HOOK2 and RALBP1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HOOK2	RALBP1
Gene Name		hook microtubule-tethering protein 2	ralA binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Microtubule HOPS Complex FHF Complex	Cytosol Membrane
	Molecular Function	Protein Binding Identical Protein Binding	GTPase Activator Activity Protein Binding ATPase Activity Ral GTPase Binding Rac GTPase Activator Activity ATPase Activity, Coupled To Movement Of Substances Rac GTPase Binding
	Biological Process	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Early Endosome To Late Endosome Transport	Transport Chemotaxis Signal Transduction Small GTPase Mediated Signal Transduction Metabolic Process Positive Regulation Of Rac GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Cdc42 GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways			Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: ABLIM1 AKTIP ANKRD11 ANKRD36BP1 AP1M1 APEX2 CCDC33 CWF19L2 DUSP13 EPS8 FAM107A HOOK1 HOOK3 IQCE ITSN2 KANSL1 KAT7 KIAA0408 MCM10 PSMF1 RALBP1 RIBC2 SUV39H1 USP2 UTP14A UTP14C VPS16 VPS41 ZC2HC1C ZNF250 ZNF638	27 interactors: AMOTL2 AP2M1 C1orf216 CASP8 CCNB1 CEP57 FADD GPS2 GSE1 HOOK2 HSF1 IKBKG PPL PRKCA RAC1 RALA RALB REPS1 REPS2 SMARCE1 SYNJ2BP TBRG1 TFPT TNIP1 TRAF2 ZBTB38 ZNF707
Entrez ID		29911	10928
HPRD ID		09698	09013
Ensembl ID		ENSG00000095066	ENSG00000017797
Uniprot IDs		Q96ED9	Q15311
PDB IDs			2KWH 2KWI
Enriched GO Terms of Interacting Partners?		Early Endosome To Late Endosome Transport Vacuolar Transport Endosomal Transport Vacuole Organization Endosome To Lysosome Transport Endosome Organization Lysosomal Transport Regulation Of SNARE Complex Assembly Lysosome Organization Cell Cycle Histone H4-K5 Acetylation Histone H4-K8 Acetylation Organelle Organization RRNA Processing RRNA Metabolic Process Maturation Of SSU-rRNA Cytoplasmic Transport Regulation Of Vesicle Fusion Ribosomal Small Subunit Biogenesis Ribosome Biogenesis Regulation Of Vacuole Fusion, Non-autophagic Vacuole Fusion, Non-autophagic Histone H4 Acetylation Peptidyl-lysine Modification Viral Process Protein Transport Actin Polymerization-dependent Cell Motility Vesicle-mediated Transport Establishment Of Protein Localization	Toll-like Receptor Signaling Pathway Positive Regulation Of Macrophage Differentiation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Innate Immune Response Programmed Cell Death Regulation Of Cellular Localization Immune Response-regulating Signaling Pathway Response To External Stimulus Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Localization Viral Process Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Apoptotic Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Response To Growth Factor Cellular Response To Stimulus Regulation Of Immune System Process Regulation Of Phosphorylation Positive Regulation Of Immune Response Signal Transduction Defense Response Cell Cycle Positive Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Protein Complex Assembly Response To Stress Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Myeloid Cell Differentiation
Tagcloud ?		accumulated approaches basic benign demonstrates encoding hmga hmga2 initiating leiomyoma leiomyomas limits mesenchymal mobility myometrial opens origin possibilities putative rearrangements side sp stem toward transformation truncated understand uterine work	abrogate complemented counteracts cytoplasmic downstream effectors equally gef hairpin kip1 lacks localization mislocalization mislocalizing murine note opposing overactivation p27 phospholipase pld1 rala ras ser thr transforming ways
Tagcloud (Difference) ?		accumulated approaches basic benign demonstrates encoding hmga hmga2 initiating leiomyoma leiomyomas limits mesenchymal mobility myometrial opens origin possibilities putative rearrangements side sp stem toward transformation truncated understand uterine work	abrogate complemented counteracts cytoplasmic downstream effectors equally gef hairpin kip1 lacks localization mislocalization mislocalizing murine note opposing overactivation p27 phospholipase pld1 rala ras ser thr transforming ways
Tagcloud (Intersection) ?