CDC6 and ORC3

Number of citations of the paper that reports this interaction (PubMedID 15232106)
0

Data Source:
HPRD (in vitro)

		CDC6	ORC3
Description		cell division cycle 6	origin recognition complex subunit 3
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Cytosol Intercellular Bridge Spindle Midzone Mitotic Spindle	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Pre-replicative Complex Nuclear Origin Of Replication Recognition Complex Chromosome Nuclear Body DNA Replication Preinitiation Complex
	Molecular Function	Nucleotide Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding Protein Serine/threonine Kinase Binding	DNA Binding DNA Replication Origin Binding Protein Binding
	Biological Process	DNA Replication Checkpoint Signaling Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Replication DNA Replication Initiation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Mitotic DNA Replication Checkpoint Signaling Positive Regulation Of Fibroblast Proliferation Cell Division Positive Regulation Of Chromosome Segregation Cellular Response To Vasopressin Cellular Response To Angiotensin	DNA Replication DNA Replication Initiation Regulation Of DNA Replication Glial Cell Proliferation Neural Precursor Cell Proliferation
Pathways		Transcription of E2F targets under negative control by DREAM complex Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Asthma ( 31619474)	Obesity-related traits ( 23251661)
Interacting Genes		40 interacting genes: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FAM13A-AS1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC OGT ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PLK1 PPP2R3A PPP2R3B PSKH1 RPS27A SQSTM1 TERF1 UBC UBE2K UBR1	22 interacting genes: APP CCNE2 CDC45 CDC6 CDK4 CEBPA DBF4 FBXO7 H3-4 H4C16 MCM10 MCM4 MCM5 MCM7 ORC1 ORC2 ORC4 ORC5 ORC6 SUMO2 TERF2 USP2
Entrez ID		990	23595
HPRD ID		04022	05398
Ensembl ID		ENSG00000094804	ENSG00000135336
Uniprot IDs		Q99741	Q9UBD5
PDB IDs		2CCH 2CCI 4I5L 4I5N 8HT7 8RWV 8S0E	5UJ8 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication Regulation Of DNA Replication Nucleoplasm DNA Metabolic Process DNA Replication Origin Binding Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Chromosome, Telomeric Region Regulation Of Cell Cycle Process Origin Recognition Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Nucleic Acid Metabolic Process Regulation Of DNA-templated DNA Replication Initiation Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Cell Cycle G1/S Phase Transition Cell Division Regulation Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cellular Response To Stress Negative Regulation Of Cell Cycle Process DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Cell Cycle G2/M Phase Transition Protein Modification Process Positive Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Regulation Of Primary Metabolic Process Chromosome Positive Regulation Of DNA Replication Regulation Of DNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Fibroblast Proliferation Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Nucleolus	DNA Replication Initiation DNA Replication Origin Binding DNA Replication Chromosome, Telomeric Region DNA Metabolic Process Origin Recognition Complex Nuclear Origin Of Replication Recognition Complex Nucleoplasm Nucleus CMG Complex Nucleic Acid Metabolic Process Double-strand Break Repair Via Break-induced Replication Regulation Of DNA Replication Regulation Of Cell Cycle Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Single-stranded DNA Binding MCM Complex Positive Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of DNA-templated DNA Replication Initiation Chromosome Single-stranded DNA Helicase Activity DNA Replication Checkpoint Signaling Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Process DNA Binding Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Mitotic Cell Cycle Phase Transition Protein Heterodimerization Activity Mitotic DNA Replication Checkpoint Signaling DNA Strand Elongation Involved In DNA Replication Regulation Of Nucleobase-containing Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition ATP Binding DNA Recombination Positive Regulation Of Mitotic Cell Cycle Phase Transition DNA Strand Elongation Chromatin Binding Positive Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Damage Response
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