LSM1 and BEX5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LSM1	BEX5
Description		LSM1 homolog, mRNA degradation associated	brain expressed X-linked 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Lsm1-7-Pat1 Complex Ribonucleoprotein Complex	Cytoplasm
	Molecular Function	RNA Binding MRNA Binding Protein Binding	Signaling Receptor Binding Protein Binding Metal Ion Binding
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA RNA Splicing, Via Transesterification Reactions Nuclear-transcribed MRNA Catabolic Process MRNA Processing RNA Splicing Stem Cell Population Maintenance Neuron Differentiation Negative Regulation Of Neuron Differentiation Histone MRNA Catabolic Process	Signal Transduction
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 22037555 28991256 29483656)
Interacting Genes		32 interacting genes: AGR2 AGR3 BEX5 CLIC1 DAPL1 EXOSC6 EXOSC8 GLUD1 GRHPR GSTA4 HSP90AA1 LSM2 LSM3 LSM5 LSM6 LSM7 MCCD1 MPDU1 N4BP1 NARS1 NDUFAF3 PSMB5 PSMB8 PTPRC RRP1B SMN1 TCL1B TFCP2 TMEM214 UPF2 UXT VPS11	15 interacting genes: BFSP2 COPS7B CRK EMILIN1 FARS2 FOXD4L3 GNG13 GOLGA8F ING3 LSM1 MAGEA8 MORF4L1 MORF4L2 NDUFAB1 PACRGL
Entrez ID		27257	340542
HPRD ID		06281	18484
Ensembl ID		ENSG00000175324	ENSG00000184515
Uniprot IDs		A0A0S2Z590 O15116	Q5H9J7
PDB IDs
Enriched GO Terms of Interacting Partners?		Lsm2-8 Complex U6 SnRNP Lsm1-7-Pat1 Complex MRNA Catabolic Process MRNA Metabolic Process U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome RNA Catabolic Process RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Catabolic Process RNA Splicing RNA Metabolic Process RNA Binding MRNA Processing Macromolecule Catabolic Process Spliceosomal Complex RNA Processing Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process Nucleic Acid Metabolic Process U4 SnRNA 3'-end Processing Threonine-type Endopeptidase Activity Dystroglycan Binding Nucleolar Exosome (RNase Complex) Catabolic Process Proteasome Core Complex, Beta-subunit Complex Nuclear MRNA Surveillance U6 SnRNA Binding Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Macromolecule Metabolic Process Precatalytic Spliceosome Catalytic Step 2 Spliceosome Proteasome Core Complex Nucleobase-containing Compound Metabolic Process RRNA Processing Ribonucleoprotein Complex SnRNA 3'-end Processing P-body RRNA Metabolic Process Positive Regulation Of Isotype Switching CTP Binding DATP Binding Protein Folding Chaperone Complex Plasma Membrane Raft Distribution Hydroxypyruvate Reductase [NAD(P)H] Activity	NuA4 Histone Acetyltransferase Complex Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Recombination Positive Regulation Of Double-strand Break Repair Nucleosome Regulation Of DNA Recombination Positive Regulation Of DNA Repair Regulation Of Double-strand Break Repair
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