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TSG101 and HCK
Number of citations of the paper that reports this interaction (PubMedID
12029088
)
0
Data Source:
HPRD
(in vitro)
TSG101
HCK
Description
tumor susceptibility 101
HCK proto-oncogene, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
ESCRT I Complex
Nucleus
Nucleolus
Cytoplasm
Endosome
Early Endosome
Late Endosome
Multivesicular Body
Centrosome
Cytosol
Cytoskeleton
Plasma Membrane
Endosome Membrane
Membrane
Early Endosome Membrane
Late Endosome Membrane
Extracellular Exosome
Flemming Body
Nucleus
Cytoplasm
Lysosome
Golgi Apparatus
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Caveola
Focal Adhesion
Cytoplasmic Side Of Plasma Membrane
Membrane
Transport Vesicle
Cytoplasmic Vesicle
Cell Projection
Membrane Raft
Anchoring Junction
Molecular Function
DNA Binding
Transcription Corepressor Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Protein Homodimerization Activity
Ubiquitin Binding
Protein-containing Complex Binding
Virion Binding
Calcium-dependent Protein Binding
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Lipid Binding
Kinase Activity
Transferase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Growth
Extracellular Transport
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Cell Population Proliferation
Endosome To Lysosome Transport
Protein Transport
Macroautophagy
Viral Release From Host Cell
Cell Differentiation
Keratinocyte Differentiation
Multivesicular Body Assembly
Viral Budding Via Host ESCRT Complex
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Regulation Of MAP Kinase Activity
Viral Budding
Cell Division
Regulation Of Cell Cycle
Membrane Fission
Autophagosome Maturation
Positive Regulation Of Exosomal Secretion
Regulation Of Extracellular Exosome Assembly
Positive Regulation Of Viral Budding Via Host ESCRT Complex
Exosomal Secretion
Positive Regulation Of Ubiquitin-dependent Endocytosis
Immune System Process
Leukocyte Migration Involved In Immune Response
Innate Immune Response-activating Signaling Pathway
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Protein Phosphorylation
Exocytosis
Phagocytosis
Response To Stress
Inflammatory Response
Cell Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Mesoderm Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Positive Regulation Of Actin Filament Polymerization
Lipopolysaccharide-mediated Signaling Pathway
Regulation Of Actin Cytoskeleton Organization
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Apoptotic Process
Leukocyte Degranulation
Innate Immune Response
Respiratory Burst After Phagocytosis
Protein Autophosphorylation
Regulation Of Inflammatory Response
Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Leukocyte Migration
Regulation Of DNA-binding Transcription Factor Activity
Type II Interferon-mediated Signaling Pathway
Cellular Response To Lipid
Regulation Of Podosome Assembly
Pathways
Budding and maturation of HIV virion
Membrane binding and targetting of GAG proteins
Endosomal Sorting Complex Required For Transport (ESCRT)
HCMV Late Events
Late endosomal microautophagy
Nef and signal transduction
FCGR activation
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Signaling by CSF1 (M-CSF) in myeloid cells
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
FLT3 signaling through SRC family kinases
Drugs
1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Phosphonotyrosine
Quercetin
Bosutinib
Fostamatinib
Diseases
GWAS
Adult body size (
32376654
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Inflammatory bowel disease (
23128233
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Migraine (
27322543
)
Interacting Genes
136 interacting genes:
AATF
ADRB2
AJUBA
AKAP9
AR
BAG4
BCAS3
BCR
BIRC2
CAGE1
CBY1
CCDC88B
CCHCR1
CCND3
CDKN1A
CDKN2D
CDS2
CEP55
CEP63
CHD7
CNOT7
DAXX
DMAP1
DMRTB1
DNMT1
DSCR9
DZIP3
EP300
FAM110A
FAM9B
GGA1
GGA3
GLI2
GLIS3
GMCL1
GOLM1
GPRC5B
GUCY1B2
HAUS1
HCK
HGS
HSH2D
INCA1
IQGAP1
IRF2BPL
ITPRID2
ITSN1
JUN
KIAA1328
KIF5A
KIFC3
KLK5
KLK6
KRT13
KRT15
KRT16
KRT18
KRT31
KRT34
KRT35
KRT75
LCN2
LENG8
LNX1
LRRFIP1
LRSAM1
MDM2
MGRN1
MKRN3
MTA3
MZB1
NR3C1
NUP214
OGT
PDCD6IP
PDLIM7
PIAS1
PIP4P2
PKNOX2
PPFIBP2
PPP1R13B
PRDM16
PRRC1
PRSS50
QKI
RAD18
RASL10B
RBPMS
RNF111
RNF126
RNF41
ROCK1
SCAMP3
SCARA5
SCGB3A1
SCNN1A
SH3GLB2
SHANK3
SNAPIN
SNCA
SNF8
SNX32
STK11
SYCE1
TAX1BP1
TEX11
TFF1
TFIP11
THRB
THRSP
TNF
TNIP2
TNNT3
TOM1L1
TP53
TRAIP
TRIM23
TRIM35
TRIM46
TRIM54
TRIM74
TRIML2
UBA52
UBC
USF3
USHBP1
VPS11
VPS28
VPS36
VPS37A
VPS37B
VPS37C
VPS37D
WASHC1
YLPM1
ZWINT
117 interacting genes:
ABL1
ABL2
ACTB
ADAM15
AGK
AGR2
APP
AR
ARRB1
ASAP1
BCAR1
BCR
BPIFA1
BTK
CBL
CCDC88B
CCR3
CD2AP
CHST15
CREBBP
CSF2RB
CSF3R
CSK
CTAG1A
CTAG1B
CYB5D2
CYSRT1
DNM2
DOK1
DOK2
EGFR
ELMO1
ERBB2
ERBB3
ERBB4
EVL
FASLG
FCGR1A
FCGR2A
FHL2
FHL5
GAB1
GOPC
GRB14
HNRNPK
HSF2BP
IL6ST
INCA1
INPP5D
IRF2BPL
KHDRBS1
KIT
KPRP
KRT31
KRT34
KRT35
KRT36
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP3-1
LCP2
LETMD1
LMNA
MAP4K5
MDK
MDM2
MET
MID2
MKRN3
MTUS2
NBPF19
NGEF
NOTCH2NLA
PAK2
PECAM1
PIK3CB
PIK3R1
PIK3R2
PLAUR
PLCG1
PLCG2
PLEKHG4
PNMA1
PRRG4
RAPGEF1
RASA1
RASA3
RBPMS
RPL10
SF3B3
SH2B2
SH3BP1
SH3KBP1
SKAP2
SOS1
SPRR2A
STAT3
TEKT4
TEPSIN
TNK2
TOX2
TP73
TRIM27
TRIP6
TRPV4
TSG101
UNC119
VAV1
WAS
WDCP
WIPF1
WNT2
ZSCAN4
Entrez ID
7251
3055
HPRD ID
03229
00796
Ensembl ID
ENSG00000074319
ENSG00000101336
Uniprot IDs
Q99816
A8K4G3
P08631
PDB IDs
1KPP
1KPQ
1M4P
1M4Q
1S1Q
2F0R
3IV1
3OBQ
3OBS
3OBU
3OBX
3P9G
3P9H
4EJE
4YC1
4ZNY
5VKG
6UD0
6VME
7NLC
7ZLX
1AD5
1BU1
1QCF
2C0I
2C0O
2C0T
2HCK
2HK5
2OI3
2OJ2
3HCK
3NHN
3RBB
3REA
3REB
3VRY
3VRZ
3VS0
3VS1
3VS2
3VS3
3VS4
3VS5
3VS6
3VS7
4HCK
4LUD
4LUE
4ORZ
4U5W
5H09
5H0B
5H0E
5H0G
5H0H
5HCK
5NUH
5ZJ6
8F2P
9BYJ
Enriched GO Terms of Interacting Partners
?
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Multivesicular Body Organization
Multivesicular Body Assembly
Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway
Endosome Transport Via Multivesicular Body Sorting Pathway
Vacuolar Transport
Ubiquitin Protein Ligase Activity
Multivesicular Body Sorting Pathway
Autophagy
Cytosol
Late Endosome To Vacuole Transport
Viral Budding
Endosome Organization
Establishment Of Protein Localization To Vacuole
Intracellular Protein Localization
Membrane Fission
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Protein Localization To Vacuole
Organelle Organization
ESCRT I Complex
Viral Budding Via Host ESCRT Complex
Programmed Cell Death
Cell Death
Endosomal Transport
Intracellular Protein Transport
Macroautophagy
Zinc Ion Binding
Protein Ubiquitination
Protein Transport
Vesicle-mediated Transport
Protein Modification By Small Protein Conjugation
Apoptotic Process
Establishment Of Protein Localization
Cellular Localization
Cytoplasm
Cytoskeleton
Structural Constituent Of Skin Epidermis
Endosome Membrane
Protein Binding
Intracellular Transport
Protein Localization To Organelle
Intermediate Filament Cytoskeleton Organization
Keratin Filament
Intermediate Filament-based Process
Ubiquitin Binding
Intermediate Filament Organization
Positive Regulation Of Catabolic Process
Regulation Of Protein Metabolic Process
Viral Process
Post-translational Protein Modification
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
SH3 Domain Binding
Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Regulation Of Endocytosis
Intracellular Signaling Cassette
Cytosol
Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Supramolecular Fiber Organization
Regulation Of Programmed Cell Death
Regulation Of Intracellular Signal Transduction
Keratin Filament
Immune Response-regulating Signaling Pathway
Protein Tyrosine Kinase Activity
ERBB Signaling Pathway
Fc Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Positive Regulation Of Immune System Process
Protein Binding
Regulation Of Signal Transduction
Antigen Receptor-mediated Signaling Pathway
Phosphotyrosine Residue Binding
Intermediate Filament
Regulation Of Immune System Process
Plasma Membrane
Regulation Of Apoptotic Process
Regulation Of Small GTPase Mediated Signal Transduction
Immune Response-activating Signaling Pathway
T Cell Receptor Signaling Pathway
Regulation Of Vesicle-mediated Transport
Negative Regulation Of Programmed Cell Death
Cell-cell Junction
Developmental Process
Regulation Of Cell Motility
Regulation Of Immune Response
Actin Filament Organization
Activation Of Immune Response
Regulation Of Cell Communication
Regulation Of Signaling
Response To Growth Factor
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Regulation Of Locomotion
Identical Protein Binding
Endocytosis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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