HOOK2 and FAM50B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOOK2	FAM50B
Description		hook microtubule tethering protein 2	family with sequence similarity 50 member B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Cytoskeleton Microtubule HOPS Complex FHF Complex	Nucleus Nucleoplasm Midbody Intercellular Bridge
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding	Protein Binding
	Biological Process	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Protein Localization To Perinuclear Region Of Cytoplasm	Chromatin Organization
Pathways
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Platelet distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) ( 23648065)
Interacting Genes		127 interacting genes: ABLIM1 AIRIM AKTIP ANKRD11 ANKRD36BP1 AP1M1 AP2M1 AP4M1 APEX2 ATG5 BYSL CABP2 CBX8 CCDC187 CCDC198 CCDC33 CCHCR1 CDK18 CDKN1A CEP95 CWF19L2 CYTH4 DCX DDX6 DUSP13B EIF3D ENKD1 EPS8 FAM107A FAM110A FAM161A FAM161B FAM50B FAM90A1 FGF16 FHIP1B FLYWCH1 GAS2L2 GEM GPKOW HAUS1 HDAC4 HOOK1 HOOK3 HOXB5 IL16 IPP IQCE ITSN2 KANSL1 KAT7 KIAA0408 KIF9 KLK15 KRT1 LENG1 LNX1 LRGUK MCM10 MCRS1 MFAP1 MORN3 MPPED2 MYLIP NEK6 OAS1 PARP11 PIMREG PKP1 PKP2 PPP1R18 PPP1R26 PRPF18 PRPF31 PRR35 PSMA1 PSMF1 RABGEF1 RALBP1 RBM41 RCOR3 RGS8 RIBC2 RITA1 RNF169 RNF6 SCNM1 SH2D4A SMARCB1 SNW1 SPATC1L SUV39H1 SYT17 SYT6 TBC1D22B TBC1D30 TCEA2 TCEANC TCHP TPM3 TSC1 TSGA10 TSGA10IP TTC23 USP2 UTP14A UTP14C VPS16 VPS41 ZBTB47 ZC2HC1C ZC3H14 ZFP1 ZFYVE26 ZGPAT ZNF107 ZNF250 ZNF35 ZNF417 ZNF48 ZNF497 ZNF572 ZNF587 ZNF638 ZNF648 ZNF835 ZNF844	49 interacting genes: ACTN2 ADRA1A BICD2 CARD9 CCDC136 CCDC57 CCDC85B CCDC89 CCNC CDR2 DEUP1 FSD2 GFAP GMCL1 GOLGA2 GRIPAP1 HAP1 HOOK2 IKZF1 KASH5 KPNA3 KPNA4 KRT31 KRT34 LDOC1 LZTS1 LZTS2 MID1 MID2 MLH1 NUTF2 PAX6 PDE4DIP PIBF1 PSMB1 RABEP1 TACC1 TBC1D1 TFIP11 TRAF2 TRIM14 TRIM37 TRIM54 UBL5 VAC14 VPS52 WBP4 ZMYND12 ZRANB1
Entrez ID		29911	26240
HPRD ID		09698	16883
Ensembl ID		ENSG00000095066	ENSG00000145945
Uniprot IDs		Q96ED9	Q9Y247
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding FHF Complex HOPS Complex Protein Localization To Perinuclear Region Of Cytoplasm Centrosome Zinc Ion Binding Cytoskeleton Endosome To Lysosome Transport Spindle Pole Early Endosome To Late Endosome Transport Nucleus Lysosomal Transport Vacuole Organization Clathrin Adaptor Complex Lysosome Organization Microtubule Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Vacuolar Transport RNA Splicing	Microtubule-based Process Cytoskeleton Organization Microtubule Cytoskeleton Organization Cytoskeleton Organelle Organization Cytoplasm Intracellular Protein Localization Protein Binding Protein Localization To Organelle Identical Protein Binding Nuclear Import Signal Receptor Activity Protein Transport Cellular Localization Intracellular Transport Spindle Organization Microtubule Organizing Center Organization Nuclear Pore Regulation Of Microtubule-based Process Centrosome Establishment Of Protein Localization Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Establishment Of Localization In Cell Telomere Localization Organelle Localization NLS-dependent Protein Nuclear Import Complex Protein Localization To Cytoskeleton Microtubule Microtubule Cytoskeleton Organization Involved In Mitosis Ubiquitin Protein Ligase Activity Spindle Midzone Assembly Cellular Component Assembly Protein Localization To Microtubule Microtubule Binding Positive Regulation Of Synaptic Transmission, GABAergic Enzyme Binding Negative Regulation Of Viral Transcription Membraneless Organelle Assembly Intermediate Filament Organization Regulation Of Microtubule Cytoskeleton Organization Transcription Coactivator Activity Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Endocytic Recycling Regulation Of Viral Transcription Chromosome Localization Dynein Complex Binding Response To Muramyl Dipeptide
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