PRKAG3 and CRYAB

Number of citations of the paper that reports this interaction (PubMedID 19616115)
0

Data Source:
BioGRID (two hybrid)

		PRKAG3	CRYAB
Description		protein kinase AMP-activated non-catalytic subunit gamma 3	crystallin alpha B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Cell Surface Z Disc Axon M Band I Band Actin Filament Bundle Protein-containing Complex Dendritic Spine Perikaryon Contractile Muscle Fiber Extracellular Exosome Synaptic Membrane Cardiac Myofibril
	Molecular Function	Nucleotide Binding AMP-activated Protein Kinase Activity Protein Binding ATP Binding AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding	Amyloid-beta Binding Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Cytoskeletal Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Regulation Of Glycolytic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Cellular Response To Nutrient Levels Intracellular Signal Transduction Cellular Response To Glucose Starvation Regulation Of Carbon Utilization Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Gluconeogenesis Regulation Of Cell Cycle	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Response To Heat Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Protein Stabilization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	HSF1-dependent transactivation
Drugs		Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases			Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol ( 25961943) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 33339817) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Triglyceride levels ( 32203549 33339817)	Birth weight ( 31043758) Hip circumference adjusted for BMI ( 34021172) PR interval ( 32439900)
Interacting Genes		6 interacting genes: BRCA1 CRYAB KRTAP19-5 LMCD1 NGRN PRKAA1	57 interacting genes: - ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CAPN3 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CRYGS CS DDX20 DES EPB41 FCGR2A FGF2 GFAP GORASP2 HBA1 HSPB1 HSPB2 HSPB6 HSPB8 INS KRTAP19-5 KRTAP6-1 KRTAP8-1 LALBA LBH MDH2 MIP MRPL11 NGF PRKAG3 PRNP PSMA3 RBM11 SCN5A SLC13A1 SNCA SOD1 SQSTM1 TIAM1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA
Entrez ID		53632	1410
HPRD ID		16085	00428
Ensembl ID		ENSG00000115592	ENSG00000109846
Uniprot IDs		Q9UGI9	A0A024R3B9 P02511 V9HW27
PDB IDs			2KLR 2N0K 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3J07 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS 4M5S 4M5T 5VVV 6BP9 7ROJ 9BEE
Enriched GO Terms of Interacting Partners?		Response To Ionizing Radiation Protein K6-linked Ubiquitination Negative Regulation Of Reactive Oxygen Species Metabolic Process Response To Gamma Radiation Negative Regulation Of Lipid Biosynthetic Process Response To Radiation Cellular Response To Ionizing Radiation Negative Regulation Of Glucosylceramide Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Fatty Acid Biosynthetic Process Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of Lipid Metabolic Process BRCA1-BARD1 Complex Response To Hydrogen Peroxide Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Reactive Oxygen Species Metabolic Process BRCA1-B Complex Negative Regulation Of Cell Growth Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Cellular Response To Radiation Protein-containing Complex Response To Indole-3-methanol Regulation Of Lipid Biosynthetic Process Response To Reactive Oxygen Species Response To Temperature Stimulus Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Tubulin Deacetylation Cold Acclimation Positive Regulation Of Mitochondrial Transcription Negative Regulation Of Sphingolipid Biosynthetic Process CAMP-dependent Protein Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Positive Regulation Of Translation Protein Localization To Lipid Droplet CAMKK-AMPK Signaling Cascade Mitochondrial Ribosome Assembly Negative Regulation Of Centriole Replication Negative Regulation Of Growth Negative Regulation Of Apoptotic Process Cardiac Myofibril Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Negative Regulation Of Programmed Cell Death BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Protein Stabilization	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Identical Protein Binding System Process Protein Refolding Regulation Of Transport Response To Metal Ion Regulation Of Autophagy Response To Heat Sensory Perception Regulation Of Multicellular Organismal Process Nervous System Process Apoptotic Process Programmed Cell Death Cellular Response To Metal Ion Positive Regulation Of Growth Cell Death Response To Oxidative Stress Visual Perception Sensory Perception Of Light Stimulus Regulation Of Growth Response To Copper Ion Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Z Disc Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Cellular Response To Stress Response To Unfolded Protein Positive Regulation Of Apoptotic Process Response To Temperature Stimulus Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Long-term Synaptic Potentiation Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Programmed Cell Death Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Endocytosis Cytosol Positive Regulation Of Transport Positive Regulation Of Protein Localization Response To Reactive Oxygen Species Positive Regulation Of Cell Growth Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Ovarian Follicle Development
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