CDC6 and RPS27A

Number of citations of the paper that reports this interaction (PMID 10995389)
80

Data Source:
HPRD (in vivo)

		CDC6	RPS27A
Gene Name		cell division cycle 6	ribosomal protein S27a
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Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Spindle Midzone	Nucleoplasm Cytosol Plasma Membrane Endosome Membrane Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding Chromatin Binding Protein Binding ATP Binding Kinase Binding	Structural Constituent Of Ribosome Poly(A) RNA Binding Metal Ion Binding
	Biological Process	DNA Replication Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Cell Division Positive Regulation Of Chromosome Segregation	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Activation Of MAPK Activity Protein Polyubiquitination Mitotic Cell Cycle Toll-like Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process DNA Repair Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Gene Expression Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Viral Transcription Cytokine-mediated Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Ion Transmembrane Transport TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Metabolic Process Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Transmembrane Transport Membrane Organization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Hypoxia Intracellular Transport Of Virus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway
Pathways		CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition G0 and Early G1 S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin Cell Cycle Checkpoints CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Hedgehog 'off' state Signaling by FGFR in disease Influenza Life Cycle Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Formation of the ternary complex, and subsequently, the 43S complex Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Influenza Infection Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding HIV Infection Peptide chain elongation Assembly of the pre-replicative complex Activated TLR4 signalling Synthesis And Processing Of GAG, GAGPOL Polyproteins S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response Signaling by NOTCH1 PEST Domain Mutants in Cancer regulation of FZD by ubiquitination Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels p53-Independent G1/S DNA damage checkpoint Membrane binding and targetting of GAG proteins G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling Eukaryotic Translation Termination M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome Cell Cycle Checkpoints degradation of DVL Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Translation initiation complex formation Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Generic Transcription Pathway Regulation of the Fanconi anemia pathway G1/S Transition FBXW7 Mutants and NOTCH1 in Cancer Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex truncations of AMER1 destabilize the destruction complex Negative regulation of FGFR signaling EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Translation IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Host Interactions of HIV factors Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Fc epsilon receptor (FCERI) signaling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex APC truncation mutants are not K63 polyubiquitinated M Phase Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Viral mRNA Translation Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Formation of a pool of free 40S subunits TRAF6 mediated induction of TAK1 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease Cellular Senescence T41 mutants of beta-catenin aren't phosphorylated SMAD2/3 MH2 Domain Mutants in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Downstream signaling events of B Cell Receptor (BCR) Assembly Of The HIV Virion Degradation of beta-catenin by the destruction complex Influenza Viral RNA Transcription and Replication NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Glycogen storage diseases Cap-dependent Translation Initiation Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer Regulation of APC/C activators between G1/S and early anaphase L13a-mediated translational silencing of Ceruloplasmin expression Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-1 signaling Eukaryotic Translation Elongation PCP/CE pathway Mitotic G2-G2/M phases Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport Eukaryotic Translation Initiation p75NTR signals via NF-kB Regulation of signaling by CBL Disease XAV939 inhibits tankyrase, stabilizing AXIN TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Nonsense-Mediated Decay (NMD) Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus Toll-Like Receptors Cascades NOTCH1 Intracellular Domain Regulates Transcription Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex SRP-dependent cotranslational protein targeting to membrane Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by EGFR in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling Ribosomal scanning and start codon recognition RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin GTP hydrolysis and joining of the 60S ribosomal subunit Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A TERF1 UBE2K UBR1	25 interactors: ACVR1 APP BMPR1B CALCOCO2 CDC6 CDK11B DAZAP2 DNAJB2 FSHR GGA1 GGA3 KANSL3 MAST2 MDM2 PAXIP1 POLH RABGEF1 RNF11 SMAD1 SMAD2 SMAD4 SMURF1 SMURF2 TGFBR1 ZNF512B
Entrez ID		990	6233
HPRD ID		04022	01878
Ensembl ID		ENSG00000094804	ENSG00000143947
Uniprot IDs		Q99741	B2RDW1 P62979
PDB IDs		2CCH 2CCI 4I5L 4I5N	2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3J3A 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Replication DNA Metabolic Process Regulation Of Cell Cycle DNA Replication Initiation Cell Cycle Checkpoint DNA-dependent DNA Replication Negative Regulation Of Cell Cycle Cell Division Cellular Metabolic Process Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Checkpoint Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Protein Modification Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Mitotic DNA Damage Checkpoint Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Proteolysis Positive Regulation Of Cell Cycle Process	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Protein Modification Process Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Growth Factor Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Complex Assembly Regulation Of Metabolic Process Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Activin Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Cellular Response To Growth Factor Stimulus Pattern Specification Process Traversing Start Control Point Of Mitotic Cell Cycle Protein Metabolic Process Cell Fate Commitment Sexual Reproduction Mesoderm Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Endocardial Cell Differentiation Primary MiRNA Processing Regulation Of RNA Metabolic Process Regulation Of Epithelial To Mesenchymal Transition Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Endothelial Cell Activation Protein Phosphorylation Positive Regulation Of Cell Cycle Phase Transition Gastrulation Urogenital System Development Gamete Generation Positive Regulation Of Metabolic Process Regulation Of Ossification
Tagcloud ?		antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed	amplifies appears arrest biogenesis blocked checkpoints cycle damage direct dominant ectopically elevated interference links mutant overexpressed p21waf1 p53 play progression response ribosomal ribosome sensor small specifically target transcriptional via
Tagcloud (Difference) ?		antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed	amplifies appears arrest biogenesis blocked checkpoints cycle damage direct dominant ectopically elevated interference links mutant overexpressed p21waf1 p53 play progression response ribosomal ribosome sensor small specifically target transcriptional via
Tagcloud (Intersection) ?