TSG101 and SCAMP3

Number of citations of the paper that reports this interaction (PMID 19158374)
15

Data Source:
HPRD (in vitro)

		TSG101	SCAMP3
Gene Name		tumor susceptibility 101	secretory carrier membrane protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	ESCRT I Complex Nucleolus Cytoplasm Early Endosome Late Endosome Multivesicular Body Plasma Membrane Endosome Membrane Late Endosome Membrane Extracellular Vesicular Exosome	Golgi Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Calcium-dependent Protein Binding	Ubiquitin Protein Ligase Binding
	Biological Process	Regulation Of Cell Growth Cellular Protein Modification Process Cell Cycle Arrest Negative Regulation Of Cell Proliferation Protein Transport Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Keratinocyte Differentiation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription, DNA-templated Viral Budding Cell Division Membrane Organization Intracellular Transport Of Virus Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Vesicular Exosome Assembly	Post-Golgi Vesicle-mediated Transport Protein Transport Response To Retinoic Acid
Pathways		Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS			Crohn's disease ( 21102463)
Protein-Protein Interactions		69 interactors: AATF ADRB2 AKAP9 AR ARRDC1 BCR BIRC2 CDKN1A CDS2 CEP55 DAXX DMAP1 DNMT1 DZIP3 EP300 FAM9B GGA1 GGA3 GMCL1 HAUS1 HCK HCRP1 HGS IQGAP1 ITSN1 JUN KIF5A KIFC3 KRT13 KRT15 KRT31 LRSAM1 MDM2 MGRN1 MKRN3 MVB12A NR3C1 PDCD6IP PDLIM7 PPFIBP2 RAD18 RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCNN1A SNF8 SYCE1 TAX1BP1 THRB TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM74 UBA52 UBAP1 USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D	8 interactors: APP EGFR HGS NEDD4 NEDD4L TSG101 WWP2 YAP1
Entrez ID		7251	10067
HPRD ID		03229	06074
Ensembl ID		ENSG00000074319	ENSG00000116521
Uniprot IDs		Q99816	O14828
PDB IDs		1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE
Enriched GO Terms of Interacting Partners?		Virion Assembly Viral Protein Processing Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosomal Transport Establishment Of Protein Localization Intracellular Transport Of Virus Viral Process Protein Transport Protein Localization Protein Catabolic Process Intracellular Transport Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Establishment Of Localization In Cell Viral Life Cycle Protein Ubiquitination Apoptotic Process Cellular Localization Protein Modification By Small Protein Conjugation Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Cell Death Enzyme Linked Receptor Protein Signaling Pathway Modification-dependent Protein Catabolic Process Death Protein Polyubiquitination Cellular Macromolecule Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Organization Apoptotic Signaling Pathway Transport Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Regulation Of Protein Metabolic Process Vacuolar Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Apoptotic Process Protein Processing Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Regulation Of Cell Death Response To Lipid Signal Transduction By P53 Class Mediator	Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transport Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Gene Expression Regulation Of Protein Catabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Sodium Ion Transport Regulation Of Transcription From RNA Polymerase II Promoter Protein Targeting To Lysosome Regulation Of Cellular Localization Response To Radiation Protein Localization To Lysosome Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transmembrane Transporter Activity Negative Regulation Of RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Signaling Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Polyubiquitination Cellular Protein Catabolic Process Protein Targeting To Vacuole Viral Life Cycle Negative Regulation Of Biosynthetic Process Protein Catabolic Process Establishment Of Protein Localization To Vacuole Regulation Of Transcription, DNA-templated Skin Development Protein K63-linked Ubiquitination Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Signal Transduction Epidermis Development Negative Regulation Of Transporter Activity Protein Monoubiquitination Regulation Of Membrane Potential Lysosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle	associate associates carrier compartments coordinately depletions endosomal endosomes escrt escrts hect immunoelectron ligases localizes lysines motifs multimonoubiquitylated multivesicular mvbs prelysosomal psap py recycling sorting sustain tsg101 ubiquitylatable ubiquitylation unless
Tagcloud (Difference) ?		000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle	associate associates carrier compartments coordinately depletions endosomal endosomes escrt escrts hect immunoelectron ligases localizes lysines motifs multimonoubiquitylated multivesicular mvbs prelysosomal psap py recycling sorting sustain ubiquitylatable ubiquitylation unless
Tagcloud (Intersection) ?		tsg101