DCAF6 and CLIP4

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		DCAF6	CLIP4
Description		DDB1 and CUL4 associated factor 6	CAP-Gly domain containing linker protein family member 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Cell Cortex Microtubule Plus-end
	Molecular Function	Transcription Coactivator Activity Protein Binding	Protein Binding Microtubule Plus-end Binding
	Biological Process	Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II	Cytoplasmic Microtubule Organization
Pathways		Neddylation
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Schizophrenia ( 22037555)	Metabolite levels ( 23823483)
Interacting Genes		14 interacting genes: ACVR1 AR BMPR1B CLIP4 CTBP1 CTBP2 DSCR9 GTF2IRD1 NR3C1 SMAD2 SUPT5H TGFBR1 TRIM55 TRIM63	37 interacting genes: APP CDK5RAP2 CLIP1 CMYA5 DCAF6 DES DST DYNC2LI1 GLP1R HSF2BP JAKMIP2 KIF1B KIFC3 LZTS2 MAGEA12 MAP7 MAP7D1 MEOX2 MYBPC1 MYH3 PDE4DIP PEG10 RPS13 RPS27L RUNX1 SIX2 SON TACC3 TAF1 TNNT1 TNNT3 TPM1 TRIM32 TRIP13 TTN TULP3 ZNF114
Entrez ID		55827	79745
HPRD ID		17156	08634
Ensembl ID		ENSG00000143164	ENSG00000115295
Uniprot IDs		Q58WW2	A0A8I5KXU9 A0A8I5QKP4 A0A8I5QKV0 A8K6D0 B7Z936 G3XAK3 Q8N3C7
PDB IDs		3I7O	2Z0W
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Activity, Type I SMAD Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Activin Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Response To Growth Factor Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Complex Activin Receptor Activity, Type I Tissue Morphogenesis Trophoblast Cell Migration Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition BMP Receptor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Transcription By RNA Polymerase II Response To Transforming Growth Factor Beta Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Activin Binding Positive Regulation Of Macromolecule Biosynthetic Process Estrogen Response Element Binding In Utero Embryonic Development Chordate Embryonic Development Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regionalization Negative Regulation Of RNA Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway White Fat Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Pharyngeal System Development Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction	Cytoskeleton Organization Sarcomere Organization Organelle Organization Microtubule-based Process Microtubule Cytoskeleton Organization Actomyosin Structure Organization Microtubule Skeletal Muscle Contraction Striated Muscle Contraction Microtubule Binding Muscle Filament Sliding Muscle Contraction Actin-myosin Filament Sliding Centrosome Actin Cytoskeleton Organization Cytoskeleton Microtubule Plus-end Microtubule Cytoskeleton Muscle System Process M Band Actin Filament-based Process Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Microtubule Polymerization Actin-mediated Cell Contraction Female Meiosis I Structural Constituent Of Muscle Troponin Complex Myofibril Male Meiotic Nuclear Division Regulation Of Supramolecular Fiber Organization Actin Filament-based Movement Contractile Muscle Fiber Tropomyosin Binding Regulation Of Microtubule Polymerization Cytoskeletal Protein Binding Regulation Of Microtubule Cytoskeleton Organization Transport Along Microtubule Meiotic Nuclear Division Female Meiotic Nuclear Division Axo-dendritic Transport Positive Regulation Of Cytoskeleton Organization Supramolecular Fiber Organization Retrograde Axonal Transport Microtubule Plus-end Binding Positive Regulation Of Protein Polymerization Cytoskeleton-dependent Intracellular Transport Myosin Filament Nuclear Division Regulation Of Cytoskeleton Organization Amyloid-beta Complex
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