LSM1 and N4BP1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		LSM1	N4BP1
Description		LSM1 homolog, mRNA degradation associated	NEDD4 binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Lsm1-7-Pat1 Complex Ribonucleoprotein Complex	Nucleus Nucleolus Cytoplasm Cytosol PML Body
	Molecular Function	RNA Binding MRNA Binding Protein Binding	RNA Binding MRNA Binding Nuclease Activity RNA Nuclease Activity Protein Binding Hydrolase Activity Ubiquitin Binding
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA RNA Splicing, Via Transesterification Reactions Nuclear-transcribed MRNA Catabolic Process MRNA Processing RNA Splicing Stem Cell Population Maintenance Neuron Differentiation Negative Regulation Of Neuron Differentiation Histone MRNA Catabolic Process	Negative Regulation Of Cytokine Production Immune System Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of Innate Immune Response
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease	Regulation of NF-kappa B signaling
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 22037555 28991256 29483656)	Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 33031748) Social autistic-like traits ( 24133439) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		32 interacting genes: AGR2 AGR3 BEX5 CLIC1 DAPL1 EXOSC6 EXOSC8 GLUD1 GRHPR GSTA4 HSP90AA1 LSM2 LSM3 LSM5 LSM6 LSM7 MCCD1 MPDU1 N4BP1 NARS1 NDUFAF3 PSMB5 PSMB8 PTPRC RRP1B SMN1 TCL1B TFCP2 TMEM214 UPF2 UXT VPS11	8 interacting genes: AZI2 CDK6 ITCH LITAF LSM1 MID1 NEDD8 UBC
Entrez ID		27257	9683
HPRD ID		06281
Ensembl ID		ENSG00000175324	ENSG00000102921
Uniprot IDs		A0A0S2Z590 O15116	O75113
PDB IDs			6Q3V
Enriched GO Terms of Interacting Partners?		Lsm2-8 Complex U6 SnRNP Lsm1-7-Pat1 Complex MRNA Catabolic Process MRNA Metabolic Process U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome RNA Catabolic Process RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Catabolic Process RNA Splicing RNA Metabolic Process RNA Binding MRNA Processing Macromolecule Catabolic Process Spliceosomal Complex RNA Processing Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process Nucleic Acid Metabolic Process U4 SnRNA 3'-end Processing Threonine-type Endopeptidase Activity Dystroglycan Binding Nucleolar Exosome (RNase Complex) Catabolic Process Proteasome Core Complex, Beta-subunit Complex Nuclear MRNA Surveillance U6 SnRNA Binding Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Macromolecule Metabolic Process Precatalytic Spliceosome Catalytic Step 2 Spliceosome Proteasome Core Complex Nucleobase-containing Compound Metabolic Process RRNA Processing Ribonucleoprotein Complex SnRNA 3'-end Processing P-body RRNA Metabolic Process Positive Regulation Of Isotype Switching CTP Binding DATP Binding Protein Folding Chaperone Complex Plasma Membrane Raft Distribution Hydroxypyruvate Reductase [NAD(P)H] Activity	Regulation Of Hematopoietic Stem Cell Differentiation Protein Tag Activity Regulation Of Hematopoietic Progenitor Cell Differentiation T Cell Activation Ubiquitin Protein Ligase Binding Endosome Membrane Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Stem Cell Differentiation Response To Virus Cytoplasm Cyclin D3-CDK6 Complex Lymphocyte Activation Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex FBXO Family Protein Binding Macromolecule Catabolic Process Cytoplasmic Side Of Late Endosome Membrane Negative Regulation Of Canonical NF-kappaB Signal Transduction Gliogenesis Negative Regulation Of Monocyte Differentiation Leukocyte Activation Cell Dedifferentiation Cell Activation Response To External Biotic Stimulus Cellular Response To Camptothecin Protein Ubiquitination Modification-dependent Protein Catabolic Process Cytoplasmic Side Of Early Endosome Membrane Lsm1-7-Pat1 Complex Dendritic Cell Proliferation Leukocyte Proliferation Mononuclear Cell Proliferation Positive Regulation Of T Cell Anergy CXCL12-activated CXCR4 Signaling Pathway T Cell Tolerance Induction T Cell Anergy Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation C-X-C Chemokine Receptor CXCR4 Signaling Pathway Early Endosome Membrane Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Regulation Of T Cell Anergy Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Receptor Catabolic Process CD4-positive, Alpha-beta T Cell Proliferation Arrestin Family Protein Binding Positive Regulation Of T Cell Tolerance Induction Lateral Ventricle Development Type B Pancreatic Cell Development Post-translational Protein Modification
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?