PRKAG3 and PRKAB1

Number of citations of the paper that reports this interaction (PMID 10698692)
99

Data Source:
BioGRID (two hybrid)

		PRKAG3	PRKAB1
Gene Name		protein kinase, AMP-activated, gamma 3 non-catalytic subunit	protein kinase, AMP-activated, beta 1 non-catalytic subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytosol AMP-activated Protein Kinase Complex	Nucleus Cytosol AMP-activated Protein Kinase Complex
	Molecular Function	AMP-activated Protein Kinase Activity ATP Binding Protein Kinase Binding	Protein Kinase Activity AMP-activated Protein Kinase Activity Protein Binding Protein Kinase Binding
	Biological Process	Glycogen Biosynthetic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Organelle Organization Mitochondrion Organization Cell Cycle Arrest Insulin Receptor Signaling Pathway Glucose Transport Intracellular Signal Transduction Membrane Organization	Protein Phosphorylation Fatty Acid Biosynthetic Process Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Protein Kinase Activity Protein Heterooligomerization Membrane Organization
Pathways		Organelle biogenesis and maintenance Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling Translocation of GLUT4 to the plasma membrane IRS-related events mTOR signalling IGF1R signaling cascade Mitochondrial biogenesis IRS-related events triggered by IGF1R Activation of PPARGC1A (PGC-1alpha) by phosphorylation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	Organelle biogenesis and maintenance Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling Translocation of GLUT4 to the plasma membrane IRS-related events mTOR signalling IGF1R signaling cascade Mitochondrial biogenesis IRS-related events triggered by IGF1R Activation of PPARGC1A (PGC-1alpha) by phosphorylation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs			Adenosine monophosphate Metformin
Diseases
GWAS
Protein-Protein Interactions		7 interactors: BRCA1 CRYAB LMCD1 NGRN PRKAA1 PRKAB1 PRKAB2	13 interactors: ACACA AGL APP F10 GRB2 MAP3K7 MAPK6 NDUFA7 PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3
Entrez ID		53632	5564
HPRD ID		16085	04116
Ensembl ID		ENSG00000115592	ENSG00000111725
Uniprot IDs		B4DUK8 Q9UGI9	Q9Y478
PDB IDs
Enriched GO Terms of Interacting Partners?		Fatty Acid Biosynthetic Process Fatty Acid Metabolic Process Response To Hormone Negative Regulation Of Cell Cycle Cellular Response To Organonitrogen Compound Regulation Of Lipid Biosynthetic Process Response To Ionizing Radiation Cell Cycle Arrest Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Insulin Stimulus Regulation Of Fatty Acid Biosynthetic Process Response To Organonitrogen Compound Negative Regulation Of Reactive Oxygen Species Metabolic Process Response To Insulin Regulation Of Lipid Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Regulation Of Cell Cycle Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Lipid Metabolic Process Response To Gamma Radiation Carboxylic Acid Metabolic Process Cell Cycle Process Regulation Of Protein Metabolic Process Organic Acid Metabolic Process Protein Oligomerization Response To Radiation Negative Regulation Of Lipid Metabolic Process Response To Peptide Hormone Response To Organic Substance Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Response To Peptide Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Cell Cycle Cellular Response To Hormone Stimulus Response To Hydrogen Peroxide Positive Regulation Of Histone H3-K9 Acetylation Protein Heterooligomerization Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation	Fatty Acid Biosynthetic Process Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Regulation Of Glycolytic Process Response To Insulin Energy Derivation By Oxidation Of Organic Compounds Energy Reserve Metabolic Process Cellular Response To Peptide Hormone Stimulus Carnitine Shuttle Fatty Acid Metabolic Process Cellular Response To Peptide Cell Cycle Arrest Carnitine Transmembrane Transport Carnitine Transport Generation Of Precursor Metabolites And Energy Phosphorylation Regulation Of Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Protein Phosphorylation Response To Peptide Quaternary Ammonium Group Transport Phosphate-containing Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Hormone Stimulus Small Molecule Metabolic Process Sterol Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Carbohydrate Metabolic Process Long-chain Fatty Acid Transport Ammonium Transmembrane Transport Sterol Biosynthetic Process Lipid Metabolic Process Response To Organonitrogen Compound Negative Regulation Of Cell Cycle Glycogen Metabolic Process Fatty Acid Transport Regulation Of Cell Cycle Oxidation-reduction Process Cellular Lipid Metabolic Process Cellular Protein Modification Process Ammonium Transport Steroid Metabolic Process Carboxylic Acid Metabolic Process Polysaccharide Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		accompanying adjust alga0035896 asga0009814 asga0070634 beadchip bonferroni color consumers corresponds deregressed finnish ham illumina lightness loin meat megabases polygenic porcinesnp60 qlt rcn1 redness relatedness smallest snp substitutions traits yorkshire	adipor1 alter amp bdkrb2 changed differential discordant epigenome exercise fh hoxc6 mapk1 mef2a methylation modifies monozygotic muscle myo18b ndufc2 pairs predispose retinol runx1 skeletal t2d thada trib1 twin twins
Tagcloud (Difference) ?		accompanying adjust alga0035896 asga0009814 asga0070634 beadchip bonferroni color consumers corresponds deregressed finnish ham illumina lightness loin meat megabases polygenic porcinesnp60 qlt rcn1 redness relatedness smallest snp substitutions traits yorkshire	adipor1 alter amp bdkrb2 changed differential discordant epigenome exercise fh hoxc6 mapk1 mef2a methylation modifies monozygotic muscle myo18b ndufc2 pairs predispose retinol runx1 skeletal t2d thada trib1 twin twins
Tagcloud (Intersection) ?