LSM1 and LSM2

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (in vitro, two hybrid)

		LSM1	LSM2
Gene Name		LSM1, U6 small nuclear RNA associated	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Cytoplasm Cytosol	Nucleoplasm Cytosol Catalytic Step 2 Spliceosome
	Molecular Function	RNA Cap Binding Protein Binding Poly(A) RNA Binding	Protein Binding U6 SnRNA Binding Ral GTPase Binding Protein Kinase Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Histone MRNA Catabolic Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways		mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		Schizophrenia ( 22037555)
Protein-Protein Interactions		25 interactors: CLIC1 EXOSC6 EXOSC8 GLUD1 GRHPR HSP90AA1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MPDU1 N4BP1 NARS NDUFAF3 PSMB5 PSMB8 PTPRC RRP1B SMN1 TMEM214 UPF2 UXT VPS11	31 interactors: AES BANP C14orf1 CLNS1A CRMP1 DDX20 DNAJA1 EXOSC10 GBP2 KRT13 LNX1 LSM1 LSM3 LSM5 LSM6 LSM7 LSM8 MAGEA6 MEOX2 PRCC RALA REL RSRC1 SF3B2 SMN1 SNRPB SNRPD2 SNRPE TRIM54 ZBTB16 ZNF408
Entrez ID		27257	57819
HPRD ID		06281	06282
Ensembl ID		ENSG00000175324	ENSG00000204392
Uniprot IDs		O15116	Q9Y333
PDB IDs
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process RNA Splicing Catabolic Process MRNA Processing Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Processing Gene Expression RNA Metabolic Process NcRNA Metabolic Process RRNA Processing RRNA Metabolic Process Ribonucleoprotein Complex Biogenesis Ribosome Biogenesis MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Metabolic Process Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Immunoglobulin Production Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Mitotic Cell Cycle Phase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity	RNA Splicing MRNA Metabolic Process MRNA Processing RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Splicing, Via Spliceosome RNA Metabolic Process Spliceosomal SnRNP Assembly Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Histone MRNA Metabolic Process Nitrogen Compound Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Ribonucleoprotein Complex Assembly RNA Catabolic Process NcRNA Metabolic Process Aromatic Compound Catabolic Process Histone MRNA Catabolic Process Spliceosomal Complex Assembly Cellular Metabolic Process Cellular Macromolecule Catabolic Process Cellular Macromolecular Complex Assembly Metabolic Process Termination Of RNA Polymerase II Transcription Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Catabolic Process DNA-templated Transcription, Termination Transcription From RNA Polymerase II Promoter MRNA 3'-end Processing Membrane Raft Localization Positive Regulation Of Anoikis Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Embryonic Pattern Specification Cellular Process Positive Regulation Of Apoptotic Process Positive Regulation Of NK T Cell Differentiation Positive Regulation Of Programmed Cell Death Transcription, DNA-templated Positive Regulation Of Cell Death Male Germ-line Stem Cell Asymmetric Division Somite Specification
Tagcloud ?		activators cerevisiae codons dcp1 dcp2 deadenylation decapping decay defines dhh1 edc1 edc2 edc3 hybrid nmd nonsense overlapping pat1 premature proper recruit saccharomyces stimulators termed termination transcripts upf1 upf2 upf3	angles arrange assemble building heptameric heteroheptameric hexameric incorporate lsm1 lsm23 lsm5 lsm57 lsm6 lsm657 lsm7 monomers nonetheless plastic pockets preferences pull ring sme smf smg solved spliceosomal
Tagcloud (Difference) ?		activators cerevisiae codons dcp1 dcp2 deadenylation decapping decay defines dhh1 edc1 edc2 edc3 hybrid nmd nonsense overlapping pat1 premature proper recruit saccharomyces stimulators termed termination transcripts upf1 upf2 upf3	angles arrange assemble building heptameric heteroheptameric hexameric incorporate lsm23 lsm5 lsm57 lsm6 lsm657 lsm7 monomers nonetheless plastic pockets preferences pull ring sme smf smg solved spliceosomal
Tagcloud (Intersection) ?		lsm1