MAPK8 and CAMP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MAPK8	CAMP
Gene Name		mitogen-activated protein kinase 8	cathelicidin antimicrobial peptide
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol	Extracellular Space Cell Wall Cytosol Specific Granule Cell Projection Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity JUN Kinase Activity Protein Binding ATP Binding Enzyme Binding Histone Deacetylase Regulator Activity Histone Deacetylase Binding	Protein Binding
	Biological Process	Ossification Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Apoptotic Process Response To Stress JNK Cascade JUN Phosphorylation Response To UV Positive Regulation Of Gene Expression Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Histone Deacetylation Negative Regulation Of Protein Binding Regulation Of Protein Localization Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Response To Cadmium Ion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Deacetylase Activity Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity	Positive Regulation Of Protein Phosphorylation Innate Immune Response In Mucosa Positive Regulation Of Cell Proliferation Antibacterial Humoral Response Defense Response To Bacterium Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Growth Of Symbiont On Or Near Host Surface Positive Regulation Of Angiogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Interaction With Host Killing By Host Of Symbiont Cells Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Phagosome Maturation
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence Activation of BH3-only proteins FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activation of BMF and translocation to mitochondria Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Programmed Cell Death MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Intrinsic Pathway for Apoptosis JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade DSCAM interactions NRIF signals cell death from the nucleus Oxidative Stress Induced Senescence Activation of BIM and translocation to mitochondria Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade NRAGE signals death through JNK Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases	Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		134 interactors: AIMP1 APLP2 APP ATF2 BAD BCL2 BCL2L1 BCL2L11 BMF BMPR2 C11orf57 CAMP CASP3 CBL CCDC88C CDKN1A CDKN2A CDKN2C CEBPA COPS2 CRK CTNNB1 DUSP1 DUSP10 DUSP16 DUSP22 DUSP4 DUSP7 DUSP8 EEF2K ELK1 ELK3 ELK4 EP300 ETV1 FAM193B FZR1 GANAB GARS GEMIN5 GFPT1 GORASP2 GSTP1 GUCY1A3 HDAC9 HIVEP1 HRAS HSD17B4 HSF1 HSF4 HSPA8 ID2 IKBKAP IL27RA IRAK1 IRF3 IRS1 ITCH JDP2 JKAMP JUN JUNB JUND KRT8 MAP1B MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K1 MAP3K2 MAP3K4 MAP3K7 MAPK1 MAPK14 MAPK3 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAP1 MAPKBP1 MAPT MKNK2 MYC NCOA3 NFATC3 NFATC4 NFE2 NR3C1 NR4A1 PAX2 PDPK1 PIAS2 PIK3R1 PKMYT1 PNRC1 PPARG PRKD1 PRKDC PXN RAD18 RAF1 RASSF1 RBM15 REL RET RPLP2 RPS6KB1 SCAND1 SCOC SERPINB3 SERPINB4 SH3BP5 SHC1 SIRT1 SMAD2 SMAD3 SNCG SP1 SPAG9 SPI1 SPIB SSU72 STAT3 TFCP2 TNFSF11 TP53 TP73 TRAF6 WDR62 WWOX XRCC6 YWHAZ ZNF219	6 interactors: CTSG ELANE FPR2 LBP MAPK8 PRTN3
Entrez ID		5599	820
HPRD ID		03100	02722
Ensembl ID		ENSG00000107643	ENSG00000164047
Uniprot IDs		A1L4K2 P45983 Q308M2	J3KNB4 P49913
PDB IDs		1UKH 1UKI 2G01 2GMX 2H96 2NO3 2XRW 2XS0 3ELJ 3O17 3O2M 3PZE 3V3V 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4AWI 4E73 4G1W 4L7F	2FBS 2FBU 2FCG 2K6O 2LMF 4EYC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Phosphorylation Response To Stress Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Response To Organic Substance Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Kinase Activity Response To Growth Factor Apoptotic Process Cellular Response To Stimulus Programmed Cell Death Cellular Response To Stress Signaling Signal Transduction Cell Death Death MAPK Cascade Cell Communication Positive Regulation Of Cellular Biosynthetic Process Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Signal Transduction By Phosphorylation Negative Regulation Of Cellular Metabolic Process Defense Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signaling Positive Regulation Of Gene Expression Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Cellular Process Response To Abiotic Stimulus Immune System Process Regulation Of Nitrogen Compound Metabolic Process Developmental Process	Negative Regulation Of Growth Of Symbiont In Host Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Killing By Host Of Symbiont Cells Response To Bacterium Defense Response Positive Regulation Of Immune Response Defense Response To Bacterium Response To Stress Neutrophil Mediated Immunity Response To Other Organism Response To Biotic Stimulus Killing Of Cells Of Other Organism Response To External Stimulus Defense Response To Fungus Negative Regulation Of Growth Response To Lipid Positive Regulation Of Interleukin-8 Production Regulation Of Immune Response Interaction With Symbiont Leukocyte Mediated Cytotoxicity Positive Regulation Of Immune System Process Immune System Process Response To Fungus Regulation Of Chemokine Production Collagen Catabolic Process Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of Cytokine Biosynthetic Process Immune Response Regulation Of Immune System Process Acute Inflammatory Response Collagen Metabolic Process Toll-like Receptor 4 Signaling Pathway Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Toll-like Receptor Signaling Pathway Regulation Of Cytokine Biosynthetic Process Regulation Of Growth Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To UV Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Lipopolysaccharide Transport Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Regulation Of Chemotaxis Activation Of Innate Immune Response
Tagcloud ?		abeta1 autophagic autophagosomes autophagy bcl2 beclin becn1 buildup digested elevation favor favoring flux hamper incompletely jnk1 jnk2 lc3 lysosomal mapk9 modifying monomers neuroblastoma oligomers phosphorylating profound sk turn vacuoles	2cl adh admittance antidiuretic ascending augment basolateral basolaterally bilayers channels cl clc conductance ctal cytosolic excised faces gate gated gating k1 ka microperfused mtal pka po rbclc rises thick threefold
Tagcloud (Difference) ?		abeta1 autophagic autophagosomes autophagy bcl2 beclin becn1 buildup digested elevation favor favoring flux hamper incompletely jnk1 jnk2 lc3 lysosomal mapk9 modifying monomers neuroblastoma oligomers phosphorylating profound sk turn vacuoles	2cl adh admittance antidiuretic ascending augment basolateral basolaterally bilayers channels cl clc conductance ctal cytosolic excised faces gate gated gating k1 ka microperfused mtal pka po rbclc rises thick threefold
Tagcloud (Intersection) ?