LSM1 and RRP1B

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LSM1	RRP1B
Description		LSM1 homolog, mRNA degradation associated	ribosomal RNA processing 1B
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Lsm1-7-Pat1 Complex Ribonucleoprotein Complex	Euchromatin Heterochromatin Granular Component Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Preribosome, Small Subunit Precursor
	Molecular Function	RNA Binding MRNA Binding Protein Binding	Transcription Coactivator Activity RNA Binding Protein Binding
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA RNA Splicing, Via Transesterification Reactions Nuclear-transcribed MRNA Catabolic Process MRNA Processing RNA Splicing Stem Cell Population Maintenance Neuron Differentiation Negative Regulation Of Neuron Differentiation Histone MRNA Catabolic Process	RRNA Processing MRNA Processing Apoptotic Process RNA Splicing Negative Regulation Of GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of RNA Splicing Host-mediated Activation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Virus
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 22037555 28991256 29483656)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27618447 28135244) Mean corpuscular hemoglobin ( 27863252) Refractive error ( 32231278) Systolic blood pressure ( 27618447)
Interacting Genes		32 interacting genes: AGR2 AGR3 BEX5 CLIC1 DAPL1 EXOSC6 EXOSC8 GLUD1 GRHPR GSTA4 HSP90AA1 LSM2 LSM3 LSM5 LSM6 LSM7 MCCD1 MPDU1 N4BP1 NARS1 NDUFAF3 PSMB5 PSMB8 PTPRC RRP1B SMN1 TCL1B TFCP2 TMEM214 UPF2 UXT VPS11	6 interacting genes: CSNK2A1 LSM1 OGT PPP1CA PPP1CC SRPK2
Entrez ID		27257	23076
HPRD ID		06281	10009
Ensembl ID		ENSG00000175324	ENSG00000160208
Uniprot IDs		A0A0S2Z590 O15116	Q14684
PDB IDs			7T0Y
Enriched GO Terms of Interacting Partners?		Lsm2-8 Complex U6 SnRNP Lsm1-7-Pat1 Complex MRNA Catabolic Process MRNA Metabolic Process U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome RNA Catabolic Process RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Catabolic Process RNA Splicing RNA Metabolic Process RNA Binding MRNA Processing Macromolecule Catabolic Process Spliceosomal Complex RNA Processing Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process Nucleic Acid Metabolic Process U4 SnRNA 3'-end Processing Threonine-type Endopeptidase Activity Dystroglycan Binding Nucleolar Exosome (RNase Complex) Catabolic Process Proteasome Core Complex, Beta-subunit Complex Nuclear MRNA Surveillance U6 SnRNA Binding Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Macromolecule Metabolic Process Precatalytic Spliceosome Catalytic Step 2 Spliceosome Proteasome Core Complex Nucleobase-containing Compound Metabolic Process RRNA Processing Ribonucleoprotein Complex SnRNA 3'-end Processing P-body RRNA Metabolic Process Positive Regulation Of Isotype Switching CTP Binding DATP Binding Protein Folding Chaperone Complex Plasma Membrane Raft Distribution Hydroxypyruvate Reductase [NAD(P)H] Activity	Rhythmic Process Circadian Regulation Of Gene Expression PTW/PP1 Phosphatase Complex Regulation Of Translational Initiation Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Methylguanosine-cap Decapping Circadian Rhythm RNA Decapping Sin3-type Complex Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock Presynapse Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Double-strand Break Repair Via Nonhomologous End Joining Protein Modification Process Glycogen Metabolic Process Regulation Of Carbohydrate Catabolic Process Protein Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Phosphatase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Carbohydrate Metabolic Process Regulation Of Translation Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Localization To Vacuole Macromolecule Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Glucose Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Circadian Rhythm Protein O-linked Glycosylation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Protein O-acetylglucosaminyltransferase Activity MRNA Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Positive Regulation Of Termination Of DNA-templated Transcription Dephosphorylation
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