CDC6 and B3GALNT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CDC6	B3GALNT1
Description		cell division cycle 6	beta-1,3-N-acetylgalactosaminyltransferase 1 (Globoside blood group)
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Cytosol Intercellular Bridge Spindle Midzone Mitotic Spindle	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Nucleotide Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding Protein Serine/threonine Kinase Binding	N-acetyl-beta-D-glucosaminide Beta-(1,3)-galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity Galactosylgalactosylglucosylceramide Beta-D-acetylgalactosaminyltransferase Activity
	Biological Process	DNA Replication Checkpoint Signaling Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Replication DNA Replication Initiation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Mitotic DNA Replication Checkpoint Signaling Positive Regulation Of Fibroblast Proliferation Cell Division Positive Regulation Of Chromosome Segregation Cellular Response To Vasopressin Cellular Response To Angiotensin	Protein Glycosylation Protein O-linked Glycosylation Lipid Metabolic Process Glycosphingolipid Biosynthetic Process Oligosaccharide Biosynthetic Process Carbohydrate Derivative Biosynthetic Process
Pathways		Transcription of E2F targets under negative control by DREAM complex Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription	Glycosphingolipid biosynthesis
Drugs
Diseases
GWAS		Asthma ( 31619474)	Chronotype ( 30696823) Malaria ( 31844061) Menarche (age at onset) ( 23599027) Morning person ( 30696823)
Interacting Genes		40 interacting genes: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FAM13A-AS1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC OGT ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PLK1 PPP2R3A PPP2R3B PSKH1 RPS27A SQSTM1 TERF1 UBC UBE2K UBR1	1 interacting genes: CDC6
Entrez ID		990	8706
HPRD ID		04022	09119
Ensembl ID		ENSG00000094804	ENSG00000169255
Uniprot IDs		Q99741	B3KTQ4 O75752 Q49AT3 Q7L9G8
PDB IDs		2CCH 2CCI 4I5L 4I5N 8HT7 8RWV 8S0E
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication Regulation Of DNA Replication Nucleoplasm DNA Metabolic Process DNA Replication Origin Binding Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Chromosome, Telomeric Region Regulation Of Cell Cycle Process Origin Recognition Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Nucleic Acid Metabolic Process Regulation Of DNA-templated DNA Replication Initiation Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Cell Cycle G1/S Phase Transition Cell Division Regulation Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cellular Response To Stress Negative Regulation Of Cell Cycle Process DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Cell Cycle G2/M Phase Transition Protein Modification Process Positive Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Regulation Of Primary Metabolic Process Chromosome Positive Regulation Of DNA Replication Regulation Of DNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Fibroblast Proliferation Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Nucleolus	DNA Replication Checkpoint Signaling Negative Regulation Of DNA Replication DNA Replication Initiation Cellular Response To Vasopressin Response To Angiotensin Cellular Response To Angiotensin Traversing Start Control Point Of Mitotic Cell Cycle Spindle Midzone Protein Serine/threonine Kinase Binding Mitotic DNA Replication Checkpoint Signaling DNA Replication Origin Binding Positive Regulation Of Chromosome Segregation Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cytokinesis Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Sister Chromatid Segregation Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Division Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cytokinesis Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Fibroblast Proliferation Regulation Of DNA Replication Intercellular Bridge Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Chromosome Segregation Mitotic Spindle Positive Regulation Of Mitotic Cell Cycle DNA Replication Spindle Pole Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Peptide Hormone Stimulus Regulation Of Cell Division Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Protein Kinase Activity Spindle Regulation Of Chromosome Organization Regulation Of Kinase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?