAP3K2
MAP3K7
MAPK1
MAPK14
MAPK3
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAP1
MAPKBP1
MAPT
MBP
METTL3
MKNK2
MYC
NCOA3
NFATC3
NFATC4
NFE2
NFE2L2
NKAPD1
NR3C1
NR4A1
PAX2
PDPK1
PIAS2
PIK3R1
PKMYT1
PNRC1
PPARG
PRKD1
PRKDC
PXN
RAD18
RAF1
RASSF1
RBM15
REL
RET
RPLP2
RPS6KB1
SCAND1
SCOC
SERPINB3
SH3BP5
SHC1
SIRT1
SMAD2
SMAD3
SNCA
SNCG
SP1
SPAG9
SPI1
SPIB
SSU72
STAT3
TFCP2
TNFSF11
TP53
TP73
TRAF6
WDR62
WWOX
XRCC6
YWHAZ
ZNF219
ZNF605
33 interacting genes:
ABL1
ADAP1
AKAP13
BTK
C1QBP
COPS2
COPS5
COPS7A
EGFR
EPAS1
HDAC5
HDAC7
IBTK
IGF1R
JUN
KIDINS220
MAPK8
MAPK9
MT2A
NOS1
PLCG1
PLCG2
PPP1R14A
PRKCE
PRKCH
RACK1
SPRY2
SRC
SYK
TFAP2A
TP53
USP28
YWHAQ
Entrez ID
5599
5587
HPRD ID
03100
05668
Ensembl ID
ENSG00000107643
ENSG00000184304
Uniprot IDs
A1L4K2
P45983
F8WBA3
Q15139
PDB IDs
1UKH
1UKI
2G01
2GMX
2H96
2NO3
2XRW
2XS0
3ELJ
3O17
3O2M
3PZE
3V3V
3VUD
3VUG
3VUH
3VUI
3VUK
3VUL
3VUM
4AWI
4E73
4G1W
4HYS
4HYU
4IZY
4L7F
4QTD
4UX9
4YR8
5LW1
6F5E
6ZR5
8PT8
8PT9
8PTA
8R5E
8X5M
9FT9
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Intracellular Signaling Cassette
Regulation Of Intracellular Signal Transduction
Signal Transduction
MAPK Cascade
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Response To Stress
Regulation Of Primary Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Cellular Response To Stress
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Regulation Of Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
Cellular Developmental Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Response To Growth Factor
Regulation Of Signaling
Cellular Response To Oxygen-containing Compound
Regulation Of Cell Communication
Regulation Of DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Regulation Of MAPK Cascade
Regulation Of Transcription By RNA Polymerase II
Response To Lipid
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Nucleus
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Multicellular Organismal Process
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Signal Transduction
Response To Hormone
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Cell Surface Receptor Signaling Pathway
Programmed Cell Death
Cell Death
Regulation Of Cell Differentiation
Intracellular Signaling Cassette
Fc Receptor Signaling Pathway
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Positive Regulation Of Protein-containing Complex Assembly
Cytosol
Positive Regulation Of Cell Migration
Regulation Of Apoptotic Process
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Protein Metabolic Process
Regulation Of Protein Modification Process
Phosphorylation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Enzyme Binding
Signal Transduction
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
MAPK Cascade
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein-containing Complex
Negative Regulation Of Macromolecule Metabolic Process
Protein Phosphorylation
Regulation Of Post-translational Protein Modification
Positive Regulation Of Intracellular Signal Transduction
Kinase Activity
Protein Kinase C Binding
Response To Lipid
Regulation Of Cell Migration
Regulation Of Multicellular Organismal Process
Positive Regulation Of Epithelial Cell Migration
Protein Kinase Activity
Cell Activation
Regulation Of Protein Neddylation
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Cell Motility
Cellular Response To Growth Factor Stimulus
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Immune Response-regulating Signaling Pathway
Regulation Of Locomotion
Positive Regulation Of Programmed Cell Death
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Tagcloud (Intersection)
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