CDC6 and FAM13A-AS1

Number of citations of the paper that reports this interaction (PubMedID 37330023)
0

Data Source:
BioGRID (unspecified method)

		CDC6	FAM13A-AS1
Description		cell division cycle 6	FAM13A antisense RNA 1
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Cytosol Intercellular Bridge Spindle Midzone Mitotic Spindle
	Molecular Function	Nucleotide Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding Protein Serine/threonine Kinase Binding
	Biological Process	DNA Replication Checkpoint Signaling Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Replication DNA Replication Initiation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Mitotic DNA Replication Checkpoint Signaling Positive Regulation Of Fibroblast Proliferation Cell Division Positive Regulation Of Chromosome Segregation Cellular Response To Vasopressin Cellular Response To Angiotensin
Pathways		Transcription of E2F targets under negative control by DREAM complex Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription
Drugs
Diseases
GWAS		Asthma ( 31619474)	A body shape index ( 34021172) Hair greying ( 26926045) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		40 interacting genes: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FAM13A-AS1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC OGT ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PLK1 PPP2R3A PPP2R3B PSKH1 RPS27A SQSTM1 TERF1 UBC UBE2K UBR1	4 interacting genes: ARRDC1 ATF2 CDC6 PPARG
Entrez ID		990	285512
HPRD ID		04022
Ensembl ID		ENSG00000094804
Uniprot IDs		Q99741
PDB IDs		2CCH 2CCI 4I5L 4I5N 8HT7 8RWV 8S0E
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication Regulation Of DNA Replication Nucleoplasm DNA Metabolic Process DNA Replication Origin Binding Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Chromosome, Telomeric Region Regulation Of Cell Cycle Process Origin Recognition Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Nucleic Acid Metabolic Process Regulation Of DNA-templated DNA Replication Initiation Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Cell Cycle G1/S Phase Transition Cell Division Regulation Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cellular Response To Stress Negative Regulation Of Cell Cycle Process DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Cell Cycle G2/M Phase Transition Protein Modification Process Positive Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Regulation Of Primary Metabolic Process Chromosome Positive Regulation Of DNA Replication Regulation Of DNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Fibroblast Proliferation Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Nucleolus	White Fat Cell Differentiation Mitotic DNA Integrity Checkpoint Signaling Chromatin Binding MRNA Transcription MRNA Transcription By RNA Polymerase II Cellular Response To Peptide Hormone Stimulus Abducens Nucleus Development Cellular Response To Anisomycin Growth Plate Cartilage Chondrocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Positive Regulation Of Cardiac Muscle Myoblast Proliferation Facial Nucleus Development Fat Cell Differentiation Histone H2B Acetyltransferase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Hypoglossal Nucleus Development Negative Regulation Of Vasculature Development H4 Histone Acetyltransferase Complex Positive Regulation Of Transforming Growth Factor Beta2 Production Growth Plate Cartilage Chondrocyte Proliferation Negative Regulation Of Angiogenesis BMP Signaling Pathway RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Positive Regulation Of Adiponectin Secretion Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Response To Anisomycin NK T Cell Differentiation Detection Of Cell Density Prostaglandin Receptor Activity DNA Binding Domain Binding Extracellular Vesicle Biogenesis Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Lipoprotein Transport Negative Regulation Of Mitochondrial Fission Arachidonate Binding Negative Regulation Of Cell Cycle Process Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Negative Regulation Of Type II Interferon-mediated Signaling Pathway LBD Domain Binding Cellular Response To Vasopressin Response To Peptide Hormone Brainstem Development Transcription By RNA Polymerase II Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Hormone Stimulus Mitotic DNA Replication Checkpoint Signaling Regulation Of Vasculature Development
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