CDC6 and PPP2R3A

Number of citations of the paper that reports this interaction (PMID 10629059)
24

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (two hybrid)

		CDC6	PPP2R3A
Gene Name		cell division cycle 6	protein phosphatase 2, regulatory subunit B, alpha
Image
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Spindle Midzone	Protein Phosphatase Type 2A Complex
	Molecular Function	Nucleotide Binding Chromatin Binding Protein Binding ATP Binding Kinase Binding	Calcium Ion Binding Protein Binding Protein Phosphatase Type 2A Regulator Activity
	Biological Process	DNA Replication Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Cell Division Positive Regulation Of Chromosome Segregation	Eye Photoreceptor Cell Differentiation Protein Dephosphorylation Somatic Muscle Development Positive Regulation Of Protein Catabolic Process Regulation Of Catalytic Activity Somite Development Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Cell Motility Involved In Somitogenic Axis Elongation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition G0 and Early G1 S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin Cell Cycle Checkpoints CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex
Drugs
Diseases
GWAS			Anticoagulant levels ( 22216198)
Protein-Protein Interactions		36 interactors: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A TERF1 UBE2K UBR1	8 interactors: AKAP9 ATXN7L2 CDC6 HMGB1 PPP2CA PPP2R4 PPP5C RBL1
Entrez ID		990	5523
HPRD ID		04022	09225
Ensembl ID		ENSG00000094804	ENSG00000073711
Uniprot IDs		Q99741	Q06190
PDB IDs		2CCH 2CCI 4I5L 4I5N	4I5J 4I5K
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Replication DNA Metabolic Process Regulation Of Cell Cycle DNA Replication Initiation Cell Cycle Checkpoint DNA-dependent DNA Replication Negative Regulation Of Cell Cycle Cell Division Cellular Metabolic Process Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Checkpoint Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Protein Modification Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Mitotic DNA Damage Checkpoint Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Proteolysis Positive Regulation Of Cell Cycle Process	Mitotic Cell Cycle Cell Cycle Mitotic Cell Cycle Process Organelle Organization Cell Cycle Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Mitotic Spindle Organization In Nucleus Negative Regulation Of Apoptotic Cell Clearance Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Regulation Of DNA Replication Protein Heterooligomerization Positive Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Regulation Of Kinase Activity Base-excision Repair, DNA Ligation Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Protein Modification Process Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Protein Dephosphorylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Metabolic Process Negative Regulation Of Phosphoprotein Phosphatase Activity Mitotic Nuclear Envelope Reassembly DNA Metabolic Process Regulation Of Protein Phosphorylation DNA Ligation Involved In DNA Repair DNA Replication Checkpoint Protein Heterotrimerization Regulation Of Apoptotic Cell Clearance Response To Organic Substance Nuclear Envelope Reassembly Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Phagocytosis Mitotic Nuclear Division Nucleobase-containing Compound Metabolic Process Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization DNA Ligation
Tagcloud ?		antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed	aza basonuclin bnc1 childhood demonstrating deoxycytidine epigenetic epigenetically fbln2 fibulin frequent frequently homeobox identification inactivated inactivation leukemia lymphoblastic methylated methylation microarray msh msx1 noti restored screens showing thrb whilst
Tagcloud (Difference) ?		antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed	aza basonuclin bnc1 childhood demonstrating deoxycytidine epigenetic epigenetically fbln2 fibulin frequent frequently homeobox identification inactivated inactivation leukemia lymphoblastic methylated methylation microarray msh msx1 noti restored screens showing thrb whilst
Tagcloud (Intersection) ?