HOOK2 and PPP1R18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOOK2	PPP1R18
Description		hook microtubule tethering protein 2	protein phosphatase 1 regulatory subunit 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Cytoskeleton Microtubule HOPS Complex FHF Complex	Cytoplasm Cytoskeleton
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding	Actin Binding Protein Binding Phosphatase Binding
	Biological Process	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Protein Localization To Perinuclear Region Of Cytoplasm
Pathways
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Platelet distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Hemoglobin levels ( 32327693) Lung cancer ( 28604730)
Interacting Genes		127 interacting genes: ABLIM1 AIRIM AKTIP ANKRD11 ANKRD36BP1 AP1M1 AP2M1 AP4M1 APEX2 ATG5 BYSL CABP2 CBX8 CCDC187 CCDC198 CCDC33 CCHCR1 CDK18 CDKN1A CEP95 CWF19L2 CYTH4 DCX DDX6 DUSP13B EIF3D ENKD1 EPS8 FAM107A FAM110A FAM161A FAM161B FAM50B FAM90A1 FGF16 FHIP1B FLYWCH1 GAS2L2 GEM GPKOW HAUS1 HDAC4 HOOK1 HOOK3 HOXB5 IL16 IPP IQCE ITSN2 KANSL1 KAT7 KIAA0408 KIF9 KLK15 KRT1 LENG1 LNX1 LRGUK MCM10 MCRS1 MFAP1 MORN3 MPPED2 MYLIP NEK6 OAS1 PARP11 PIMREG PKP1 PKP2 PPP1R18 PPP1R26 PRPF18 PRPF31 PRR35 PSMA1 PSMF1 RABGEF1 RALBP1 RBM41 RCOR3 RGS8 RIBC2 RITA1 RNF169 RNF6 SCNM1 SH2D4A SMARCB1 SNW1 SPATC1L SUV39H1 SYT17 SYT6 TBC1D22B TBC1D30 TCEA2 TCEANC TCHP TPM3 TSC1 TSGA10 TSGA10IP TTC23 USP2 UTP14A UTP14C VPS16 VPS41 ZBTB47 ZC2HC1C ZC3H14 ZFP1 ZFYVE26 ZGPAT ZNF107 ZNF250 ZNF35 ZNF417 ZNF48 ZNF497 ZNF572 ZNF587 ZNF638 ZNF648 ZNF835 ZNF844	80 interacting genes: ABRA ACTN3 BICD2 CALCOCO2 CARD9 CBY2 CCDC102B CCDC136 CCDC57 CCDC88B CDR2L CEP70 COG6 DES DZIP1 EIF3L FAM9B FHL5 FSD2 GCC1 GFAP GMCL1 GOLGA2 GOLGA6L9 GOPC GRIPAP1 GTPBP3 HAP1 HOMER3 HOOK2 HSF2BP IKZF3 KASH5 KCTD9 KRT13 KRT15 KRT16 KRT19 KRT27 KRT31 KRT33B KRT34 KRT36 KRT40 LDOC1 LZTS1 LZTS2 MAD1L1 MAPK1 MEOX2 MID2 MRPL38 MTUS2 NACA NEFL PDE4DIP PIBF1 PLEKHF2 PPP1CA PPP1CC PPP1R13B PRPH SORBS3 SPDL1 STX11 TCF4 TEX11 TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TRIM62 TRIM69 TSC1 TSGA10 VIM VPS52 ZMYND12 ZRANB1
Entrez ID		29911	170954
HPRD ID		09698	11172
Ensembl ID		ENSG00000095066	ENSG00000146112
Uniprot IDs		Q96ED9	A0A024RCJ8 A0A0G2JHC2 Q6NYC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding FHF Complex HOPS Complex Protein Localization To Perinuclear Region Of Cytoplasm Centrosome Zinc Ion Binding Cytoskeleton Endosome To Lysosome Transport Spindle Pole Early Endosome To Late Endosome Transport Nucleus Lysosomal Transport Vacuole Organization Clathrin Adaptor Complex Lysosome Organization Microtubule Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Vacuolar Transport RNA Splicing	Cytoskeleton Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Intermediate Filament Organelle Organization Supramolecular Fiber Organization Structural Constituent Of Skin Epidermis Keratin Filament Structural Constituent Of Cytoskeleton Structural Molecule Activity Protein Binding Identical Protein Binding Intermediate Filament Cytoskeleton Microtubule-based Process Centrosome Morphogenesis Of An Epithelium Microtubule Cytoskeleton Organization Tissue Morphogenesis Cytosol Cytoplasm Microtubule Organizing Center Bergmann Glial Cell Differentiation Epithelial Cell Differentiation Microtubule Organizing Center Organization Negative Regulation Of Viral Transcription Intracellular Transport Developmental Process Regulation Of Viral Transcription Response To Muramyl Dipeptide Cellular Developmental Process Positive Regulation Of Skeletal Muscle Tissue Growth Establishment Of Localization In Cell Developmental Process Involved In Reproduction Establishment Of Protein Localization Dynein Light Intermediate Chain Binding Cytoskeleton-dependent Intracellular Transport Kinetochore Binding Regulation Of Autophagy Cell Differentiation Regulation Of Skeletal Muscle Tissue Growth Z Disc Intracellular Protein Localization Protein Transport Astrocyte Differentiation PTW/PP1 Phosphatase Complex Cellular Localization Organelle Transport Along Microtubule Cellular Response To Muramyl Dipeptide
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