HOOK2 and PPP1R26

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOOK2	PPP1R26
Description		hook microtubule tethering protein 2	protein phosphatase 1 regulatory subunit 26
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Cytoskeleton Microtubule HOPS Complex FHF Complex	Nucleus Nucleolus
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding	Protein Phosphatase Inhibitor Activity Protein Binding
	Biological Process	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Protein Localization To Perinuclear Region Of Cytoplasm
Pathways
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Platelet distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		127 interacting genes: ABLIM1 AIRIM AKTIP ANKRD11 ANKRD36BP1 AP1M1 AP2M1 AP4M1 APEX2 ATG5 BYSL CABP2 CBX8 CCDC187 CCDC198 CCDC33 CCHCR1 CDK18 CDKN1A CEP95 CWF19L2 CYTH4 DCX DDX6 DUSP13B EIF3D ENKD1 EPS8 FAM107A FAM110A FAM161A FAM161B FAM50B FAM90A1 FGF16 FHIP1B FLYWCH1 GAS2L2 GEM GPKOW HAUS1 HDAC4 HOOK1 HOOK3 HOXB5 IL16 IPP IQCE ITSN2 KANSL1 KAT7 KIAA0408 KIF9 KLK15 KRT1 LENG1 LNX1 LRGUK MCM10 MCRS1 MFAP1 MORN3 MPPED2 MYLIP NEK6 OAS1 PARP11 PIMREG PKP1 PKP2 PPP1R18 PPP1R26 PRPF18 PRPF31 PRR35 PSMA1 PSMF1 RABGEF1 RALBP1 RBM41 RCOR3 RGS8 RIBC2 RITA1 RNF169 RNF6 SCNM1 SH2D4A SMARCB1 SNW1 SPATC1L SUV39H1 SYT17 SYT6 TBC1D22B TBC1D30 TCEA2 TCEANC TCHP TPM3 TSC1 TSGA10 TSGA10IP TTC23 USP2 UTP14A UTP14C VPS16 VPS41 ZBTB47 ZC2HC1C ZC3H14 ZFP1 ZFYVE26 ZGPAT ZNF107 ZNF250 ZNF35 ZNF417 ZNF48 ZNF497 ZNF572 ZNF587 ZNF638 ZNF648 ZNF835 ZNF844	5 interacting genes: HOOK2 PPP1CA RB1 TRIB3 UTP20
Entrez ID		29911	9858
HPRD ID		09698	11099
Ensembl ID		ENSG00000095066	ENSG00000196422
Uniprot IDs		Q96ED9	Q5T8A7
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding FHF Complex HOPS Complex Protein Localization To Perinuclear Region Of Cytoplasm Centrosome Zinc Ion Binding Cytoskeleton Endosome To Lysosome Transport Spindle Pole Early Endosome To Late Endosome Transport Nucleus Lysosomal Transport Vacuole Organization Clathrin Adaptor Complex Lysosome Organization Microtubule Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Vacuolar Transport RNA Splicing	RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex Double-strand Break Repair Via Alternative Nonhomologous End Joining RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Transcription By RNA Polymerase II Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Transcription Corepressor Activity Ubiquitin Protein Ligase Binding Negative Regulation Of Myofibroblast Differentiation Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Regulation Of Myofibroblast Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Enucleate Erythrocyte Differentiation Cellular Response To Insulin Stimulus Glial Cell Apoptotic Process Response To Insulin Rb-E2F Complex Regulation Of Protein Kinase Activity Regulation Of Centromere Complex Assembly Cellular Response To Peptide Hormone Stimulus Regulation Of Collagen Fibril Organization Cyclin/CDK Positive Transcription Elongation Factor Complex Regulation Of Kinase Activity Response To Peptide Hormone Chromatin Lock Complex Importin-alpha Family Protein Binding Positive Regulation Of Collagen Fibril Organization Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage To Generate Mature 5'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) 90S Preribosome Protein Localization To Perinuclear Region Of Cytoplasm FHF Complex Mitogen-activated Protein Kinase Kinase Binding Ubiquitin-protein Transferase Regulator Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Small Molecule Metabolic Process Preribosome, Small Subunit Precursor Ubiquitin Ligase Activator Activity Negative Regulation Of DNA-templated Transcription Chromosome Organization Negative Regulation Of RNA Biosynthetic Process
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