CDC6 and KAT7

Number of citations of the paper that reports this interaction (PubMedID 16428461)
50

Data Source:
BioGRID (enzymatic study)

		CDC6	KAT7
Description		cell division cycle 6	lysine acetyltransferase 7
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Cytosol Intercellular Bridge Spindle Midzone Mitotic Spindle	Histone Acetyltransferase Complex Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Histone H3-K14 Acetyltransferase Complex Site Of DNA Damage
	Molecular Function	Nucleotide Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding Protein Serine/threonine Kinase Binding	Chromatin Binding DNA Replication Origin Binding Transcription Coregulator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H3 Acetyltransferase Activity Histone H4 Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone H3K14 Acetyltransferase Activity Histone H3K23 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity
	Biological Process	DNA Replication Checkpoint Signaling Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Replication DNA Replication Initiation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Mitotic DNA Replication Checkpoint Signaling Positive Regulation Of Fibroblast Proliferation Cell Division Positive Regulation Of Chromosome Segregation Cellular Response To Vasopressin Cellular Response To Angiotensin	Regulation Of Cell Growth Natural Killer Cell Differentiation DNA Replication Regulation Of DNA Replication DNA Repair Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Internal Peptidyl-lysine Acetylation Regulation Of DNA-templated DNA Replication Initiation T Cell Differentiation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA Replication Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Response To Sorbitol Response To Hydroxyurea Response To Actinomycin D Response To Dithiothreitol Response To Anisomycin DNA Replication-dependent Chromatin Disassembly Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of DNA Biosynthetic Process Regulation Of Nucleotide-excision Repair
Pathways		Transcription of E2F targets under negative control by DREAM complex Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription	HATs acetylate histones
Drugs
Diseases
GWAS		Asthma ( 31619474)	Mean corpuscular hemoglobin ( 27863252 29403010) Mean corpuscular volume ( 27863252 29403010) Mean reticulocyte volume ( 32888494)
Interacting Genes		40 interacting genes: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FAM13A-AS1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC OGT ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PLK1 PPP2R3A PPP2R3B PSKH1 RPS27A SQSTM1 TERF1 UBC UBE2K UBR1	45 interacting genes: APP AR ATN1 BARD1 BGLT3 CAAP1 CALCOCO2 CBX8 CDC6 CDK11B CEP126 CEP70 CSNK1E DDX11 DVL3 DYNC1I1 GMNN H2AC20 H3C1 H4C1 HAP1 HOOK2 ING4 KATNBL1 KCTD13 LRIF1 MAP2K1 MCM2 MCRS1 NINL ORC1 ORC2 PACSIN1 POLB PPID RGL2 RPS10 SAT1 SEPTIN5 SNAPIN TP53 VIM WDR33 ZBTB8A ZNF165
Entrez ID		990	11143
HPRD ID		04022	07135
Ensembl ID		ENSG00000094804	ENSG00000136504
Uniprot IDs		Q99741	A0A9L9PXR9 O95251
PDB IDs		2CCH 2CCI 4I5L 4I5N 8HT7 8RWV 8S0E	5GK9 6MAJ 6MAK 7D0O 7D0P 7D0Q 7D0R 7D0S
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication Regulation Of DNA Replication Nucleoplasm DNA Metabolic Process DNA Replication Origin Binding Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Chromosome, Telomeric Region Regulation Of Cell Cycle Process Origin Recognition Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Nucleic Acid Metabolic Process Regulation Of DNA-templated DNA Replication Initiation Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Cell Cycle G1/S Phase Transition Cell Division Regulation Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cellular Response To Stress Negative Regulation Of Cell Cycle Process DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Cell Cycle G2/M Phase Transition Protein Modification Process Positive Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Regulation Of Primary Metabolic Process Chromosome Positive Regulation Of DNA Replication Regulation Of DNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Fibroblast Proliferation Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Nucleolus	DNA Replication Origin Binding Nucleus Regulation Of DNA Metabolic Process DNA Replication Initiation Regulation Of DNA Replication Nuclear Origin Of Replication Recognition Complex Chromatin Organization DNA Metabolic Process DNA Replication Chromatin Remodeling Centrosome Vesicle Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Cytoskeleton Vesicle Cytoskeletal Trafficking Regulation Of Cell Cycle G2/M Phase Transition Chromatin Binding Nucleoplasm Negative Regulation Of DNA Replication Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair Spindle Pole Regulation Of Cellular Response To Stress Organelle Transport Along Microtubule Transport Along Microtubule Regulation Of Cellular Component Organization Chromosome, Telomeric Region Origin Recognition Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Component Organization Organelle Organization Positive Regulation Of Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Establishment Of Vesicle Localization Microtubule-based Process Microtubule-based Transport Regulation Of Macromolecule Metabolic Process Protein Heterodimerization Activity Supramolecular Fiber Organization Mitotic DNA Replication Checkpoint Signaling Vesicle Localization Bergmann Glial Cell Differentiation Transcription Coactivator Binding Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Cell Cycle Chromosome Mitotic G2/M Transition Checkpoint Negative Regulation Of Metabolic Process Nuclear Matrix Regulation Of Primary Metabolic Process
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