RIF1 and GIT1

Number of citations of the paper that reports this interaction (PubMedID 15383276)
0

Data Source:
HPRD (two hybrid)

		RIF1	GIT1
Description		replication timing regulatory factor 1	GIT ArfGAP 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Condensed Chromosome Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytoskeleton Plasma Membrane Nuclear Membrane Site Of Double-strand Break Spindle Midzone Chromosome, Telomeric Repeat Region	Spindle Pole Cytoplasm Mitochondrion Endosome Centrosome Cytosol Cytoskeleton Focal Adhesion Postsynaptic Density Membrane Lamellipodium Dendrite Growth Cone Cell Projection Neuron Projection Calyx Of Held Synapse Excitatory Synapse Inhibitory Synapse Anchoring Junction Mitotic Spindle Pole Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Protein Phosphatase Binding Small GTPase Binding Identical Protein Binding Gamma-tubulin Binding Protein-containing Complex Binding Metal Ion Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Specialization Protein Tyrosine Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Repair DNA Damage Response Subtelomeric Heterochromatin Formation Somatic Stem Cell Population Maintenance Telomere Maintenance In Response To DNA Damage Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Isotype Switching Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Immunological Synapse Formation Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Negative Regulation Of ARF Protein Signal Transduction Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Synaptic Vesicle Recycling Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Dendritic Spine Development Motor Learning Cellular Response To Lipopolysaccharide Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Microtubule Nucleation Maintenance Of Postsynaptic Specialization Structure Presynaptic Modulation Of Chemical Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Receptor Catabolic Process
Pathways		Nonhomologous End-Joining (NHEJ)	Ephrin signaling Ephrin signaling CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Activation of RAC1 downstream of NMDARs
Drugs
Diseases
GWAS		Lung cancer ( 23143601) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)	Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		20 interacting genes: BRD7 CEP126 CHD3 DEFB1 FEZ1 GIT1 GNE GRB2 HAP1 LINC00839 NSG2 PABPC4 PIAS4 POT1 PPP1CC SETDB1 SMARCD1 SUMO2 TERF2IP UBC	54 interacting genes: ARHGEF6 ARHGEF7 BARD1 C8orf33 CENPU CEP126 CFAP263 CHD3 DDX24 DSCR9 EIF6 ENTR1 GIT2 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HSPA13 HTT KIF1A KLHL4 LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG
Entrez ID		55183	28964
HPRD ID		10603	06577
Ensembl ID		ENSG00000080345	ENSG00000108262
Uniprot IDs		Q5UIP0	Q59FC3 Q9Y2X7
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Double-strand Break Repair Regulation Of DNA Repair Positive Regulation Of DNA Metabolic Process Shelterin Complex Regulation Of Microtubule-based Movement Regulation Of Organelle Organization Regulation Of Organelle Transport Along Microtubule Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Centrosome Telomere Capping Presynapse RSC-type Complex Protein Tag Activity Protein Phosphatase Binding Regulation Of Chromosome Organization Regulation Of Microtubule-based Process Positive Regulation Of Double-strand Break Repair Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization SUMO Transferase Activity PML Body Regulation Of Cellular Response To Stress Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Regulation Of Nucleotide-excision Repair Positive Regulation Of DNA Repair Nuclear Matrix Growth Cone Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Gamma-tubulin Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Chromosome Chromosome, Telomeric Region Kinetochore Regulation Of G0 To G1 Transition Positive Regulation Of Neurotrophin Production Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine 2-epimerase Activity Negative Regulation Of Telomere Maintenance Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of ARF Protein Signal Transduction Positive Regulation Of Myoblast Differentiation Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization	Beta-adrenergic Receptor Kinase Activity G Protein-coupled Receptor Kinase Activity Cytoplasm Presynaptic Active Zone Focal Adhesion Cell Projection Epidermal Growth Factor Receptor Signaling Pathway Signal Complex Assembly Cytoskeleton Cytosol ERBB Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Synapse Centrosome Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Organelle Localization Transforming Growth Factor Beta Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Kinase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Kinase Activity Vesicle Cytoskeletal Trafficking Positive Regulation Of Calcium Ion Transmembrane Transport Vesicle Localization Protein Autophosphorylation Centriolar Satellite ATP Binding Cell Junction Organization Desensitization Of G Protein-coupled Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-substrate Adhesion Protein-containing Complex Cellular Response To Fluid Shear Stress Synapse Organization Positive Regulation Of Cilium Assembly Negative Adaptation Of Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Establishment Of Organelle Localization Positive Regulation Of Organelle Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Phosphatase Binding Tachykinin Receptor Signaling Pathway Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Regulation Of Signaling Regulation Of Cell Projection Organization
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