TSG101 and GPRC5B

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		TSG101	GPRC5B
Description		tumor susceptibility 101	G protein-coupled receptor class C group 5 member B
Image			No pdb structure
GO Annotations	Cellular Component	ESCRT I Complex Nucleus Nucleolus Cytoplasm Endosome Early Endosome Late Endosome Multivesicular Body Centrosome Cytosol Cytoskeleton Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane Extracellular Exosome Flemming Body	Extracellular Space Nucleoplasm Nucleolus Cytosol Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Receptor Complex Membrane Raft Extracellular Exosome
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Protein-containing Complex Binding Virion Binding Calcium-dependent Protein Binding	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Protein Kinase Binding Protein Kinase Activator Activity Protein Tyrosine Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Extracellular Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Population Proliferation Endosome To Lysosome Transport Protein Transport Macroautophagy Viral Release From Host Cell Cell Differentiation Keratinocyte Differentiation Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Viral Budding Cell Division Regulation Of Cell Cycle Membrane Fission Autophagosome Maturation Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Viral Budding Via Host ESCRT Complex Exosomal Secretion Positive Regulation Of Ubiquitin-dependent Endocytosis	Cell Volume Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS			Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Birth weight ( 31043758) Body mass index ( 20935630 25673413 26961502 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005) Hip circumference ( 25673412) L-selectin levels ( 25576479) Menarche (age at onset) ( 25231870) Obesity ( 23563607) Obesity-related traits ( 23251661) Waist circumference ( 25673412)
Interacting Genes		136 interacting genes: AATF ADRB2 AJUBA AKAP9 AR BAG4 BCAS3 BCR BIRC2 CAGE1 CBY1 CCDC88B CCHCR1 CCND3 CDKN1A CDKN2D CDS2 CEP55 CEP63 CHD7 CNOT7 DAXX DMAP1 DMRTB1 DNMT1 DSCR9 DZIP3 EP300 FAM110A FAM9B GGA1 GGA3 GLI2 GLIS3 GMCL1 GOLM1 GPRC5B GUCY1B2 HAUS1 HCK HGS HSH2D INCA1 IQGAP1 IRF2BPL ITPRID2 ITSN1 JUN KIAA1328 KIF5A KIFC3 KLK5 KLK6 KRT13 KRT15 KRT16 KRT18 KRT31 KRT34 KRT35 KRT75 LCN2 LENG8 LNX1 LRRFIP1 LRSAM1 MDM2 MGRN1 MKRN3 MTA3 MZB1 NR3C1 NUP214 OGT PDCD6IP PDLIM7 PIAS1 PIP4P2 PKNOX2 PPFIBP2 PPP1R13B PRDM16 PRRC1 PRSS50 QKI RAD18 RASL10B RBPMS RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCARA5 SCGB3A1 SCNN1A SH3GLB2 SHANK3 SNAPIN SNCA SNF8 SNX32 STK11 SYCE1 TAX1BP1 TEX11 TFF1 TFIP11 THRB THRSP TNF TNIP2 TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM54 TRIM74 TRIML2 UBA52 UBC USF3 USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D WASHC1 YLPM1 ZWINT	6 interacting genes: ADRB2 C11orf71 FUCA2 HTR2C TMEM120A TSG101
Entrez ID		7251	51704
HPRD ID		03229	16177
Ensembl ID		ENSG00000074319	ENSG00000167191
Uniprot IDs		Q99816	B7Z831 Q9NZH0
PDB IDs		1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE 4YC1 4ZNY 5VKG 6UD0 6VME 7NLC 7ZLX
Enriched GO Terms of Interacting Partners?		Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Vacuolar Transport Ubiquitin Protein Ligase Activity Multivesicular Body Sorting Pathway Autophagy Cytosol Late Endosome To Vacuole Transport Viral Budding Endosome Organization Establishment Of Protein Localization To Vacuole Intracellular Protein Localization Membrane Fission Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Localization To Vacuole Organelle Organization ESCRT I Complex Viral Budding Via Host ESCRT Complex Programmed Cell Death Cell Death Endosomal Transport Intracellular Protein Transport Macroautophagy Zinc Ion Binding Protein Ubiquitination Protein Transport Vesicle-mediated Transport Protein Modification By Small Protein Conjugation Apoptotic Process Establishment Of Protein Localization Cellular Localization Cytoplasm Cytoskeleton Structural Constituent Of Skin Epidermis Endosome Membrane Protein Binding Intracellular Transport Protein Localization To Organelle Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Ubiquitin Binding Intermediate Filament Organization Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Viral Process Post-translational Protein Modification	Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Fat Cell Differentiation Beta-adrenergic Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Nervous System Process Lysosomal Transport Endosome To Lysosome Transport Positive Regulation Of Mini Excitatory Postsynaptic Potential Beta2-adrenergic Receptor Activity Alpha-L-fucosidase Activity HSP90-CDC37 Chaperone Complex Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Positive Regulation Of Ubiquitin-dependent Endocytosis Positive Regulation Of Viral Budding Via Host ESCRT Complex Response To Psychosocial Stress Norepinephrine Binding Vacuolar Transport Positive Regulation Of Lipophagy Response To Temperature Stimulus AMPA Selective Glutamate Receptor Signaling Pathway Biological Process Involved In Interaction With Host G Protein-coupled Serotonin Receptor Complex Regulation Of Corticotropin-releasing Hormone Secretion Exosomal Secretion Coenzyme A Binding Protein Homodimerization Activity Receptor Ligand Inhibitor Activity Telomerase Holoenzyme Complex Assembly Regulation Of Extracellular Exosome Assembly Positive Regulation Of Autophagosome Maturation Heat Generation Regulation Of Entry Of Bacterium Into Host Cell Glycoside Catabolic Process ATP-dependent Protein Binding Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Aryl Hydrocarbon Receptor Complex Phospholipase C-activating Serotonin Receptor Signaling Pathway Adrenergic Receptor Activity Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Diet Induced Thermogenesis Serotonin Binding Serotonin Receptor Signaling Pathway Virion Binding Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Adhesion Of Symbiont To Host Cell
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