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MAPK8 and JUN
Number of citations of the paper that reports this interaction (PubMedID
8654373
)
56
Data Source:
HPRD
(in vitro, in vivo)
MAPK8
JUN
Description
mitogen-activated protein kinase 8
Jun proto-oncogene, AP-1 transcription factor subunit
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Axon
Synapse
Basal Dendrite
Nuclear Chromosome
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Transcription Repressor Complex
Transcription Factor AP-1 Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Phosphatase Binding
Histone Deacetylase Regulator Activity
Histone Deacetylase Binding
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
GTPase Activator Activity
Protein Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
CAMP Response Element Binding
Identical Protein Binding
Ubiquitin-like Protein Ligase Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
R-SMAD Binding
General Transcription Initiation Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
MAPK Cascade
Double-strand Break Repair
Protein Phosphorylation
Response To Oxidative Stress
JNK Cascade
JUN Phosphorylation
Response To UV
Response To Mechanical Stimulus
Positive Regulation Of Gene Expression
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Positive Regulation Of Cyclase Activity
Positive Regulation Of Cell Killing
Negative Regulation Of Protein Binding
Regulation Of Protein Localization
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Fc-epsilon Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of MRNA Stability
NLRP3 Inflammasome Complex Assembly
Rhythmic Process
Positive Regulation Of Protein Metabolic Process
Stress-activated MAPK Cascade
MRNA Destabilization
Protein Poly-ADP-ribosylation
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Senescence
Energy Homeostasis
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Establishment Of Protein Localization To Mitochondrion
Protein Localization To Site Of Double-strand Break
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Microglial Cell Activation
Liver Development
Positive Regulation Of Endothelial Cell Proliferation
Outflow Tract Morphogenesis
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
JNK Cascade
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Positive Regulation Of Epithelial Cell Migration
Release From Viral Latency
Monocyte Differentiation
Axon Regeneration
Response To Endoplasmic Reticulum Stress
Leading Edge Cell Differentiation
Response To Muscle Stretch
Regulation Of Cell Population Proliferation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Negative Regulation Of Neuron Apoptotic Process
Host-mediated Suppression Of Viral Transcription
Host-mediated Activation Of Viral Transcription
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
Response To Steroid Hormone
Regulation Of Cell Cycle
SMAD Protein Signal Transduction
Eyelid Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Calcium Ion
Cellular Response To Anisomycin
Integrated Stress Response Signaling
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of DNA-templated Transcription Initiation
Pathways
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
NRAGE signals death through JNK
NRAGE signals death through JNK
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Interleukin-38 signaling
WNT5:FZD7-mediated leishmania damping
Signaling by ALK fusions and activated point mutants
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated MAPK activation
Activation of the AP-1 family of transcription factors
Activation of anterior HOX genes in hindbrain development during early embryogenesis
MAPK6/MAPK4 signaling
TP53 Regulates Transcription of DNA Repair Genes
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
WNT5:FZD7-mediated leishmania damping
Signaling by ALK fusions and activated point mutants
Regulation of PD-L1(CD274) transcription
Drugs
Tamoxifen
Minocycline
Pyrazolanthrone
6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE
2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE
N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE
5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE
2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
Halicin
Adapalene
Vinblastine
Pseudoephedrine
Irbesartan
Arsenic trioxide
LGD-1550
Diseases
GWAS
Blood protein levels in cardiovascular risk (
28369058
)
Daytime sleep phenotypes (
27126917
)
Opioid dependence (time to event) (
34124712
)
Refractive error (
32231278
)
Aspartate aminotransferase levels (
33547301
)
Cognitive performance (
19734545
)
Night sleep phenotypes (
27126917
)
Interacting Genes
140 interacting genes:
AIMP1
AKT1
APBB2
APLP2
APP
ATF2
ATM
BAD
BCL2
BCL2L1
BCL2L11
BMF
BMPR2
CAMP
CASP3
CBL
CCDC88C
CDKN1A
CDKN2A
CDKN2C
CEBPA
COPS2
CRK
CTNNB1
DUSP1
DUSP10
DUSP16
DUSP22
DUSP4
DUSP7
EEF2K
EGFR
ELK1
ELK3
ELK4
ELP1
EP300
ETV1
FAM193B
FZR1
GANAB
GARS1
GEMIN5
GFPT1
GORASP2
GSTP1
GUCY1A1
H2AX
HDAC9
HIVEP1
HRAS
HSD17B4
HSF1
HSF4
HSPA8
ID2
IL27RA
IRAK1
IRF3
IRS1
ITCH
JDP2
JKAMP
JUN
JUNB
JUND
KRT8
MAP1B
MAP2K1
MAP2K2
MAP2K4
MAP2K7
MAP3K2
MAP3K7
MAPK1
MAPK14
MAPK3
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAP1
MAPKBP1
MAPT
MBP
METTL3
MKNK2
MYC
NCOA3
NFATC3
NFATC4
NFE2
NFE2L2
NKAPD1
NR3C1
NR4A1
PAX2
PDPK1
PIAS2
PIK3R1
PKMYT1
PNRC1
PPARG
PRKD1
PRKDC
PXN
RAD18
RAF1
RASSF1
RBM15
REL
RET
RPLP2
RPS6KB1
SCAND1
SCOC
SERPINB3
SH3BP5
SHC1
SIRT1
SMAD2
SMAD3
SNCA
SNCG
SP1
SPAG9
SPI1
SPIB
SSU72
STAT3
TFCP2
TNFSF11
TP53
TP73
TRAF6
WDR62
WWOX
XRCC6
YWHAZ
ZNF219
ZNF605
181 interacting genes:
ABL1
AKAP5
APLP2
APP
AR
ARRB1
ATF1
ATF2
ATF3
ATF4
BATF
BATF2
BBS7
BCL3
BCL6
BLM
BRCA1
CASP9
CCND1
CEBPE
CEBPG
CLINT1
COP1
COPS5
CREB3
CREB5
CREBBP
CSNK2A1
DACH1
DDIT3
DDX21
DHX9
DNMT3L
EDF1
EGR1
ELF3
ELOF1
EN1
EP300
EPAS1
ERG
ESR1
ETS1
ETS2
ETV1
ETV4
EWSR1
FBXW7
FOS
FOSL1
FOSL2
GATA2
GGA1
GGA2
GOPC
GSK3B
GTF2B
GTF2E2
GTF2F1
GTF2F2
HCFC1
HDAC3
HDAC9
HDGF
HHEX
HIF1A
HMGA1
HNRNPM
HOXA9
HOXC8
HSP90AA1
HSPA8
IKBKB
IRAK1
ITCH
ITPK1
JDP2
KLF5
KMT2C
KPNA2
M6PR
MACF1
MAF
MAFB
MAP2K4
MAP2K7
MAPK10
MAPK11
MAPK14
MAPK3
MAPK8
MAPK9
MAPKAPK5
MAPRE3
MBD3
MDM2
MECOM
MOK
MTA1
MYBBP1A
MYOD1
NACA
NAT14
NCOA1
NCOA2
NCOA3
NCOA6
NCOR2
NEDD4
NELFB
NFE2L1
NFE2L2
NFYA
NR3C1
NR5A1
NRIP1
NTRK3
PACS1
PHOX2A
PIAS1
PIAS2
PIN1
POU1F1
PPARG
PPP3CB
PPP4C
PRKD1
PRKDC
PRRC2A
RB1
RBM39
RELA
RNF187
RPL18A
RPS6KA2
RUNX1
RUNX2
SKI
SMAD2
SMAD3
SMAD4
SMARCD1
SMARCD3
SNAPC5
SNRK
SOX10
SOX8
SP1
SPI1
SPIB
STAT1
STAT3
STAT4
STRN4
SUMO1
SUMO2
SUMO3
SUMO4
TAF1
TAF4
TBP
TCF20
TCF4
TDG
TGIF1
TOP1
TOP2A
TP53
TPM1
TPM2
TRAF2
TRIP4
TSC22D3
TSG101
UBB
UBC
UBE2I
USP6
VAV1
VDR
ZBTB7C
Entrez ID
5599
3725
HPRD ID
03100
01302
Ensembl ID
ENSG00000107643
ENSG00000177606
Uniprot IDs
A1L4K2
P45983
P05412
PDB IDs
1UKH
1UKI
2G01
2GMX
2H96
2NO3
2XRW
2XS0
3ELJ
3O17
3O2M
3PZE
3V3V
3VUD
3VUG
3VUH
3VUI
3VUK
3VUL
3VUM
4AWI
4E73
4G1W
4HYS
4HYU
4IZY
4L7F
4QTD
4UX9
4YR8
5LW1
6F5E
6ZR5
8PT8
8PT9
8PTA
8R5E
8X5M
9FT9
1A02
1FOS
1JNM
1JUN
1S9K
1T2K
5FV8
5T01
6Y3V
8SOS
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Intracellular Signaling Cassette
Regulation Of Intracellular Signal Transduction
Signal Transduction
MAPK Cascade
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Response To Stress
Regulation Of Primary Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Cellular Response To Stress
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Regulation Of Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
Cellular Developmental Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Response To Growth Factor
Regulation Of Signaling
Cellular Response To Oxygen-containing Compound
Regulation Of Cell Communication
Regulation Of DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Regulation Of MAPK Cascade
Regulation Of Transcription By RNA Polymerase II
Response To Lipid
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Nucleus
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Multicellular Organismal Process
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Signal Transduction
Response To Hormone
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Cell Surface Receptor Signaling Pathway
Programmed Cell Death
Cell Death
Regulation Of Cell Differentiation
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Chromatin
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Nucleus
Nucleoplasm
Regulation Of Metabolic Process
DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
RNA Polymerase II Transcription Regulator Complex
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-templated Transcription
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Regulator Complex
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Cell Differentiation
Negative Regulation Of Biosynthetic Process
Sequence-specific DNA Binding
Transcription By RNA Polymerase II
Intracellular Signal Transduction
Negative Regulation Of Metabolic Process
Regulation Of Cell Differentiation
Cellular Developmental Process
Intracellular Signaling Cassette
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Nucleobase-containing Compound Biosynthetic Process
Tagcloud
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Tagcloud (Intersection)
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