DCAF6

Description		DDB1 and CUL4 associated factor 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding
	Biological Process	Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Neddylation
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Schizophrenia ( 22037555)
Interacting Genes		14 interacting genes: ACVR1 AR BMPR1B CLIP4 CTBP1 CTBP2 DSCR9 GTF2IRD1 NR3C1 SMAD2 SUPT5H TGFBR1 TRIM55 TRIM63
Entrez ID		55827
HPRD ID		17156
Ensembl ID		ENSG00000143164
Uniprot IDs		Q58WW2
PDB IDs		3I7O
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Activity, Type I SMAD Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Activin Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Response To Growth Factor Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Complex Activin Receptor Activity, Type I Tissue Morphogenesis Trophoblast Cell Migration Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition BMP Receptor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Transcription By RNA Polymerase II Response To Transforming Growth Factor Beta Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Activin Binding Positive Regulation Of Macromolecule Biosynthetic Process Estrogen Response Element Binding In Utero Embryonic Development Chordate Embryonic Development Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regionalization Negative Regulation Of RNA Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway White Fat Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Pharyngeal System Development Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction
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