TSG101 and GGA3

Number of citations of the paper that reports this interaction (PMID 15039775)
66

Data Source:
HPRD (in vitro, two hybrid)

		TSG101	GGA3
Gene Name		tumor susceptibility 101	golgi-associated, gamma adaptin ear containing, ARF binding protein 3
Image
Gene Ontology Annotations	Cellular Component	ESCRT I Complex Nucleolus Cytoplasm Early Endosome Late Endosome Multivesicular Body Plasma Membrane Endosome Membrane Late Endosome Membrane Extracellular Vesicular Exosome	Trans-Golgi Network Endosome Membrane Clathrin Adaptor Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Calcium-dependent Protein Binding	Protein Binding ADP-ribosylation Factor Binding
	Biological Process	Regulation Of Cell Growth Cellular Protein Modification Process Cell Cycle Arrest Negative Regulation Of Cell Proliferation Protein Transport Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Keratinocyte Differentiation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription, DNA-templated Viral Budding Cell Division Membrane Organization Intracellular Transport Of Virus Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Vesicular Exosome Assembly	Intracellular Protein Transport Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process
Pathways		Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		69 interactors: AATF ADRB2 AKAP9 AR ARRDC1 BCR BIRC2 CDKN1A CDS2 CEP55 DAXX DMAP1 DNMT1 DZIP3 EP300 FAM9B GGA1 GGA3 GMCL1 HAUS1 HCK HCRP1 HGS IQGAP1 ITSN1 JUN KIF5A KIFC3 KRT13 KRT15 KRT31 LRSAM1 MDM2 MGRN1 MKRN3 MVB12A NR3C1 PDCD6IP PDLIM7 PPFIBP2 RAD18 RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCNN1A SNF8 SYCE1 TAX1BP1 THRB TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM74 UBA52 UBAP1 USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D	24 interactors: AFTPH AP1S2 ARF1 ARF3 BACE1 CDKN2A CLINT1 CLTC GGA1 GGA2 IGF2R M6PR PACS1 RAB5A RABEP1 RNF11 RPS27A STAB1 SYNRG TBC1D3 TSG101 UBC VPS11 VPS18
Entrez ID		7251	23163
HPRD ID		03229	10443
Ensembl ID		ENSG00000074319	ENSG00000125447
Uniprot IDs		Q99816	A8K6I6 A8K6M0 Q9NZ52
PDB IDs		1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE	1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8
Enriched GO Terms of Interacting Partners?		Virion Assembly Viral Protein Processing Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosomal Transport Establishment Of Protein Localization Intracellular Transport Of Virus Viral Process Protein Transport Protein Localization Protein Catabolic Process Intracellular Transport Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Establishment Of Localization In Cell Viral Life Cycle Protein Ubiquitination Apoptotic Process Cellular Localization Protein Modification By Small Protein Conjugation Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Cell Death Enzyme Linked Receptor Protein Signaling Pathway Modification-dependent Protein Catabolic Process Death Protein Polyubiquitination Cellular Macromolecule Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Organization Apoptotic Signaling Pathway Transport Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Regulation Of Protein Metabolic Process Vacuolar Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Apoptotic Process Protein Processing Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Regulation Of Cell Death Response To Lipid Signal Transduction By P53 Class Mediator	Vesicle-mediated Transport Protein Transport Establishment Of Protein Localization Intracellular Transport Protein Localization Establishment Of Localization In Cell Transport Cellular Localization Intracellular Protein Transport Membrane Organization Viral Protein Processing Endocytosis Cellular Protein Localization Viral Process Virion Assembly Post-Golgi Vesicle-mediated Transport Endosomal Transport Regulation Of Defense Response To Virus By Virus Intracellular Transport Of Virus Antigen Processing And Presentation Of Peptide Antigen Golgi Vesicle Transport Antigen Processing And Presentation Receptor-mediated Endocytosis Viral Life Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle Arrest Membrane Budding Regulation Of Defense Response To Virus Protein Processing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Ubiquitin-protein Transferase Activity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Cell Cycle Arrest Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Notch Receptor Processing Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Regulation Of Vesicle-mediated Transport G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Receptor Internalization Negative Regulation Of Cell Cycle Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Ubiquitination
Tagcloud ?		000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle	acylation adaptin adaptors anchored apart cargo catalytically dileucine doi endosome governing hyperubiquitinated implicate itch knocked ll localizes onc participating publication put really recruits ribosylation rnf11 traffic ubiquitination vhs
Tagcloud (Difference) ?		000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle	acylation adaptin adaptors anchored apart cargo catalytically dileucine doi endosome governing hyperubiquitinated implicate itch knocked ll localizes onc participating publication put really recruits ribosylation rnf11 traffic ubiquitination vhs
Tagcloud (Intersection) ?