HOOK2 and ZC3H14

Number of citations of the paper that reports this interaction (PubMedID 19273536)
57

Data Source:
BioGRID (pull down)

		HOOK2	ZC3H14
Description		hook microtubule tethering protein 2	zinc finger CCCH-type containing 14
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Cytoskeleton Microtubule HOPS Complex FHF Complex	Nucleus Nucleolus Cytoplasm Nuclear Speck Dendrite Cytoplasm Axon Cytoplasm Ribonucleoprotein Complex
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding	RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Zinc Ion Binding Pre-mRNA Binding Metal Ion Binding
	Biological Process	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Protein Localization To Perinuclear Region Of Cytoplasm	Spermatogenesis Cell Differentiation Regulation Of MRNA Stability MRNA Stabilization Spliceosome-depend Formation Of Circular RNA
Pathways
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Platelet distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Visceral fat ( 30942860)
Interacting Genes		127 interacting genes: ABLIM1 AIRIM AKTIP ANKRD11 ANKRD36BP1 AP1M1 AP2M1 AP4M1 APEX2 ATG5 BYSL CABP2 CBX8 CCDC187 CCDC198 CCDC33 CCHCR1 CDK18 CDKN1A CEP95 CWF19L2 CYTH4 DCX DDX6 DUSP13B EIF3D ENKD1 EPS8 FAM107A FAM110A FAM161A FAM161B FAM50B FAM90A1 FGF16 FHIP1B FLYWCH1 GAS2L2 GEM GPKOW HAUS1 HDAC4 HOOK1 HOOK3 HOXB5 IL16 IPP IQCE ITSN2 KANSL1 KAT7 KIAA0408 KIF9 KLK15 KRT1 LENG1 LNX1 LRGUK MCM10 MCRS1 MFAP1 MORN3 MPPED2 MYLIP NEK6 OAS1 PARP11 PIMREG PKP1 PKP2 PPP1R18 PPP1R26 PRPF18 PRPF31 PRR35 PSMA1 PSMF1 RABGEF1 RALBP1 RBM41 RCOR3 RGS8 RIBC2 RITA1 RNF169 RNF6 SCNM1 SH2D4A SMARCB1 SNW1 SPATC1L SUV39H1 SYT17 SYT6 TBC1D22B TBC1D30 TCEA2 TCEANC TCHP TPM3 TSC1 TSGA10 TSGA10IP TTC23 USP2 UTP14A UTP14C VPS16 VPS41 ZBTB47 ZC2HC1C ZC3H14 ZFP1 ZFYVE26 ZGPAT ZNF107 ZNF250 ZNF35 ZNF417 ZNF48 ZNF497 ZNF572 ZNF587 ZNF638 ZNF648 ZNF835 ZNF844	9 interacting genes: DDIT3 DYNLT3 EXOC7 HOOK2 ITCH KRT20 KRT27 NEDD4 UBC
Entrez ID		29911	79882
HPRD ID		09698	13348
Ensembl ID		ENSG00000095066	ENSG00000100722
Uniprot IDs		Q96ED9	G3V256 Q6PJT7
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding FHF Complex HOPS Complex Protein Localization To Perinuclear Region Of Cytoplasm Centrosome Zinc Ion Binding Cytoskeleton Endosome To Lysosome Transport Spindle Pole Early Endosome To Late Endosome Transport Nucleus Lysosomal Transport Vacuole Organization Clathrin Adaptor Complex Lysosome Organization Microtubule Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Vacuolar Transport RNA Splicing	Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Negative Regulation Of Determination Of Dorsal Identity Modification-dependent Protein Catabolic Process Cytoplasm Proteolysis Involved In Protein Catabolic Process CHOP-ATF4 Complex CHOP-ATF3 Complex Regulation Of Autophagy Cytosol Receptor Internalization Channel Inhibitor Activity Protein K63-linked Ubiquitination Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization ATF6-mediated Unfolded Protein Response Macromolecule Catabolic Process GDF15-GFRAL Signaling Pathway HRI-mediated Signaling Involuntary Skeletal Muscle Contraction Blood Vessel Maturation CHOP-C/EBP Complex Establishment Of Protein Localization Negative Regulation Of Interleukin-4 Production Response To Nitrosative Stress Diaphragm Contraction Smooth Muscle Cell Proliferation Cellular Response To Nitrosative Stress Ubiquitin-dependent Protein Catabolic Process Vascular Associated Smooth Muscle Cell Proliferation Proteolysis Vascular Associated Smooth Muscle Cell Migration Sodium Channel Inhibitor Activity Cell Cortex Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Import Into Cell Vesicle-mediated Transport Endocytosis Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Vacuolar Transport Lysosomal Transport Beta-2 Adrenergic Receptor Binding Phosphothreonine Residue Binding Receptor-mediated Endocytosis Protein Ubiquitination
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