KLF15 and SUV39H1

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		KLF15	SUV39H1
Gene Name		Kruppel-like factor 15	suppressor of variegation 3-9 homolog 1 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Chromosome, Centromeric Region Heterochromatin Condensed Nuclear Chromosome Nucleus Nuclear Lamina Nucleoplasm Chromatin Silencing Complex RDNA Heterochromatin
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Protein N-terminus Binding
	Biological Process	Transcription, DNA-templated Glial Cell Differentiation Cardiac Muscle Hypertrophy In Response To Stress Glucose Transport Positive Regulation Of Transcription From RNA Polymerase II Promoter Glomerular Visceral Epithelial Cell Differentiation Cellular Response To Peptide Negative Regulation Of Peptidyl-lysine Acetylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Chromatin Organization Transcription, DNA-templated RRNA Processing Cellular Response To DNA Damage Stimulus Cell Cycle Gene Expression Viral Process Cell Differentiation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Circadian Rhythm Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia
Pathways			Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression SIRT1 negatively regulates rRNA Expression
Drugs
Diseases
GWAS		Metabolite levels ( 23378610)
Protein-Protein Interactions		5 interactors: PRKAB2 SNX13 SUV39H1 TCF21 ZBTB24	123 interactors: ATE1 ATF3 ATP6V1B1 BAHD1 BCL11B C17orf82 C4orf17 C8orf74 CBX1 CBX4 CBX5 CCDC151 CCDC37 CDC23 CDCA4 CDCA7L CEP70 CLK3 CRBN CREBBP CRELD2 DBF4B DCAF8 DNMT1 DNMT3A DNMT3B ELOF1 EP300 ESR1 EZH2 FGD5 FOXR2 FRMD6 FUS FYN GPATCH2L GTF2H2C_2 GTPBP2 H3F3C HDAC1 HDAC2 HDAC3 HDAC5 HDAC9 HIST1H3A HIST2H3A HIST3H3 HOOK2 HOXA1 HOXC4 ID1 ID2 IGFBP4 IL16 ING4 INTS2 KDM1A KLF15 KLHDC4 KLHL20 KRTAP10-7 LDHAL6B LENG8 LHX8 LNX1 LOXL4 LZTS2 MALT1 MBD1 MBD4 MCRS1 MSANTD3 MTF2 MTO1 MYOD1 NR1H2 NR1H3 OPA3 PHF19 PML PNKP PRIM2 PRMT6 PSMC1 RASSF1 RASSF2 RB1 RBBP4 RBBP7 RBL1 RBL2 RRP8 RSPO2 RUNX1 SBF1 SLFN12 SMAD1 SMAD5 SPATA24 SPRED1 SPSB1 SRGAP3 STX11 STX19 TEX35 THRA TMEM11 TNFAIP1 U2AF1 WDFY3 WIZ ZBTB24 ZCCHC17 ZKSCAN5 ZNF165 ZNF436 ZNF451 ZNF557 ZNF581 ZNF649 ZNF670 ZNF829 ZSCAN9
Entrez ID		28999	6839
HPRD ID		07568	02221
Ensembl ID		ENSG00000163884	ENSG00000101945
Uniprot IDs		Q9UIH9	B4DST0 O43463
PDB IDs		2ENT	3MTS
Enriched GO Terms of Interacting Partners?		Bronchiole Development Metanephric Mesenchymal Cell Differentiation Branchiomeric Skeletal Muscle Development Metanephric Glomerular Capillary Formation Histone H3-K9 Dimethylation Carnitine Shuttle Glomerular Capillary Formation Mesenchymal Cell Differentiation Involved In Kidney Development Lung Vasculature Development Histone H3-K9 Trimethylation Metanephric Glomerulus Vasculature Development Carnitine Transmembrane Transport Diaphragm Development Carnitine Transport Peptidyl-lysine Dimethylation Cell Differentiation Involved In Metanephros Development Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Metabolic Process Chromatin Silencing At RDNA Metanephric Glomerulus Development Glomerulus Morphogenesis Metanephric Mesenchyme Development Quaternary Ammonium Group Transport Negative Regulation Of Circadian Rhythm Regulation Of Androgen Receptor Signaling Pathway Histone H3-K9 Methylation Glomerulus Vasculature Development Sex Determination Peptidyl-lysine Trimethylation Embryonic Digestive Tract Morphogenesis Sertoli Cell Differentiation Regulation Of Fatty Acid Biosynthetic Process Biosynthetic Process Chromatin Silencing Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Histone H3-K9 Modification Transcription, DNA-templated Immune System Development Cell Differentiation Involved In Kidney Development Metanephric Nephron Development Long-chain Fatty Acid Transport RNA Biosynthetic Process Ammonium Transmembrane Transport Embryonic Digestive Tract Development Spleen Development Negative Regulation Of Transcription From RNA Polymerase II Promoter	RNA Biosynthetic Process Transcription, DNA-templated Gene Expression Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Chromatin Modification Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Chromosome Organization Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression, Epigenetic Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Organelle Organization Chromatin Silencing Gene Silencing Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation On Cytosine Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Histone Modification Histone H4 Deacetylation Cellular Process Regulation Of Cell Cycle Metabolic Process
Tagcloud ?		adig adipogenesis adipogenic axin bmp2 cebpa cebpb damiana ddit3 dlk ebpalpha fasn favors fgf10 fgf2 foxo1 guarana klf2 lep lpl mate ppargamma2 resveratrol sirt2 srebf1 synergy ucp1 yerba ygd	adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly setdb1 t98g verified
Tagcloud (Difference) ?		adig adipogenesis adipogenic axin bmp2 cebpa cebpb damiana ddit3 dlk ebpalpha fasn favors fgf10 fgf2 foxo1 guarana klf2 lep lpl mate ppargamma2 resveratrol sirt2 srebf1 synergy ucp1 yerba ygd	adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly setdb1 t98g verified
Tagcloud (Intersection) ?