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KLF15 and PRKAB2
Number of citations of the paper that reports this interaction (PMID
24722188
)
1
Data Source:
BioGRID
(two hybrid, two hybrid)
KLF15
PRKAB2
Gene Name
Kruppel-like factor 15
protein kinase, AMP-activated, beta 2 non-catalytic subunit
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
AMP-activated Protein Kinase Complex
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
Protein Binding
Transcription Regulatory Region DNA Binding
Metal Ion Binding
AMP-activated Protein Kinase Activity
Protein Binding
Identical Protein Binding
Biological Process
Transcription, DNA-templated
Glial Cell Differentiation
Cardiac Muscle Hypertrophy In Response To Stress
Glucose Transport
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Glomerular Visceral Epithelial Cell Differentiation
Cellular Response To Peptide
Negative Regulation Of Peptidyl-lysine Acetylation
Energy Reserve Metabolic Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Carnitine Shuttle
Organelle Organization
Mitochondrion Organization
Cell Cycle Arrest
Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Fatty Acid Biosynthetic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Regulation Of Protein Kinase Activity
Membrane Organization
Pathways
Organelle biogenesis and maintenance
Integration of energy metabolism
Metabolism of lipids and lipoproteins
Regulation of Rheb GTPase activity by AMPK
IRS-mediated signalling
mTOR signalling
Translocation of GLUT4 to the plasma membrane
Import of palmitoyl-CoA into the mitochondrial matrix
mTOR signalling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Energy dependent regulation of mTOR by LKB1-AMPK
PKB-mediated events
PI3K Cascade
Signaling by Insulin receptor
Fatty acid, triacylglycerol, and ketone body metabolism
Insulin receptor signalling cascade
Regulation of AMPK activity via LKB1
IRS-related events
Mitochondrial biogenesis
IRS-mediated signalling
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
AMPK inhibits chREBP transcriptional activation activity
PKB-mediated events
PI3K Cascade
Drugs
Adenosine monophosphate
Diseases
GWAS
Metabolite levels (
23378610
)
Protein-Protein Interactions
5 interactors:
PRKAB2
SNX13
SUV39H1
TCF21
ZBTB24
70 interactors:
ADAMTSL4
BANP
BEND5
BLZF1
CALCOCO2
CASP6
CCDC33
CCDC36
CDX4
CREB3L1
CRX
CSNK2B
DAO
DDIT4L
DICER1
DST
EPM2A
FAM208B
FDX1
FLNC
GATA1
GATAD2B
GET4
GNB2L1
GOLGA2
GRN
IKZF1
IKZF3
KCTD5
KLF15
KRT40
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-12
KRTAP4-2
KRTAP5-9
KRTAP9-2
KRTAP9-4
LZTS2
MAGED1
MDFI
MEOX2
NEBL
PIAS2
PRDM14
PRKAA1
PRKAA2
PRKAG1
PRKAG2
PRKAG3
PSME3
PYGM
RBPMS
REL
RHEBL1
RIMBP3
SPRY2
STX11
STX19
TADA2A
TCF4
TP53BP2
TRAF2
TRIM10
UBXN11
YY1AP1
ZBTB32
Entrez ID
28999
5565
HPRD ID
07568
04117
Ensembl ID
ENSG00000163884
ENSG00000131791
Uniprot IDs
Q9UIH9
O43741
PDB IDs
2ENT
2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2Y94
2YA3
4EAI
4EAJ
Enriched GO Terms of Interacting Partners
?
Bronchiole Development
Metanephric Mesenchymal Cell Differentiation
Branchiomeric Skeletal Muscle Development
Metanephric Glomerular Capillary Formation
Histone H3-K9 Dimethylation
Carnitine Shuttle
Glomerular Capillary Formation
Mesenchymal Cell Differentiation Involved In Kidney Development
Lung Vasculature Development
Histone H3-K9 Trimethylation
Metanephric Glomerulus Vasculature Development
Carnitine Transmembrane Transport
Diaphragm Development
Carnitine Transport
Peptidyl-lysine Dimethylation
Cell Differentiation Involved In Metanephros Development
Negative Regulation Of Androgen Receptor Signaling Pathway
Regulation Of Metabolic Process
Chromatin Silencing At RDNA
Metanephric Glomerulus Development
Glomerulus Morphogenesis
Metanephric Mesenchyme Development
Quaternary Ammonium Group Transport
Negative Regulation Of Circadian Rhythm
Regulation Of Androgen Receptor Signaling Pathway
Histone H3-K9 Methylation
Glomerulus Vasculature Development
Sex Determination
Peptidyl-lysine Trimethylation
Embryonic Digestive Tract Morphogenesis
Sertoli Cell Differentiation
Regulation Of Fatty Acid Biosynthetic Process
Biosynthetic Process
Chromatin Silencing
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Histone H3-K9 Modification
Transcription, DNA-templated
Immune System Development
Cell Differentiation Involved In Kidney Development
Metanephric Nephron Development
Long-chain Fatty Acid Transport
RNA Biosynthetic Process
Ammonium Transmembrane Transport
Embryonic Digestive Tract Development
Spleen Development
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cell Cycle Arrest
Transcription, DNA-templated
Regulation Of Gene Expression
RNA Biosynthetic Process
Glycogen Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Glycolytic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Phosphorylation
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Modification Process
Negative Regulation Of Cell Cycle
Energy Reserve Metabolic Process
Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Polysaccharide Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Macromolecule Biosynthetic Process
Organelle Organization
Gene Expression
Cell Cycle Process
Positive Regulation Of Phosphorylation
RNA Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Protein Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Signaling
Fatty Acid Biosynthetic Process
Cellular Process
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Transcription From RNA Polymerase II Promoter
Regulation Of Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Binding
Regulation Of Metabolic Process
Regulation Of Carbohydrate Metabolic Process
Regulation Of Phosphorylation
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Cell Death
Tagcloud
?
adig
adipogenesis
adipogenic
axin
bmp2
cebpa
cebpb
damiana
ddit3
dlk
ebpalpha
fasn
favors
fgf10
fgf2
foxo1
guarana
klf2
lep
lpl
mate
ppargamma2
resveratrol
sirt2
srebf1
synergy
ucp1
yerba
ygd
Tagcloud (Difference)
?
adig
adipogenesis
adipogenic
axin
bmp2
cebpa
cebpb
damiana
ddit3
dlk
ebpalpha
fasn
favors
fgf10
fgf2
foxo1
guarana
klf2
lep
lpl
mate
ppargamma2
resveratrol
sirt2
srebf1
synergy
ucp1
yerba
ygd
Tagcloud (Intersection)
?