TSG101 and ROCK1

Number of citations of the paper that reports this interaction (PubMedID 17853893)
52

Data Source:
HPRD (two hybrid, in vitro)

		TSG101	ROCK1
Description		tumor susceptibility 101	Rho associated coiled-coil containing protein kinase 1
Image
GO Annotations	Cellular Component	ESCRT I Complex Nucleus Nucleolus Cytoplasm Endosome Early Endosome Late Endosome Multivesicular Body Centrosome Cytosol Cytoskeleton Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane Extracellular Exosome Flemming Body	Golgi Membrane Ruffle Extracellular Region Cytoplasm Golgi Apparatus Centriole Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Stress Granule Membrane Lamellipodium Bleb Secretory Granule Lumen Cell Projection Schaffer Collateral - CA1 Synapse
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Protein-containing Complex Binding Virion Binding Calcium-dependent Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Small GTPase Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Rho-dependent Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Extracellular Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Population Proliferation Endosome To Lysosome Transport Protein Transport Macroautophagy Viral Release From Host Cell Cell Differentiation Keratinocyte Differentiation Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Viral Budding Cell Division Regulation Of Cell Cycle Membrane Fission Autophagosome Maturation Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Viral Budding Via Host ESCRT Complex Exosomal Secretion Positive Regulation Of Ubiquitin-dependent Endocytosis	Mitotic Cytokinesis Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Apical Constriction Apoptotic Process Smooth Muscle Contraction Leukocyte Cell-cell Adhesion Signal Transduction Rho Protein Signal Transduction Regulation Of Gene Expression Positive Regulation Of Autophagy Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Peptidyl-serine Phosphorylation Membrane To Membrane Docking Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of Cell Migration Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Neuron Projection Development Bleb Assembly Negative Regulation Of Protein Binding Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Keratinocyte Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Phosphate Metabolic Process Embryonic Morphogenesis Leukocyte Migration Leukocyte Tethering Or Rolling Negative Regulation Of Membrane Protein Ectodomain Proteolysis Myoblast Migration Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Assembly MRNA Destabilization Negative Regulation Of Biomineral Tissue Development Regulation Of Microtubule Cytoskeleton Organization Response To Transforming Growth Factor Beta Protein Localization To Plasma Membrane Regulation Of Synapse Maturation Podocyte Cell Migration Motor Neuron Apoptotic Process Blood Vessel Diameter Maintenance Regulation Of Angiotensin-activated Signaling Pathway Neuron Projection Arborization Positive Regulation Of Amyloid-beta Clearance Regulation Of Synaptic Vesicle Endocytosis Regulation Of Cell Junction Assembly Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Connective Tissue Replacement Response To Angiotensin Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Apoptotic cleavage of cellular proteins EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RHOH GTPase cycle RHOBTB1 GTPase cycle Potential therapeutics for SARS RND3 GTPase cycle
Drugs			Hydroxyfasudil (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE Fasudil Y-27632 Ripasudil Netarsudil Belumosudil
Diseases
GWAS			Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Lysophosphatidylcholine levels ( 31551469) Telomere length ( 30185882)
Interacting Genes		136 interacting genes: AATF ADRB2 AJUBA AKAP9 AR BAG4 BCAS3 BCR BIRC2 CAGE1 CBY1 CCDC88B CCHCR1 CCND3 CDKN1A CDKN2D CDS2 CEP55 CEP63 CHD7 CNOT7 DAXX DMAP1 DMRTB1 DNMT1 DSCR9 DZIP3 EP300 FAM110A FAM9B GGA1 GGA3 GLI2 GLIS3 GMCL1 GOLM1 GPRC5B GUCY1B2 HAUS1 HCK HGS HSH2D INCA1 IQGAP1 IRF2BPL ITPRID2 ITSN1 JUN KIAA1328 KIF5A KIFC3 KLK5 KLK6 KRT13 KRT15 KRT16 KRT18 KRT31 KRT34 KRT35 KRT75 LCN2 LENG8 LNX1 LRRFIP1 LRSAM1 MDM2 MGRN1 MKRN3 MTA3 MZB1 NR3C1 NUP214 OGT PDCD6IP PDLIM7 PIAS1 PIP4P2 PKNOX2 PPFIBP2 PPP1R13B PRDM16 PRRC1 PRSS50 QKI RAD18 RASL10B RBPMS RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCARA5 SCGB3A1 SCNN1A SH3GLB2 SHANK3 SNAPIN SNCA SNF8 SNX32 STK11 SYCE1 TAX1BP1 TEX11 TFF1 TFIP11 THRB THRSP TNF TNIP2 TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM54 TRIM74 TRIML2 UBA52 UBC USF3 USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D WASHC1 YLPM1 ZWINT	40 interacting genes: ADD1 ARHGAP24 CASP3 CASP7 CDC25A CDC34 CFAP206 CRMP1 DES DPYSL2 EZR FAM124A GFAP HMGB2 IKBKB IRS1 ITSN2 LIMK1 LIMK2 LINC00452 LMO2 MAGEB4 MLC1 MSN PFN2 POLR3C PPP1R12A PTK2 RDX RHOA RHOB RHOC RND3 SMAD2 SMAD5 TPPP TRIM15 TSG101 UBE2T VIM
Entrez ID		7251	6093
HPRD ID		03229	03414
Ensembl ID		ENSG00000074319	ENSG00000067900
Uniprot IDs		Q99816	Q13464
PDB IDs		1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE 4YC1 4ZNY 5VKG 6UD0 6VME 7NLC 7ZLX	1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S 4L2W 4W7P 4YVC 4YVE 5BML 5F5P 5HVU 5KKS 5KKT 5UZJ 5WNE 5WNF 5WNG 5WNH 6E9W 7JOU 7S25 7S26 8P0S 8ZH5
Enriched GO Terms of Interacting Partners?		Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Vacuolar Transport Ubiquitin Protein Ligase Activity Multivesicular Body Sorting Pathway Autophagy Cytosol Late Endosome To Vacuole Transport Viral Budding Endosome Organization Establishment Of Protein Localization To Vacuole Intracellular Protein Localization Membrane Fission Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Localization To Vacuole Organelle Organization ESCRT I Complex Viral Budding Via Host ESCRT Complex Programmed Cell Death Cell Death Endosomal Transport Intracellular Protein Transport Macroautophagy Zinc Ion Binding Protein Ubiquitination Protein Transport Vesicle-mediated Transport Protein Modification By Small Protein Conjugation Apoptotic Process Establishment Of Protein Localization Cellular Localization Cytoplasm Cytoskeleton Structural Constituent Of Skin Epidermis Endosome Membrane Protein Binding Intracellular Transport Protein Localization To Organelle Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Ubiquitin Binding Intermediate Filament Organization Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Viral Process Post-translational Protein Modification	Focal Adhesion Cytoskeleton Supramolecular Fiber Organization Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Cytoskeleton Organization Cytoplasm Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Organelle Organization Astral Microtubule Organization Regulation Of Actin Filament-based Process Actin Filament Organization Positive Regulation Of Protein Localization To Endosome Negative Regulation Of Cell Projection Organization Regulation Of Protein-containing Complex Assembly Skeletal Muscle Satellite Cell Migration Positive Regulation Of Stress Fiber Assembly Cleavage Furrow Establishment Of Epithelial Cell Apical/basal Polarity Protein Kinase Binding Regulation Of Establishment Of Endothelial Barrier Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Actin Filament Bundle Assembly Actin Filament Bundle Assembly Cytoplasmic Microtubule Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Actin Filament Bundle Organization Actin Cytoskeleton Organization Developmental Process Establishment Of Apical/basal Cell Polarity Regulation Of Cell Projection Organization Intracellular Signaling Cassette Polarized Epithelial Cell Differentiation Cytoskeletal Protein Binding Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cellular Component Size Regulation Of Organelle Assembly Negative Regulation Of Cellular Component Organization Regulation Of Actin Filament Organization Cellular Developmental Process Cellular Response To Staurosporine Cell Differentiation Actin Filament-based Process Wound Healing, Spreading Of Cells Establishment Of Epithelial Cell Polarity Regulation Of Adherens Junction Organization
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