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LSM1 and EXOSC6
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
HPRD
(two hybrid)
LSM1
EXOSC6
Gene Name
LSM1, U6 small nuclear RNA associated
exosome component 6
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasmic MRNA Processing Body
Nucleus
Cytoplasm
Cytosol
Exosome (RNase Complex)
Nucleolus
Cytosol
Molecular Function
RNA Cap Binding
Protein Binding
Poly(A) RNA Binding
Exoribonuclease Activity
Poly(A) RNA Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
RNA Splicing, Via Transesterification Reactions
MRNA Processing
RNA Splicing
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Histone MRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
DNA Deamination
Isotype Switching
Pathways
mRNA decay by 5' to 3' exoribonuclease
Deadenylation-dependent mRNA decay
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Schizophrenia (
22037555
)
Protein-Protein Interactions
25 interactors:
CLIC1
EXOSC6
EXOSC8
GLUD1
GRHPR
HSP90AA1
LSM2
LSM3
LSM4
LSM5
LSM6
LSM7
MPDU1
N4BP1
NARS
NDUFAF3
PSMB5
PSMB8
PTPRC
RRP1B
SMN1
TMEM214
UPF2
UXT
VPS11
35 interactors:
C1QBP
CHPF
DCP1B
DIS3
DNAJC30
EIF3I
ESRRA
EXOSC1
EXOSC10
EXOSC2
EXOSC4
EXOSC5
EXOSC7
EXOSC8
EXOSC9
GSE1
LSM1
LSM7
LSM8
MAN2C1
MIF4GD
MOCS3
MPP6
MRPL4
MRPS18B
NDUFA13
NUDT21
PSMB1
RAB3GAP2
SKIV2L2
SRSF3
TUFM
UPF2
XRN1
ZFP36
Entrez ID
27257
118460
HPRD ID
06281
12107
Ensembl ID
ENSG00000175324
ENSG00000223496
Uniprot IDs
O15116
Q5RKV6
PDB IDs
2NN6
Enriched GO Terms of Interacting Partners
?
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
RNA Catabolic Process
MRNA Metabolic Process
Cellular Macromolecule Catabolic Process
Aromatic Compound Catabolic Process
RNA Splicing
Catabolic Process
MRNA Processing
Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
RNA Processing
Gene Expression
RNA Metabolic Process
NcRNA Metabolic Process
RRNA Processing
RRNA Metabolic Process
Ribonucleoprotein Complex Biogenesis
Ribosome Biogenesis
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Cellular Metabolic Process
Cell Cycle Phase Transition
Negative Regulation Of Protein Ubiquitination
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Protein Ubiquitination
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Immunoglobulin Production
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Immunoglobulin Biosynthetic Process
Positive Regulation Of Hematopoietic Stem Cell Migration
Mitotic Cell Cycle Phase Transition
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Transferase Activity
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Ligase Activity
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
MRNA Metabolic Process
MRNA Catabolic Process
RNA Catabolic Process
RRNA Metabolic Process
Aromatic Compound Catabolic Process
Ribosome Biogenesis
RRNA Processing
Ribonucleoprotein Complex Biogenesis
Gene Expression
Cellular Macromolecule Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
NcRNA Metabolic Process
Nuclear MRNA Surveillance
RNA Metabolic Process
RNA Surveillance
RRNA Catabolic Process
Maturation Of 5.8S RRNA
RNA Phosphodiester Bond Hydrolysis
Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Catabolic Process
Nucleobase-containing Compound Metabolic Process
Histone MRNA Catabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
RNA Processing
Cellular Metabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
Histone MRNA Metabolic Process
MRNA Processing
RNA Splicing
Metabolic Process
RNA 3'-end Processing
RNA Splicing, Via Transesterification Reactions
RNA Localization
DNA Deamination
Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
Intracellular MRNA Localization
Mitochondrial Translational Elongation
MRNA 3'-end Processing
Mitochondrion Organization
Mitochondrial Translation
MRNA Splicing, Via Spliceosome
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Tagcloud
?
activators
cerevisiae
codons
dcp1
dcp2
deadenylation
decapping
decay
defines
dhh1
edc1
edc2
edc3
hybrid
nmd
nonsense
overlapping
pat1
premature
proper
recruit
saccharomyces
stimulators
termed
termination
transcripts
upf1
upf2
upf3
Tagcloud (Difference)
?
activators
cerevisiae
codons
dcp1
dcp2
deadenylation
decapping
decay
defines
dhh1
edc1
edc2
edc3
hybrid
nmd
nonsense
overlapping
pat1
premature
proper
recruit
saccharomyces
stimulators
termed
termination
transcripts
upf1
upf2
upf3
Tagcloud (Intersection)
?