KLF15 and TCF21

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		KLF15	TCF21
Gene Name		Kruppel-like factor 15	transcription factor 21
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Histone Deacetylase Binding BHLH Transcription Factor Binding Protein Dimerization Activity Androgen Receptor Binding E-box Binding
	Biological Process	Transcription, DNA-templated Glial Cell Differentiation Cardiac Muscle Hypertrophy In Response To Stress Glucose Transport Positive Regulation Of Transcription From RNA Polymerase II Promoter Glomerular Visceral Epithelial Cell Differentiation Cellular Response To Peptide Negative Regulation Of Peptidyl-lysine Acetylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Branching Structure Kidney Development Vasculature Development Transcription, DNA-templated Sex Determination Branchiomeric Skeletal Muscle Development Epithelial Cell Differentiation Glomerulus Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Spleen Development Embryonic Digestive Tract Morphogenesis Reproductive Structure Development Gland Development Sertoli Cell Differentiation Palate Development Lung Morphogenesis Lung Vasculature Development Bronchiole Development Diaphragm Development Respiratory System Development Negative Regulation Of Androgen Receptor Signaling Pathway Metanephric Mesenchymal Cell Differentiation Metanephric Glomerular Capillary Formation
Pathways
Drugs
Diseases
GWAS		Metabolite levels ( 23378610)	Coronary heart disease ( 22751097 21378990)
Protein-Protein Interactions		5 interactors: PRKAB2 SNX13 SUV39H1 TCF21 ZBTB24	7 interactors: APEX1 APLP1 GTF3C5 HOXB6 KLF15 LMO4 TCF3
Entrez ID		28999	6943
HPRD ID		07568	04493
Ensembl ID		ENSG00000163884	ENSG00000118526
Uniprot IDs		Q9UIH9	O43680
PDB IDs		2ENT
Enriched GO Terms of Interacting Partners?		Bronchiole Development Metanephric Mesenchymal Cell Differentiation Branchiomeric Skeletal Muscle Development Metanephric Glomerular Capillary Formation Histone H3-K9 Dimethylation Carnitine Shuttle Glomerular Capillary Formation Mesenchymal Cell Differentiation Involved In Kidney Development Lung Vasculature Development Histone H3-K9 Trimethylation Metanephric Glomerulus Vasculature Development Carnitine Transmembrane Transport Diaphragm Development Carnitine Transport Peptidyl-lysine Dimethylation Cell Differentiation Involved In Metanephros Development Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Metabolic Process Chromatin Silencing At RDNA Metanephric Glomerulus Development Glomerulus Morphogenesis Metanephric Mesenchyme Development Quaternary Ammonium Group Transport Negative Regulation Of Circadian Rhythm Regulation Of Androgen Receptor Signaling Pathway Histone H3-K9 Methylation Glomerulus Vasculature Development Sex Determination Peptidyl-lysine Trimethylation Embryonic Digestive Tract Morphogenesis Sertoli Cell Differentiation Regulation Of Fatty Acid Biosynthetic Process Biosynthetic Process Chromatin Silencing Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Histone H3-K9 Modification Transcription, DNA-templated Immune System Development Cell Differentiation Involved In Kidney Development Metanephric Nephron Development Long-chain Fatty Acid Transport RNA Biosynthetic Process Ammonium Transmembrane Transport Embryonic Digestive Tract Development Spleen Development Negative Regulation Of Transcription From RNA Polymerase II Promoter	RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organ Development Developmental Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process System Development Posttranscriptional Regulation Of Gene Expression Cellular Response To Organonitrogen Compound Multicellular Organismal Development Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Cellular Response To Norepinephrine Stimulus Response To Organonitrogen Compound Transcription From RNA Polymerase II Promoter 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter Axial Mesoderm Morphogenesis Response To Norepinephrine Negative Regulation Of Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Immunoglobulin V(D)J Recombination TRNA Transcription DNA Recombination Central Nervous System Development Anterior/posterior Pattern Specification Nervous System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Axial Mesoderm Development Cellular Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis B Cell Lineage Commitment Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process
Tagcloud ?		adig adipogenesis adipogenic axin bmp2 cebpa cebpb damiana ddit3 dlk ebpalpha fasn favors fgf10 fgf2 foxo1 guarana klf2 lep lpl mate ppargamma2 resveratrol sirt2 srebf1 synergy ucp1 yerba ygd	biologic clustering commitment derivation deviant dissemination etiologies evasion fallopian fimbrial fn1 hgsc homeostatic incidences metastasize modules niche pax8 peg3 quiescence slug sparc speculated speculation subsistence survive thbs2 theme totally
Tagcloud (Difference) ?		adig adipogenesis adipogenic axin bmp2 cebpa cebpb damiana ddit3 dlk ebpalpha fasn favors fgf10 fgf2 foxo1 guarana klf2 lep lpl mate ppargamma2 resveratrol sirt2 srebf1 synergy ucp1 yerba ygd	biologic clustering commitment derivation deviant dissemination etiologies evasion fallopian fimbrial fn1 hgsc homeostatic incidences metastasize modules niche pax8 peg3 quiescence slug sparc speculated speculation subsistence survive thbs2 theme totally
Tagcloud (Intersection) ?