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DCAF6 and TRIM63
Number of citations of the paper that reports this interaction (PMID
18157088
)
41
Data Source:
BioGRID
(two hybrid)
DCAF6
TRIM63
Gene Name
DDB1 and CUL4 associated factor 6
tripartite motif containing 63, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Focal Adhesion
Cul4-RING E3 Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Microtubule
Z Disc
M Band
Molecular Function
Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Signal Transducer Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Titin Binding
Biological Process
Protein Ubiquitination
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Muscle Contraction
Signal Transduction
Regulation Of Gene Expression
Skeletal Muscle Atrophy
Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Response To Interleukin-1
Cellular Response To Dexamethasone Stimulus
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Schizophrenia (
22037555
)
Protein-Protein Interactions
9 interactors:
ACVR1
AR
BMPR1B
NR3C1
SMAD2
SUPT5H
TGFBR1
TRIM55
TRIM63
87 interactors:
ACTA1
AK1
AKR7A2
ALDOA
ANKRD1
APP
ATP5B
ATXN3
ATXN3L
BAP1
CKB
CKM
DCAF6
DES
EEF1G
EHHADH
EIF3E
ENO3
ESPL1
FHL2
FLNC
GFM1
GMEB1
HIBADH
JOSD1
LMCD1
MRPL19
MRPL41
MYBPC1
MYBPC3
MYL2
MYOT
MYOZ1
NDUFA1
NEB
NEBL
NOMO1
NRAP
OTUB1
OTUB2
PDHB
PDK4
PIAS1
PIAS2
PIAS3
PKM
PSMD4
PYGM
SENP2
SENP3
SQSTM1
SRF
STAM
SUMO2
TCAP
TNNC1
TNNI1
TNNI2
TNNI3
TNNT1
TNNT3
TRIM54
TRIM55
TTN
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2I
UBE2J1
UBE2U
UCHL1
UCHL3
UCHL5
UQCRC1
USP13
USP15
USP2
USP21
USP28
USP33
USP4
USP5
USP7
USP8
UXT
YOD1
Entrez ID
55827
84676
HPRD ID
17156
05843
Ensembl ID
ENSG00000143164
ENSG00000158022
Uniprot IDs
Q58WW2
B4DN95
Q969Q1
PDB IDs
3I7O
2D8U
3DDT
Enriched GO Terms of Interacting Partners
?
Activin Receptor Signaling Pathway
Cellular Response To Organic Cyclic Compound
Response To Lipid
Response To Organic Cyclic Compound
Cellular Response To Steroid Hormone Stimulus
Regulation Of Extrinsic Apoptotic Signaling Pathway
Cellular Response To Glucocorticoid Stimulus
Cellular Response To Corticosteroid Stimulus
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Response To Organic Substance
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Urogenital System Development
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Pathway-restricted SMAD Protein Phosphorylation
Cellular Response To Lipid
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Organ Morphogenesis
Regulation Of Transcription From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Organic Substance
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pharyngeal System Development
Response To Steroid Hormone
Pattern Specification Process
Response To Glucocorticoid
Negative Regulation Of Signal Transduction
Regulation Of Gene Expression
Response To Corticosteroid
Response To Cholesterol
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of Activin Receptor Signaling Pathway
Negative Regulation Of Signaling
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Cellular Response To Hormone Stimulus
Signal Transduction
Mesenchyme Development
Reproductive Process
DNA-templated Transcription, Initiation
Response To Stimulus
Signaling
Cell Communication
Regulation Of Apoptotic Process
Stem Cell Development
Developmental Process Involved In Reproduction
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Protein Modification By Small Protein Removal
Muscle Filament Sliding
Actin-myosin Filament Sliding
Protein Deubiquitination
Actin-mediated Cell Contraction
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Actin Filament-based Movement
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Protein K48-linked Deubiquitination
Proteolysis
Muscle Contraction
Regulation Of Proteasomal Protein Catabolic Process
Catabolic Process
Muscle System Process
Regulation Of Protein Catabolic Process
Actin Filament-based Process
Protein K63-linked Deubiquitination
Striated Muscle Cell Development
Striated Muscle Contraction
Muscle Cell Development
Muscle Structure Development
Myofibril Assembly
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Regulation Of Proteolysis
Cardiac Muscle Tissue Morphogenesis
Striated Muscle Cell Differentiation
Muscle Tissue Morphogenesis
Cardiac Muscle Tissue Development
Muscle Organ Morphogenesis
Actomyosin Structure Organization
Protein Sumoylation
Protein Metabolic Process
Striated Muscle Tissue Development
Muscle Cell Differentiation
Muscle Tissue Development
Regulation Of Muscle Contraction
Protein Modification By Small Protein Conjugation
Muscle Organ Development
Heart Morphogenesis
Regulation Of Cellular Protein Metabolic Process
Cardiac Myofibril Assembly
Muscle Fiber Development
Monoubiquitinated Protein Deubiquitination
Tagcloud
?
benzylic
bioactivation
clues
covalent
danger
dapk1
hapten
hepatotoxicity
il22
inflammasome
marks
methide
nevirapine
nlrp3
nvp
obligate
oh
oxidized
presumably
quinone
ra2
rash
rashes
reflecting
s100a7
s100a7a
sulfate
travels
Tagcloud (Difference)
?
benzylic
bioactivation
clues
covalent
danger
dapk1
hapten
hepatotoxicity
il22
inflammasome
marks
methide
nevirapine
nlrp3
nvp
obligate
oh
oxidized
presumably
quinone
ra2
rash
rashes
reflecting
s100a7
s100a7a
sulfate
travels
Tagcloud (Intersection)
?