TSG101 and PKNOX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSG101	PKNOX2
Description		tumor susceptibility 101	PBX/knotted 1 homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	ESCRT I Complex Nucleus Nucleolus Cytoplasm Endosome Early Endosome Late Endosome Multivesicular Body Centrosome Cytosol Cytoskeleton Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane Extracellular Exosome Flemming Body	Nucleus Nucleoplasm Cytoplasm Actin Cytoskeleton Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Protein-containing Complex Binding Virion Binding Calcium-dependent Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Actin Monomer Binding Protein Binding Sequence-specific DNA Binding Actin Filament Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Extracellular Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Population Proliferation Endosome To Lysosome Transport Protein Transport Macroautophagy Viral Release From Host Cell Cell Differentiation Keratinocyte Differentiation Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Viral Budding Cell Division Regulation Of Cell Cycle Membrane Fission Autophagosome Maturation Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Viral Budding Via Host ESCRT Complex Exosomal Secretion Positive Regulation Of Ubiquitin-dependent Endocytosis	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS			Alcohol and nicotine co-dependence ( 22488850) Alcohol dependence ( 21703634 21956439) Alcohol dependence symptom count ( 27151647) Alzheimer's disease (survival time) ( 25649651) Breast cancer (survival) ( 25890600) Dimensional psychopathology (Social) ( 29496196) Disease progression in age-related macular degeneration ( 29346644) Formal thought disorder in schizophrenia ( 22648509) Heel bone mineral density ( 30598549) LDL cholesterol levels in HIV infection ( 33109212) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Prostate cancer ( 29892016) Schizophrenia ( 22688191) Serum uric acid levels in response to allopurinol in gout ( 25676789) Sleep duration ( 25469926) Substance dependence ( 21298047) Testicular germ cell tumor ( 28604728)
Interacting Genes		136 interacting genes: AATF ADRB2 AJUBA AKAP9 AR BAG4 BCAS3 BCR BIRC2 CAGE1 CBY1 CCDC88B CCHCR1 CCND3 CDKN1A CDKN2D CDS2 CEP55 CEP63 CHD7 CNOT7 DAXX DMAP1 DMRTB1 DNMT1 DSCR9 DZIP3 EP300 FAM110A FAM9B GGA1 GGA3 GLI2 GLIS3 GMCL1 GOLM1 GPRC5B GUCY1B2 HAUS1 HCK HGS HSH2D INCA1 IQGAP1 IRF2BPL ITPRID2 ITSN1 JUN KIAA1328 KIF5A KIFC3 KLK5 KLK6 KRT13 KRT15 KRT16 KRT18 KRT31 KRT34 KRT35 KRT75 LCN2 LENG8 LNX1 LRRFIP1 LRSAM1 MDM2 MGRN1 MKRN3 MTA3 MZB1 NR3C1 NUP214 OGT PDCD6IP PDLIM7 PIAS1 PIP4P2 PKNOX2 PPFIBP2 PPP1R13B PRDM16 PRRC1 PRSS50 QKI RAD18 RASL10B RBPMS RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCARA5 SCGB3A1 SCNN1A SH3GLB2 SHANK3 SNAPIN SNCA SNF8 SNX32 STK11 SYCE1 TAX1BP1 TEX11 TFF1 TFIP11 THRB THRSP TNF TNIP2 TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM54 TRIM74 TRIML2 UBA52 UBC USF3 USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D WASHC1 YLPM1 ZWINT	32 interacting genes: ARFIP2 C10orf88 C1orf216 CCDC116 CCDC185 CCDC196 CENPP CREBL2 CSTF2T CTTNBP2 CTTNBP2NL DDA1 ENKD1 FAM110B FHL2 HGS HOXB1 IQGAP1 MBD3 MCRS1 MYO15B NRIP1 NUP54 NUP58 PICK1 SMARCD1 STK16 TRIB3 TSG101 USHBP1 VPS37C YAP1
Entrez ID		7251	63876
HPRD ID		03229	17857
Ensembl ID		ENSG00000074319	ENSG00000165495
Uniprot IDs		Q99816	B7ZAF3 Q96KN3
PDB IDs		1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE 4YC1 4ZNY 5VKG 6UD0 6VME 7NLC 7ZLX
Enriched GO Terms of Interacting Partners?		Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Vacuolar Transport Ubiquitin Protein Ligase Activity Multivesicular Body Sorting Pathway Autophagy Cytosol Late Endosome To Vacuole Transport Viral Budding Endosome Organization Establishment Of Protein Localization To Vacuole Intracellular Protein Localization Membrane Fission Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Localization To Vacuole Organelle Organization ESCRT I Complex Viral Budding Via Host ESCRT Complex Programmed Cell Death Cell Death Endosomal Transport Intracellular Protein Transport Macroautophagy Zinc Ion Binding Protein Ubiquitination Protein Transport Vesicle-mediated Transport Protein Modification By Small Protein Conjugation Apoptotic Process Establishment Of Protein Localization Cellular Localization Cytoplasm Cytoskeleton Structural Constituent Of Skin Epidermis Endosome Membrane Protein Binding Intracellular Transport Protein Localization To Organelle Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Ubiquitin Binding Intermediate Filament Organization Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Viral Process Post-translational Protein Modification	Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Membrane Curvature Sensor Activity Transcription Corepressor Activity Late Endosome To Vacuole Transport Protein Domain Specific Binding Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway ESCRT I Complex Establishment Of Protein Localization To Vacuole Macroautophagy Regulation Of MAP Kinase Activity Positive Regulation Of Exosomal Secretion Intracellular Protein Transport FAR/SIN/STRIPAK Complex Endosome Organization Regulation Of Exosomal Secretion Protein Localization To Vacuole Viral Budding Via Host ESCRT Complex Structural Constituent Of Nuclear Pore Viral Budding
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