HOOK2 and RCOR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOOK2	RCOR3
Description		hook microtubule tethering protein 2	REST corepressor 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Cytoskeleton Microtubule HOPS Complex FHF Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytosol
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Protein Localization To Perinuclear Region Of Cytoplasm	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Platelet distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Plateletcrit ( 32888494)
Interacting Genes		127 interacting genes: ABLIM1 AIRIM AKTIP ANKRD11 ANKRD36BP1 AP1M1 AP2M1 AP4M1 APEX2 ATG5 BYSL CABP2 CBX8 CCDC187 CCDC198 CCDC33 CCHCR1 CDK18 CDKN1A CEP95 CWF19L2 CYTH4 DCX DDX6 DUSP13B EIF3D ENKD1 EPS8 FAM107A FAM110A FAM161A FAM161B FAM50B FAM90A1 FGF16 FHIP1B FLYWCH1 GAS2L2 GEM GPKOW HAUS1 HDAC4 HOOK1 HOOK3 HOXB5 IL16 IPP IQCE ITSN2 KANSL1 KAT7 KIAA0408 KIF9 KLK15 KRT1 LENG1 LNX1 LRGUK MCM10 MCRS1 MFAP1 MORN3 MPPED2 MYLIP NEK6 OAS1 PARP11 PIMREG PKP1 PKP2 PPP1R18 PPP1R26 PRPF18 PRPF31 PRR35 PSMA1 PSMF1 RABGEF1 RALBP1 RBM41 RCOR3 RGS8 RIBC2 RITA1 RNF169 RNF6 SCNM1 SH2D4A SMARCB1 SNW1 SPATC1L SUV39H1 SYT17 SYT6 TBC1D22B TBC1D30 TCEA2 TCEANC TCHP TPM3 TSC1 TSGA10 TSGA10IP TTC23 USP2 UTP14A UTP14C VPS16 VPS41 ZBTB47 ZC2HC1C ZC3H14 ZFP1 ZFYVE26 ZGPAT ZNF107 ZNF250 ZNF35 ZNF417 ZNF48 ZNF497 ZNF572 ZNF587 ZNF638 ZNF648 ZNF835 ZNF844	73 interacting genes: ABI1 ANKRD11 APP BORCS6 CBY2 CCDC102B CCDC106 CCHCR1 CDR2 CEP55 CEP63 CEP70 EFHC2 FAM81A FSD2 GKAP1 GLRX3 GOLGA2 GPRASP3 GRIPAP1 GSE1 HAUS3 HMBOX1 HOOK2 HSF2BP ICA1L IKZF3 ING5 ISY1-RAB43 KDM1A KRT15 KRT18 KRT19 KRT24 KRT27 KRT31 KRT40 KRT75 LCA5 LHX3 LUZP4 LZTS2 MAGEA6 MCC MESD MID2 MIPOL1 MTUS2 NDUFB7 NECAB2 NINL NRDE2 NUTM1 PHF19 PIH1D1 PRDM14 PTTG2 STN1 SUMO2 TFIP11 TRAF1 TRAF2 TRIM27 TRIM42 TRIM54 TSGA10 TULP3 TXLNA USHBP1 VAX1 YWHAQ ZNF383 ZNF688
Entrez ID		29911	55758
HPRD ID		09698	08338
Ensembl ID		ENSG00000095066	ENSG00000117625
Uniprot IDs		Q96ED9	Q9P2K3
PDB IDs			4CZZ
Enriched GO Terms of Interacting Partners?		Protein Binding FHF Complex HOPS Complex Protein Localization To Perinuclear Region Of Cytoplasm Centrosome Zinc Ion Binding Cytoskeleton Endosome To Lysosome Transport Spindle Pole Early Endosome To Late Endosome Transport Nucleus Lysosomal Transport Vacuole Organization Clathrin Adaptor Complex Lysosome Organization Microtubule Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Vacuolar Transport RNA Splicing	Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoskeleton Intermediate Filament Organization Intermediate Filament Structural Molecule Activity Protein Binding Identical Protein Binding Supramolecular Fiber Organization Microtubule TORC1 Complex Assembly Cytoskeleton Organization Epithelial Cell Differentiation Microtubule-based Process Telomeric DNA Binding Centrosome
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