PSPC1 and WBP4

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		PSPC1	WBP4
Description		paraspeckle component 1	WW domain binding protein 4
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Matrix Nuclear Speck Paraspeckles	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Proline-rich Region Binding
	Biological Process	Activation Of Innate Immune Response Immune System Process Regulation Of DNA-templated Transcription Regulation Of Circadian Rhythm Innate Immune Response Negative Regulation Of DNA-templated Transcription Rhythmic Process Membraneless Organelle Assembly	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Waist circumference adjusted for body mass index ( 28552196)	Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)
Interacting Genes		16 interacting genes: CEBPA DANCR DISC1 ESR1 KRT31 KRTAP13-1 LRIF1 LZTS1 NEIL3 NONO NUDT21 SFPQ TCERG1 WBP4 ZRANB1 ZSCAN5B	66 interacting genes: ARGLU1 BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 CSDE1 DDX23 DDX3X DHX15 DHX38 DIAPH1 DMRTB1 DNM2 EFTUD2 EIF4ENIF1 EIF5B EWSR1 FAM50B FUS HLTF HNRNPK HNRNPU HTATSF1 ISY1 KHDRBS1 LARP4 NONO OGT PABPC1 PPIA PRPF3 PRPF4 PRPF40A PSPC1 RARS1 RBM22 RBM42 RBPMS SART1 SCAF4 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNRNP27 SNRNP70 SNRPA SNRPB SNW1 SQSTM1 TCERG1 TFIP11 TIA1 WAS WBP11 WDR83 WIPF1 XRCC6 ZC2HC1A ZNF207
Entrez ID		55269	11193
HPRD ID		10172	16086
Ensembl ID		ENSG00000121390	ENSG00000120688
Uniprot IDs		Q8WXF1	O75554
PDB IDs		3SDE 5IFN 5WPA	2DK1 2JXW 5O9Z 6AHD 7OS1 8H6K 8H6L 8Q7N 8QO9 8QPE 8QZS
Enriched GO Terms of Interacting Partners?		Paraspeckles Nuclear Matrix MRNA Processing Chromatin Binding Histone Deacetylase Binding RNA Metabolic Process RNA Polymerase II Transcription Regulator Complex Nucleic Acid Metabolic Process MRNA Metabolic Process RNA Splicing Nuclear Speck Nucleoplasm RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding RNA Processing Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Pro-B Cell Differentiation MCM Complex Binding Nucleobase-containing Compound Metabolic Process	MRNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Spliceosomal Complex RNA Processing RNA Metabolic Process Nucleic Acid Binding Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Nuclear Speck U2-type Precatalytic Spliceosome Macromolecule Metabolic Process U4/U6 X U5 Tri-snRNP Complex MRNA Binding U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Poly(A) Binding Protein-containing Complex Assembly Cellular Component Assembly Protein-containing Complex Organization Regulation Of MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of MRNA Processing Cytoplasmic Stress Granule MRNA 3'-splice Site Recognition MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Membraneless Organelle Assembly Paraspeckles Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Translation Pre-mRNA Binding Nuclear Matrix U1 SnRNP U1 SnRNP Binding Positive Regulation Of Translation Protein Binding
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