LSM1 and N4BP1

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		LSM1	N4BP1
Gene Name		LSM1, U6 small nuclear RNA associated	NEDD4 binding protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Cytoplasm Cytosol	Nucleolus PML Body
	Molecular Function	RNA Cap Binding Protein Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Histone MRNA Catabolic Process	Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV
Pathways		mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		Schizophrenia ( 22037555)
Protein-Protein Interactions		25 interactors: CLIC1 EXOSC6 EXOSC8 GLUD1 GRHPR HSP90AA1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MPDU1 N4BP1 NARS NDUFAF3 PSMB5 PSMB8 PTPRC RRP1B SMN1 TMEM214 UPF2 UXT VPS11	5 interactors: AZI2 CDK6 ITCH LSM1 UBC
Entrez ID		27257	9683
HPRD ID		06281
Ensembl ID		ENSG00000175324	ENSG00000102921
Uniprot IDs		O15116	O75113
PDB IDs
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process RNA Splicing Catabolic Process MRNA Processing Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Processing Gene Expression RNA Metabolic Process NcRNA Metabolic Process RRNA Processing RRNA Metabolic Process Ribonucleoprotein Complex Biogenesis Ribosome Biogenesis MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Metabolic Process Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Immunoglobulin Production Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Mitotic Cell Cycle Phase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity	Notch Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Tumor Necrosis Factor Production Cell Dedifferentiation Mitotic Cell Cycle Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune System Process Activation Of Innate Immune Response G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Protein Polyubiquitination Positive Regulation Of Innate Immune Response Interferon-alpha Production Viral Life Cycle Intracellular Receptor Signaling Pathway Negative Regulation Of Cytokine Production Interleukin-6 Production Positive Regulation Of Protein Catabolic Process Dendritic Cell Proliferation Protein K29-linked Ubiquitination Regulation Of Innate Immune Response Regulation Of Protein Deubiquitination Positive Regulation Of T Cell Anergy Mitotic Cell Cycle Phase Transition Response To Virus Cell Cycle Phase Transition T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Regulation Of Immune System Process Cell Cycle Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Leukocyte Cell-cell Adhesion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Homotypic Cell-cell Adhesion Leukocyte Differentiation Negative Regulation Of Alpha-beta T Cell Proliferation Regulation Of T Cell Anergy Histone MRNA Catabolic Process Negative Regulation Of Cellular Senescence Viral Protein Processing Negative Regulation Of Immune System Process Positive Regulation Of T Cell Tolerance Induction Regulation Of Protein Catabolic Process
Tagcloud ?		activators cerevisiae codons dcp1 dcp2 deadenylation decapping decay defines dhh1 edc1 edc2 edc3 hybrid nmd nonsense overlapping pat1 premature proper recruit saccharomyces stimulators termed termination transcripts upf1 upf2 upf3	carp cdna cik cloned close ctenopharyngodon e3 encoded frame gcrv gill grass head homology idella interacting kh latipes ligase limit nedd4 nyn orf oryzias reading reovirus spleen
Tagcloud (Difference) ?		activators cerevisiae codons dcp1 dcp2 deadenylation decapping decay defines dhh1 edc1 edc2 edc3 hybrid nmd nonsense overlapping pat1 premature proper recruit saccharomyces stimulators termed termination transcripts upf1 upf2 upf3	carp cdna cik cloned close ctenopharyngodon e3 encoded frame gcrv gill grass head homology idella interacting kh latipes ligase limit nedd4 nyn orf oryzias reading reovirus spleen
Tagcloud (Intersection) ?