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CDC6 and ORC1
Number of citations of the paper that reports this interaction (PubMedID
12912926
)
46
Data Source:
BioGRID
(biochemical, affinity chromatography technology, pull down)
HPRD
(in vitro, in vivo)
CDC6
ORC1
Description
cell division cycle 6
origin recognition complex subunit 1
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Spindle
Cytosol
Intercellular Bridge
Spindle Midzone
Mitotic Spindle
Chromosome, Telomeric Region
Origin Recognition Complex
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Cytosol
Molecular Function
Nucleotide Binding
Chromatin Binding
DNA Replication Origin Binding
Protein Binding
ATP Binding
Protein Serine/threonine Kinase Binding
Nucleotide Binding
DNA Binding
Chromatin Binding
DNA Replication Origin Binding
Protein Binding
ATP Binding
ATP Hydrolysis Activity
Metal Ion Binding
Biological Process
DNA Replication Checkpoint Signaling
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
DNA Replication
DNA Replication Initiation
Traversing Start Control Point Of Mitotic Cell Cycle
Negative Regulation Of DNA Replication
Negative Regulation Of Cell Population Proliferation
Regulation Of Mitotic Metaphase/anaphase Transition
Positive Regulation Of Cytokinesis
Mitotic DNA Replication Checkpoint Signaling
Positive Regulation Of Fibroblast Proliferation
Cell Division
Positive Regulation Of Chromosome Segregation
Cellular Response To Vasopressin
Cellular Response To Angiotensin
DNA Replication
DNA Replication Initiation
Mitotic DNA Replication Checkpoint Signaling
Pathways
Transcription of E2F targets under negative control by DREAM complex
Activation of ATR in response to replication stress
CDC6 association with the ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
G1/S-Specific Transcription
E2F-enabled inhibition of pre-replication complex formation
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
G1/S-Specific Transcription
Drugs
Diseases
Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS
Asthma (
31619474
)
Interacting Genes
40 interacting genes:
AKAP8L
ATM
ATRIP
B3GALNT1
CCNA2
CCNB1
CCNE1
CDC14A
CDC20
CDK2
CDK4
CDK6
CDKN1A
CDKN2A
CDT1
FAM13A-AS1
FZR1
KAT7
MCM10
MCM2
MCM3
MCM7
MYC
OGT
ORC1
ORC2
ORC3
ORC5
ORC6
PCNA
PLK1
PPP2R3A
PPP2R3B
PSKH1
RPS27A
SQSTM1
TERF1
UBC
UBE2K
UBR1
25 interacting genes:
CDC45
CDC5L
CDC6
CDC7
CDK2
CDT1
DBF4
GOLGA2
GOLGA6L9
H4C1
KAT7
MCM2
MCM4
MCM5
MCM6
MCM7
ORC2
ORC3
ORC4
ORC5
RB1
RFWD3
RPA2
SKP2
XPO1
Entrez ID
990
4998
HPRD ID
04022
03544
Ensembl ID
ENSG00000094804
ENSG00000085840
Uniprot IDs
Q99741
B7Z8H0
Q13415
Q96F82
PDB IDs
2CCH
2CCI
4I5L
4I5N
8HT7
8RWV
8S0E
5UJ7
5UJM
6P3W
7CTF
7CTG
7JPO
7JPP
7JPR
7JPS
8RWV
8S0C
8S0D
8S0E
8S0F
Enriched GO Terms of Interacting Partners
?
DNA Replication Initiation
DNA Replication
Regulation Of DNA Replication
Nucleoplasm
DNA Metabolic Process
DNA Replication Origin Binding
Nuclear Origin Of Replication Recognition Complex
Regulation Of DNA Metabolic Process
Regulation Of Cell Cycle Phase Transition
Cell Cycle Phase Transition
Chromosome, Telomeric Region
Regulation Of Cell Cycle Process
Origin Recognition Complex
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle
Nucleic Acid Metabolic Process
Regulation Of DNA-templated DNA Replication Initiation
Mitotic Cell Cycle Phase Transition
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Macromolecule Metabolic Process
Regulation Of Cell Cycle G2/M Phase Transition
Cyclin-dependent Protein Kinase Holoenzyme Complex
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle
Cell Cycle G1/S Phase Transition
Cell Division
Regulation Of Mitotic Cell Cycle
Nucleobase-containing Compound Metabolic Process
Nucleus
Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Cellular Response To Stress
Negative Regulation Of Cell Cycle Process
DNA Damage Response
Negative Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Fibroblast Proliferation
Cell Cycle G2/M Phase Transition
Protein Modification Process
Positive Regulation Of DNA Metabolic Process
Mitotic DNA Integrity Checkpoint Signaling
Regulation Of Primary Metabolic Process
Chromosome
Positive Regulation Of DNA Replication
Regulation Of DNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Fibroblast Proliferation
Chromosome Organization
Negative Regulation Of Mitotic Cell Cycle Phase Transition
DNA Damage Checkpoint Signaling
G2/M Transition Of Mitotic Cell Cycle
Nucleolus
DNA Replication
DNA Replication Initiation
DNA Metabolic Process
DNA Replication Origin Binding
Regulation Of DNA Replication
Regulation Of DNA-templated DNA Replication Initiation
Double-strand Break Repair Via Break-induced Replication
Chromosome, Telomeric Region
Regulation Of DNA Metabolic Process
Nucleic Acid Metabolic Process
CMG Complex
Nucleobase-containing Compound Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Nuclear Origin Of Replication Recognition Complex
Recombinational Repair
Nucleoplasm
MCM Complex
DNA Repair
Double-strand Break Repair
DNA Recombination
Origin Recognition Complex
Single-stranded DNA Binding
DNA Damage Response
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Phase Transition
Chromosome
Macromolecule Metabolic Process
Regulation Of Cell Cycle Process
Positive Regulation Of DNA Replication
Negative Regulation Of Cell Cycle Process
Positive Regulation Of DNA-templated DNA Replication
Nucleus
Single-stranded DNA Helicase Activity
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cell Cycle
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
DNA Helicase Activity
Regulation Of Primary Metabolic Process
Regulation Of Nuclear Cell Cycle DNA Replication
Cellular Response To Stress
Helicase Activity
Mitotic G1 DNA Damage Checkpoint Signaling
Mitotic G1/S Transition Checkpoint Signaling
DNA Replication Preinitiation Complex
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
DNA Replication Checkpoint Signaling
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