TSG101 and GLIS3

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (unspecified method)

		TSG101	GLIS3
Description		tumor susceptibility 101	GLIS family zinc finger 3
Image			No pdb structure
GO Annotations	Cellular Component	ESCRT I Complex Nucleus Nucleolus Cytoplasm Endosome Early Endosome Late Endosome Multivesicular Body Centrosome Cytosol Cytoskeleton Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane Extracellular Exosome Flemming Body	Nucleus
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Protein-containing Complex Binding Virion Binding Calcium-dependent Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Extracellular Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Population Proliferation Endosome To Lysosome Transport Protein Transport Macroautophagy Viral Release From Host Cell Cell Differentiation Keratinocyte Differentiation Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Viral Budding Cell Division Regulation Of Cell Cycle Membrane Fission Autophagosome Maturation Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Viral Budding Via Host ESCRT Complex Exosomal Secretion Positive Regulation Of Ubiquitin-dependent Endocytosis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases			Permanent neonatal diabetes mellitus (PNDM)
GWAS			Alzheimer's disease biomarkers ( 23562540) Anxiety ( 33859377) Appendicular lean mass ( 33097823) Blood sugar levels ( 29403010) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 29760442 32528159) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Chin dimples ( 27182965) Chronic obstructive pulmonary disease ( 30804561) Circulating leptin levels or type 2 diabetes ( 32341051) Fasting blood glucose ( 25631608 33842983 22581228 20081858) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting insulin ( 34059833) Fasting plasma glucose ( 25187374) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Glaucoma (primary angle closure) ( 27064256) Height ( 28552196) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Homeostasis model assessment of beta-cell function ( 20081858) Intraocular pressure ( 30591961 30054594 29785010 29617998 29235454) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low hand grip strength (60 years and older) (FNIH) ( 33510174) Low high density lipoprotein cholesterol levels ( 26879886) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Methotrexate pharmacokinetics (acute lymphoblastic leukemia) ( 19901119) Monocyte count ( 32888494) Neurociticism ( 29500382) Nicotine dependence ( 28440896) Non-HDL cholesterol levels ( 32902719) Offspring birth weight ( 31043758) Osteoarthritis of the hip or knee ( 29436472) Osteoarthritis of the hip or knee (with total joint replacement) ( 29436472) Peak expiratory flow ( 30804560) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Platelet count ( 32888494) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Spontaneous preterm birth (preterm delivery) ( 25599974) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Total cholesterol levels ( 32902719) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 1 diabetes ( 25751624 33830302 19430480 18840781) Type 2 diabetes ( 24509480 32499647 26818947 22961080 30718926 30297969 22885922 22158537 30054458 28869590) Vaginal microbiome composition (community state type) ( 32723796) White blood cell count ( 32888494)
Interacting Genes		136 interacting genes: AATF ADRB2 AJUBA AKAP9 AR BAG4 BCAS3 BCR BIRC2 CAGE1 CBY1 CCDC88B CCHCR1 CCND3 CDKN1A CDKN2D CDS2 CEP55 CEP63 CHD7 CNOT7 DAXX DMAP1 DMRTB1 DNMT1 DSCR9 DZIP3 EP300 FAM110A FAM9B GGA1 GGA3 GLI2 GLIS3 GMCL1 GOLM1 GPRC5B GUCY1B2 HAUS1 HCK HGS HSH2D INCA1 IQGAP1 IRF2BPL ITPRID2 ITSN1 JUN KIAA1328 KIF5A KIFC3 KLK5 KLK6 KRT13 KRT15 KRT16 KRT18 KRT31 KRT34 KRT35 KRT75 LCN2 LENG8 LNX1 LRRFIP1 LRSAM1 MDM2 MGRN1 MKRN3 MTA3 MZB1 NR3C1 NUP214 OGT PDCD6IP PDLIM7 PIAS1 PIP4P2 PKNOX2 PPFIBP2 PPP1R13B PRDM16 PRRC1 PRSS50 QKI RAD18 RASL10B RBPMS RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCARA5 SCGB3A1 SCNN1A SH3GLB2 SHANK3 SNAPIN SNCA SNF8 SNX32 STK11 SYCE1 TAX1BP1 TEX11 TFF1 TFIP11 THRB THRSP TNF TNIP2 TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM54 TRIM74 TRIML2 UBA52 UBC USF3 USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D WASHC1 YLPM1 ZWINT	14 interacting genes: BAG3 CIB1 CLNK ENO1 ITCH KRTAP6-1 NEK6 SUFU TRAF1 TRIB3 TRIP6 TSG101 UBC YAP1
Entrez ID		7251	169792
HPRD ID		03229	13582
Ensembl ID		ENSG00000074319	ENSG00000107249
Uniprot IDs		Q99816	A0A0S2Z689 Q1PHJ8 Q8NEA6
PDB IDs		1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE 4YC1 4ZNY 5VKG 6UD0 6VME 7NLC 7ZLX
Enriched GO Terms of Interacting Partners?		Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Vacuolar Transport Ubiquitin Protein Ligase Activity Multivesicular Body Sorting Pathway Autophagy Cytosol Late Endosome To Vacuole Transport Viral Budding Endosome Organization Establishment Of Protein Localization To Vacuole Intracellular Protein Localization Membrane Fission Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Localization To Vacuole Organelle Organization ESCRT I Complex Viral Budding Via Host ESCRT Complex Programmed Cell Death Cell Death Endosomal Transport Intracellular Protein Transport Macroautophagy Zinc Ion Binding Protein Ubiquitination Protein Transport Vesicle-mediated Transport Protein Modification By Small Protein Conjugation Apoptotic Process Establishment Of Protein Localization Cellular Localization Cytoplasm Cytoskeleton Structural Constituent Of Skin Epidermis Endosome Membrane Protein Binding Intracellular Transport Protein Localization To Organelle Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Ubiquitin Binding Intermediate Filament Organization Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Viral Process Post-translational Protein Modification	Transcription Corepressor Activity Ubiquitin Protein Ligase Binding Regulation Of Cell Growth Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cytosol Cell Death Programmed Cell Death Apoptotic Process Regulation Of Growth Negative Regulation Of Cell Communication Negative Regulation Of Signaling Canonical Glycolysis Regulation Of Protein Serine/threonine Kinase Activity Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Protein Serine/threonine Kinase Inhibitor Activity Glucose Catabolic Process Regulation Of Protein Localization To Nucleus Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Localization Negative Regulation Of Apoptotic Process ADP Catabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Magnesium Ion Binding Purine Ribonucleoside Diphosphate Catabolic Process Cytoplasm Negative Regulation Of Transcription By RNA Polymerase II Glycolytic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Transcription Corepressor Binding Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Enterocyte Differentiation Positive Regulation Of Male Germ Cell Proliferation Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Fat Cell Differentiation ADP Metabolic Process Regulation Of Phosphorus Metabolic Process
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