HOOK2 and MYLIP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOOK2	MYLIP
Description		hook microtubule tethering protein 2	myosin regulatory light chain interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Cytoskeleton Microtubule HOPS Complex FHF Complex	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Protein Localization To Perinuclear Region Of Cytoplasm	Ubiquitin-dependent Protein Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Positive Regulation Of Protein Catabolic Process
Pathways			VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Platelet distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Apolipoprotein B levels ( 32203549) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Cholesterol, total ( 24097068) Diisocyanate-induced asthma ( 25918132) Femoral neck bone mineral density ( 30172743) LDL cholesterol ( 20864672 24097068 25961943) LDL cholesterol levels ( 32203549 30698716 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Major depressive disorder ( 23377640) Medication use (HMG CoA reductase inhibitors) ( 31015401) Response to statins (LDL cholesterol change) ( 22331829) Total cholesterol levels ( 28334899)
Interacting Genes		127 interacting genes: ABLIM1 AIRIM AKTIP ANKRD11 ANKRD36BP1 AP1M1 AP2M1 AP4M1 APEX2 ATG5 BYSL CABP2 CBX8 CCDC187 CCDC198 CCDC33 CCHCR1 CDK18 CDKN1A CEP95 CWF19L2 CYTH4 DCX DDX6 DUSP13B EIF3D ENKD1 EPS8 FAM107A FAM110A FAM161A FAM161B FAM50B FAM90A1 FGF16 FHIP1B FLYWCH1 GAS2L2 GEM GPKOW HAUS1 HDAC4 HOOK1 HOOK3 HOXB5 IL16 IPP IQCE ITSN2 KANSL1 KAT7 KIAA0408 KIF9 KLK15 KRT1 LENG1 LNX1 LRGUK MCM10 MCRS1 MFAP1 MORN3 MPPED2 MYLIP NEK6 OAS1 PARP11 PIMREG PKP1 PKP2 PPP1R18 PPP1R26 PRPF18 PRPF31 PRR35 PSMA1 PSMF1 RABGEF1 RALBP1 RBM41 RCOR3 RGS8 RIBC2 RITA1 RNF169 RNF6 SCNM1 SH2D4A SMARCB1 SNW1 SPATC1L SUV39H1 SYT17 SYT6 TBC1D22B TBC1D30 TCEA2 TCEANC TCHP TPM3 TSC1 TSGA10 TSGA10IP TTC23 USP2 UTP14A UTP14C VPS16 VPS41 ZBTB47 ZC2HC1C ZC3H14 ZFP1 ZFYVE26 ZGPAT ZNF107 ZNF250 ZNF35 ZNF417 ZNF48 ZNF497 ZNF572 ZNF587 ZNF638 ZNF648 ZNF835 ZNF844	42 interacting genes: ADAMTSL4 AR ARID5A CNPY2 CRK DAPP1 DDIT4L EFHC2 EXOSC5 FAM217B GMCL1 HOOK2 INO80B KANK4 KDM1A LDLR LNX2 LRP8 MIPOL1 MTAP MYL12B NHLRC4 NOXA1 NR1D2 PAX9 RASSF5 SCNM1 SDCBP SRPK2 TCEANC TSC1 TSC22D4 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR ZBTB16 ZBTB18 ZBTB42 ZNF417 ZNF438
Entrez ID		29911	29116
HPRD ID		09698	17621
Ensembl ID		ENSG00000095066	ENSG00000007944
Uniprot IDs		Q96ED9	Q5TIA5 Q8WY64
PDB IDs			2YHN 2YHO 6QLY 6QLZ
Enriched GO Terms of Interacting Partners?		Protein Binding FHF Complex HOPS Complex Protein Localization To Perinuclear Region Of Cytoplasm Centrosome Zinc Ion Binding Cytoskeleton Endosome To Lysosome Transport Spindle Pole Early Endosome To Late Endosome Transport Nucleus Lysosomal Transport Vacuole Organization Clathrin Adaptor Complex Lysosome Organization Microtubule Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Vacuolar Transport RNA Splicing	Very-low-density Lipoprotein Particle Receptor Activity Ubiquitin Conjugating Enzyme Activity Reelin-mediated Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Low-density Lipoprotein Particle Receptor Activity Reelin Receptor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Protein Binding Cerebral Cortex Development Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Ventral Spinal Cord Development Negative Regulation Of Macromolecule Metabolic Process Nucleus Ubiquitin-protein Transferase Activity Protein-containing Complex Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Dendrite Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Hippocampus Development Cellular Response To Estrogen Stimulus Identical Protein Binding Apolipoprotein Binding Regulation Of Low-density Lipoprotein Particle Clearance
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