RIF1 and PIAS4

Number of citations of the paper that reports this interaction (PubMedID 29234018)
52

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		RIF1	PIAS4
Description		replication timing regulatory factor 1	protein inhibitor of activated STAT 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Condensed Chromosome Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytoskeleton Plasma Membrane Nuclear Membrane Site Of Double-strand Break Spindle Midzone Chromosome, Telomeric Repeat Region	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body Transferase Complex
	Molecular Function	Protein Binding	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity SUMO Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Repair DNA Damage Response Subtelomeric Heterochromatin Formation Somatic Stem Cell Population Maintenance Telomere Maintenance In Response To DNA Damage Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Isotype Switching Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Negative Regulation Of Transcription By RNA Polymerase II Hair Follicle Development Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II DNA Damage Response Central Nervous System Development Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Sumoylation Positive Regulation Of Protein Sumoylation Vitamin D Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of MRNA Stability Negative Regulation Of DNA-templated Transcription Limb Epidermis Development MRNA Destabilization Regulation Of Cellular Response To Stress Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Nonhomologous End-Joining (NHEJ)	Vitamin D (calciferol) metabolism SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Lung cancer ( 23143601) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)	Chronic lymphocytic leukemia ( 28165464) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)
Interacting Genes		20 interacting genes: BRD7 CEP126 CHD3 DEFB1 FEZ1 GIT1 GNE GRB2 HAP1 LINC00839 NSG2 PABPC4 PIAS4 POT1 PPP1CC SETDB1 SMARCD1 SUMO2 TERF2IP UBC	91 interacting genes: ACTN1 ALDOA AR AREL1 BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G GATA1 HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KNTC1 KPNB1 KRT18 LAMP2 LCE1D LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRKCZ PRPF40A PTN RBBP8 RIF1 RPA2 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNAI2 SNIP1 STIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TOP1 TOP2A TP53 TRIM27 TRIM32 TRIM38 UBE2I UBE2K VHL VIM YY1 ZBTB34 ZHX1 ZNF512B ZW10
Entrez ID		55183	51588
HPRD ID		10603	06910
Ensembl ID		ENSG00000080345	ENSG00000105229
Uniprot IDs		Q5UIP0	B3KMR4 Q8N2W9
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Double-strand Break Repair Regulation Of DNA Repair Positive Regulation Of DNA Metabolic Process Shelterin Complex Regulation Of Microtubule-based Movement Regulation Of Organelle Organization Regulation Of Organelle Transport Along Microtubule Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Centrosome Telomere Capping Presynapse RSC-type Complex Protein Tag Activity Protein Phosphatase Binding Regulation Of Chromosome Organization Regulation Of Microtubule-based Process Positive Regulation Of Double-strand Break Repair Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization SUMO Transferase Activity PML Body Regulation Of Cellular Response To Stress Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Regulation Of Nucleotide-excision Repair Positive Regulation Of DNA Repair Nuclear Matrix Growth Cone Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Gamma-tubulin Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Chromosome Chromosome, Telomeric Region Kinetochore Regulation Of G0 To G1 Transition Positive Regulation Of Neurotrophin Production Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine 2-epimerase Activity Negative Regulation Of Telomere Maintenance Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of ARF Protein Signal Transduction Positive Regulation Of Myoblast Differentiation Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromatin Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process SMAD Protein Signal Transduction Chromatin Binding Positive Regulation Of Cell Differentiation DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Heteromeric SMAD Protein Complex Positive Regulation Of Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Ubiquitin Protein Ligase Binding Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Developmental Process
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