PRKAG3 and CRYAB

Number of citations of the paper that reports this interaction (PMID 19616115)
4

Data Source:
BioGRID (two hybrid)

		PRKAG3	CRYAB
Gene Name		protein kinase, AMP-activated, gamma 3 non-catalytic subunit	crystallin, alpha B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytosol AMP-activated Protein Kinase Complex	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Cell Surface Microtubule Cytoskeleton Z Disc Actin Filament Bundle Extracellular Vesicular Exosome
	Molecular Function	AMP-activated Protein Kinase Activity ATP Binding Protein Kinase Binding	Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Unfolded Protein Binding
	Biological Process	Glycogen Biosynthetic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Organelle Organization Mitochondrion Organization Cell Cycle Arrest Insulin Receptor Signaling Pathway Glucose Transport Intracellular Signal Transduction Membrane Organization	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Aging Regulation Of Cell Death Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Response To Estradiol Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Homooligomerization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Organelle biogenesis and maintenance Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling Translocation of GLUT4 to the plasma membrane IRS-related events mTOR signalling IGF1R signaling cascade Mitochondrial biogenesis IRS-related events triggered by IGF1R Activation of PPARGC1A (PGC-1alpha) by phosphorylation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: BRCA1 CRYAB LMCD1 NGRN PRKAA1 PRKAB1 PRKAB2	44 interactors: ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CS DDX20 DES EPB41 FCGR2A FGF2 GFAP HBA1 HSPB1 HSPB2 HSPB8 INS KRTAP19-5 KRTAP8-1 LALBA MDH2 MIP MRPL11 NGF PRKAG3 PSMA3 SNCA SOD1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA
Entrez ID		53632	1410
HPRD ID		16085	00428
Ensembl ID		ENSG00000115592	ENSG00000109846
Uniprot IDs		B4DUK8 Q9UGI9	P02511
PDB IDs			2KLR 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS
Enriched GO Terms of Interacting Partners?		Fatty Acid Biosynthetic Process Fatty Acid Metabolic Process Response To Hormone Negative Regulation Of Cell Cycle Cellular Response To Organonitrogen Compound Regulation Of Lipid Biosynthetic Process Response To Ionizing Radiation Cell Cycle Arrest Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Insulin Stimulus Regulation Of Fatty Acid Biosynthetic Process Response To Organonitrogen Compound Negative Regulation Of Reactive Oxygen Species Metabolic Process Response To Insulin Regulation Of Lipid Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Regulation Of Cell Cycle Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Lipid Metabolic Process Response To Gamma Radiation Carboxylic Acid Metabolic Process Cell Cycle Process Regulation Of Protein Metabolic Process Organic Acid Metabolic Process Protein Oligomerization Response To Radiation Negative Regulation Of Lipid Metabolic Process Response To Peptide Hormone Response To Organic Substance Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Response To Peptide Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Cell Cycle Cellular Response To Hormone Stimulus Response To Hydrogen Peroxide Positive Regulation Of Histone H3-K9 Acetylation Protein Heterooligomerization Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation	Response To Stress Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To External Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process Visual Perception Sensory Perception Of Light Stimulus Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Regulation Of Lipid Metabolic Process Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cellular Response To Oxidative Stress Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of Growth Response To Wounding Neuron Apoptotic Process Camera-type Eye Development Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Phosphorylation Regulation Of Neuron Apoptotic Process Regulation Of Lipid Biosynthetic Process Organ Development Neuron Death Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Eye Development Programmed Cell Death Sensory Organ Development Response To Oxidative Stress Platelet Degranulation Sensory Perception
Tagcloud ?		accompanying adjust alga0035896 asga0009814 asga0070634 beadchip bonferroni color consumers corresponds deregressed finnish ham illumina lightness loin meat megabases polygenic porcinesnp60 qlt rcn1 redness relatedness smallest snp substitutions traits yorkshire	adaptive aggregated antiapoptotic assisting cardiomyocyte cardiomyocytes chaperons confers correct crystallin elicit emphasizing folding hsp hsps interplay lumen mini misfolded mitigate myocardium myocytes referred stressed stresses undergo unfolded upr worldwide
Tagcloud (Difference) ?		accompanying adjust alga0035896 asga0009814 asga0070634 beadchip bonferroni color consumers corresponds deregressed finnish ham illumina lightness loin meat megabases polygenic porcinesnp60 qlt rcn1 redness relatedness smallest snp substitutions traits yorkshire	adaptive aggregated antiapoptotic assisting cardiomyocyte cardiomyocytes chaperons confers correct crystallin elicit emphasizing folding hsp hsps interplay lumen mini misfolded mitigate myocardium myocytes referred stressed stresses undergo unfolded upr worldwide
Tagcloud (Intersection) ?